Clinical trials: completed, sponsored by UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Metastasis
Assessing Functional Status Needs Via PRO Measures for Pts With Metastatic Breast Cancer
The purpose of this single-site non-randomized study is to identify areas of need related to functional status and overall health, including nutrition and mental health in subjects with metastatic breast cancer (MBC).
- Trial name
- NCT05755347
- Testing
- General health survey questionnaires, PROMIS Cancer Function Brief 3D profile questionnaires, FACT-G questionnaires
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Colon Cancer
Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy
The study will look at conducting a medium-intense walking program called Walk With Ease with cancer patients age 60 and above who are starting chemotherapy treatment.
- Conditions
- Breast Cancer, Colon Cancer, Lung Cancer
- Trial name
- WWE (NCT01789983)
- Testing
- Walk With Ease Program, Collect Blood, GA and Other Survey Tools
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Melanoma
An Exploratory Study of Pembrolizumab Plus Entinostat in Non-Inflamed Stage III/IV Melanoma
Cancers develop in two different ways. First, cancer cells can become invisible to the immune system by stop having proteins on their surface that are required for the immune system to recognize them.
- Trial name
- NCT03765229
- Testing
- Entinostat, Pembrolizumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Thoracic Surgery
Pre-Implementation Study of Improving Thoracic Surgical Care Using Electronic Patient-Reported Outcomes (ePROS)
The purpose of the LCCC 2202 is to evaluate the barriers and facilitators to implementing perioperative "ePRO monitoring". This study will inform a future hybrid effectiveness study (LCCC 2141:Improving Thoracic Surgical Care…
- Trial name
- TSPRO2 (NCT05311670)
- Testing
- Patient-reported outcomes monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Advanced Colorectal Cancer
Effect of Curcumin on Dose Limiting Toxicity and Pharmacokinetics of Irinotecan in Patients With Solid Tumors
Curcumin is an extract of the tumeric root that has been shown to have anti-tumor properties in laboratory studies. Curcumin, and its parent spice, turmeric (curcuma longa), are the 4th most commonly purchased dietary supplement…
- Trial name
- NCT01859858
- Testing
- curcumin, Irinotecan
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Metastatic Breast Cancer
Study of BKM120 or BYL719 and Capecitabine in Patients With Metastatic Breast Cancer
This phase I study has been designed to establish the safety, tolerability and maximum tolerated dose (MTD) of four separate regimens for patients with metastatic breast cancer: dose- escalating BKM120 when combined with…
- Trial name
- NCT01300962
- Testing
- BMK120, Capecitabine, BYL719
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Melanoma
Pembrolizumab TX-naive Distant Mets Melanoma and Use of (C11-AMT) PET at Baseline as Imaging Biomarker
Explore the association between intensity of 11C-methyl-L-tryptophan (C11-AMT) positron emission tomography (PET) at baseline, as measured by mean standardized uptake value (SUVmax) at each lesion, total tumor metabolic volume…
- Trial name
- NCT03089606
- Testing
- FDG PET/CT scan, C11-AMT PET scan, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Kidney Cancer
Contrast-Enhanced Ultrasound for Kidney Cancer Subtyping and Staging
The purpose of this study is to determine if contrast-enhanced ultrasound can detect abnormal features of kidney lesions in patients with suspected kidney cancer with the same accuracy as conventional ultrasound and…
- Trial name
- NCT04021238
- Testing
- Perflutren lipid microsphere, Sulfur hexafluoride lipid microspheres
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute GVHD
Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplant (HCT)
The purpose of this research study is to evaluate tacrolimus plasma concentrations in patients who will undergo an allogeneic hematopoietic stem cell transplant (HCT).
