Clinical trials: sponsored by Umeå University
PONV, Postoperative Pain
Pain and Nausea After Gallbladder Surgery
The study is primarily an exploratory study of quality registry data for a swedish national cohort of patients who have undergone gallbladder surgery or ERCP, with the aim of investigating the occurrence of pain and PONV…
- Conditions
- PONV, Postoperative Pain, Postoperative Complications, Gall Bladder Disease
- Trial name
- NCT06083558
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Umeå University
Keratoconus, Corneal Crosslinking
Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus
The purpose of this study is to evaluate the efficacy, safety and postoperative ocular discomfort by comparing individually customized Photorefractive intrastromal crosslinking (PiXL) for progressive Keratoconus.
- Conditions
- Keratoconus, Corneal Crosslinking, Corneal Biomechanics, Corneal Densitometry
- Trial name
- NCT03990506
- Testing
- Epi-on PiXL, Epi-Off PiXL
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Postoperative Complications
Goal-directed Low Oxygen During Anesthesia
The study aims at investigate whether low oxygen therapy during anesthesia improves oxygen partial pressure and lung function in the postoperative period after abdominal surgery.
- Trial name
- NCT05263154
- Testing
- Goal directed low oxygen, High oxygen
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Glaucoma
The Glaucoma Nicotinamide Trial
The Glaucoma Nicotinamide Trial (TGNT) is a prospective, randomized, placebo-controlled double-masked clinical trial composed of two cohorts; The Swedish Glaucoma Nicotinamide Trial (SGNT) and the Vitamin B3 In Glaucoma Study…
- Trial name
- TGNT (NCT05275738)
- Testing
- Nicotinamide
- Where
- 2 sites in Sweden
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Umeå University
Glaucoma
Nicotinamide and Glaucoma
The investigators will include different subgroups of open-angle glaucoma and healthy controls. The participants will attend two visits with two weeks apart.
- Trial name
- NCT05916066
- Testing
- Nicotinamide
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Umeå University
Acute Kidney Injury, Osmolality Disturbance
Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Conditions
- Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass
- Trial name
- NCT05914896
- Testing
- HighOsmo
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
COPD, Healthy Older Adults
Acute Effects of Supramaximal High-Intensity Interval Training in People With COPD
High-intensity exercise is essential for optimal development of cardiorespiratory fitness and health. This is, however, challenging for most people with chronic obstructive pulmonary disease (COPD) due to ventilatory limitations…
- Trial name
- COPD-HIIT-AC (NCT05874999)
- Testing
- Supramaximal High-Intensity Interval Training at 60% of MPO6, Moderate-Intensity Continuous Training, Supramaximal High-Intensity Interval Training at 80% of MPO6
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Umeå University
Cleft Lip and Palate
How Does Orthognathic Surgery Affect Jaw and Neck Motor Function?
In a prospective longitudinal study design, details in jaw-neck kinematics and electromyography (EMG) activity changes in patients (women and men) referred for surgical correction of basal relations between the maxilla and…
- Trial name
- NCT05876169
- Testing
- Orthognathic surgery
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Umeå University
Heart Defects, Congenital
Remotely Monitored and Coached Cardiac Rehabilitation Northern Sweden
Supervised exercise is an essential component of contemporary center-based cardiac rehabilitation (CR) programs. Despite the proven effectiveness, uptake and adherence to supervised exercise-based CR (exCR) remains suboptimal…
- Trial name
- RECREATION (NCT03479957)
- Testing
- REMOTE-CR, Control
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Umeå University
Loneliness
Social Prescribing in Sweden (SPiS)
Loneliness among older adults has become an issue of public concern, as it is associated with increased morbidity and mortality. Yet, despite the urgency, there is little information on how to reduce or prevent loneliness.
- Trial name
- SPiS (NCT04336553)
- Testing
- Social prescribing in Sweden (SPiS)
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Umeå University
Cardiopulmonary Bypass, Blood Coagulation
Two Monitors for Measuring the Activated Clotting Time: A Comparison
In this observational study a comparison is made between two different monitors for measurement of the activated clotting time (ACT): mechanical versus biochemical techniques
- Conditions
- Cardiopulmonary Bypass, Blood Coagulation, Point-of-Care Testing
- Trial name
- NCT03203148
- Testing
- Point-of-Care ACT
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Umeå University
Chronic Diseases in Children
NICE - Nutritional Impact on Immunological Maturation During Childhood in Relation to the Environment
Role of the exposome on allergy, caries, and neurophysiological development in childhood.
- Trial name
- NICE (NCT05809479)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 1,950 people, healthy volunteers welcome
- Sponsor
- Umeå University
Breast Cancer, Surgery-Complications
Oxygen Partial Pressure After Breast Cancer Surgery
Hypoxia and reduced oxygen partial pressure is commonly occurring after abdominal surgery. This study aims to investigate whether similar changes also occur after breast cancer surgery.
- Conditions
- Breast Cancer, Surgery-Complications, Hypoxia
- Trial name
- NCT05737446
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Postoperative Complications, Abdominal Surgery
Postoperative Hypoxia and Body Position
The study aims at investigate whether the oxygen partial pressure is improved in the prone position postoperative after abdominal surgery. Included are 50 adults operated with abdominal surgery.
- Conditions
- Postoperative Complications, Abdominal Surgery, Hypoxia
- Trial name
- NCT05246605
- Testing
- change in body position
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Umeå University
Obstructive Sleep Apnea, Cardiovascular Disease
Cardiovascular Effects After CPAP Withdrawal for Obstructive Sleep Apnea
Background: Patients with obstructive sleep apnea run an increased risk of cardiovascular disease including hypertension. Continuous positive airway pressure (CPAP) is the first line of treatment.
- Trial name
- NCT02329470
- Testing
- Withdrawal of continuous positive airway pressure treatment
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Umeå University
Labor Pain
Gender of Anesthesiologist and Time to Labor Epidural
The goal of this retrospective cohort study is to learn about wether the gender of the anesthetist affects time to epidural anesthesia (EDA) for laboring women . The main questions it aims to answer are: 1.
- Trial name
- NCT05744570
- Testing
- Epidural anesthesia
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Umeå University
Postoperative Complications, Orthopedic Disorder
PaO2 and Lung Function After Orthopedic Surgery
Hypoxia and reduced oxygen partial pressure is commonly occurring after abdominal surgery. This study aims to investigate whether similar changes also occur after orthopedic surgery in the form of upper limb surgery.
- Trial name
- NCT05227573
- Testing
- Orthopedic surgery
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Lung Function, Postoperative Complications
Lung Function After Abdominal Surgery
The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.
- Conditions
- Lung Function, Postoperative Complications, Abdominal Surgery
- Trial name
- NCT04502420
- Testing
- Lung function before and after surgery
- Where
- Sweden
- Volunteers
- 59 people
- Sponsor
- Umeå University
Type2diabetes
Validation of Existing Diabetes Risk Models in a Swedish Population
The goal of this observational study is to validate existing non-invasive diabetes clinical prediction models in a Swedish population.
- Trial name
- NCT05609266
- Volunteers
- 115,642 people, healthy volunteers welcome
- Sponsor
- Umeå University
Pancreas Cancer, Pancreas Neoplasm
Survival, Quality of Life and Resectability in Locally Advanced Pancreatic Cancer
This study aims to assess overall survival, quality of life and resection rates in locally advanced pancreatic cancer
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Disease, Pancreas Adenocarcinoma
- Trial name
- SQUARE (NCT05356039)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Umeå University