- Trial name
- NCT04645667
- Testing
- Tacrolimus
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lung Cancer, Neoplasms, Lung
Remote Monitoring of Lung Cancer Patient-Reported Outcomes Using Moovcare®
The purpose of this study is to demonstrate how Moovcare®, a mobile medical application, can be used to monitor Patient-Reported Outcomes (PROs) related to cancer treatment, cancer complications, and cancer relapse in patients…
- Conditions
- Lung Cancer, Neoplasms, Lung, Neoplasms, Pulmonary, Pulmonary Cancer
- Trial name
- LC-PRO (NCT05011890)
- Testing
- Moovcare® use
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer, Physical Activity
mHealth Physical Activity Intervention for Survivors of Adolescent and Young Adult Cancers
The purpose of this study is to examine the feasibility, acceptability, and gather preliminary data on outcomes of a 3-month mHealth intervention to promote physical activity among adolescent and young adult (AYA) cancer…
- Trial name
- THRIVE (NCT03386383)
- Testing
- Intervention
- Where
- 3 sites in United States
- Volunteers
- 64 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Head and Neck Cancer, Oropharynx Cancer
Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx
The proposed study is an attempt to improve patient xerostomia (dry mouth) after definitive radiation therapy treatment for head and neck cancer.
- Conditions
- Head and Neck Cancer, Oropharynx Cancer, Xerostomia Due to Radiotherapy
- Trial name
- NCT03418792
- Testing
- Parotid-Sparing Head & Neck Radiation Guided by MRI Sialography
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Triple Negative Breast Cancer
Study Of Single-dose Cyclophosphamide +Pembrolizumab In Patients With Metastatic Triple Negative Breast Cancer
The purpose of this study is to evaluate pembrolizumab therapy in patients with triple-negative breast cancer (TNBC) who have received at least one prior line of therapy.
- Trial name
- NCT02768701
- Testing
- Pembrolizumab, Cyclophosphamide
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Screening
Novel MRI Sequence MR Fingerprinting in Breast MRI Feasibility Study
The purpose of this study is to evaluate potential clinical efficacy of a novel magnetic resonance imaging (MRI) approach, MR fingerprinting, capable of providing quantitative measures of important tissue properties, which could…
- Trial name
- NCT03846947
- Testing
- MR Fingerprinting
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Chemotherapy-induced Nausea and Vomiting
Olanzapine for Nausea/Vomiting Prophylaxis in Recipients of Hematopoietic Stem Cell Transplants
The purpose of this research study is to see if olanzapine helps to prevent nausea and/or vomiting (throwing up) when it is added to other medicines in subjects having stem cell transplants.
- Trial name
- NCT04535141
- Testing
- Olanzapine 5 MG
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Myeloid Leukemia
Chemotherapy-related Cognitive Impairment and Acute Leukemia
This is an ancillary study of an intervention study (NCT04570709). The parent study is a single institution, feasibility trial of 20 (10 control and 10 intervention) patients with the primary objective of assessing feasibility…
- Trial name
- NCT04644419
- Testing
- none (observational study)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cognitive Decline, Chemo-brain
Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer
Purpose: To conduct a one-arm phase II trial to: (1) compare changes in pre- to post-chemotherapy cognitive function in a cohort of patients with breast cancer receiving memantine to historical controls; (2) examine how…
- Trial name
- NCT04033419
- Testing
- Memantine
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
CML, Chronic Phase, CML (Chronic Myelogenous Leukemia
Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients
The purpose of this prospective, single-institution observational study is to evaluate associations between the pharmacokinetic (PK) parameters for tyrosine kinase inhibitors (TKIs) used to treat chronic phase chronic myeloid…
- Conditions
- CML, Chronic Phase, CML (Chronic Myelogenous Leukemia, CML - Philadelphia Chromosome, Chronic Myeloid Leukemia
- Trial name
- NCT03885830
- Testing
- Bosutinib, Dasatinib, Imatinib
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Esophageal Squamous Cell Carcinoma
HIV and Other Risk Factors for Esophageal Squamous Cell Carcinoma in Malawi
The primary purpose of this single-center, case-control, non-interventional study is to determine risk factors which contribute to the development of esophageal squamous cell carcinoma (ESCC) at Kamuzu Central Hospital (KCH) and…
- Trial name
- NCT03160209
- Where
- 2 sites in Malawi
- Volunteers
- 600 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Selective Image Guided Resection of Pathologically Documented Axillary Lymph Node Metastases
The purpose of this research study is to determine how feasible and accurate identifying and removing specific lymph nodes in the axilla (armpit) after neoadjuvant systemic therapy is when patients present with breast cancer that…
- Trial name
- TAD (NCT03281720)
- Testing
- TAD
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center