Clinical trials: sponsored by Unity Health Toronto
Rotator Cuff Tear
The Impact of Psychological Factors on the Outcome of Surgical Repair for Rotator Cuff
The proposed study will be a multi-centre, prospective, observational cohort to determine if psychological well-being has an impact on the outcome of surgical repair for rotator cuff tears.
- Trial name
- IMPROVE (NCT03018210)
- Testing
- Surgical repair of the rotator cuff
- Where
- 5 sites in Canada
- Volunteers
- 267 people
- Sponsor
- Unity Health Toronto
Anemia, Iron Deficiency, Anemia of Chronic Disease
Hemoglobin Optimization to Prevent Transfusion and Adverse Events in Perioperative Patients With Iron Restricted Anemia
The HOPE-Hb trial is a phase II study to determine the feasibility and impact of a combination treatment (intravenous iron plus erythropoietin) versus intravenous iron treatment alone on preoperative hemoglobin concentration…
- Conditions
- Anemia, Iron Deficiency, Anemia of Chronic Disease, Hip Arthropathy, Knee Arthropathy
- Trial name
- HOPE-Hb (NCT03528564)
- Testing
- Iron sucrose, Epoetin Alfa
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2
Chronic subdural hematoma (CSDH), a common disease after minor head trauma, is characterized by blood collection in the subdural space, which can result in severe neurological impairment.
- Trial name
- TRACE-2 (NCT04898712)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Covid-19, ARDS
Prone Positioning for Patients on General Medical Wards With COVID19
COVID-PRONE is a multicenter, pragmatic, unblinded, 2-arm, parallel, randomized controlled trial seeking to compare the pre-emptive prone positioning (i.e.
- Trial name
- COVID-PRONE (NCT04383613)
- Testing
- Prone positioning
- Where
- 8 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Diabetic Nephropathies, Kidney Disease, Chronic
Molecular Analysis of Diabetic Kidney Disease Biopsies
Despite decades of research, the pathogenesis of human diabetic kidney disease remains largely unclear. Our goal is to use archived human kidney biopsy tissue from patients with and with diabetic nephropathy to identify new…
- Trial name
- NCT04029402
- Testing
- RNA sequencing
- Where
- 4 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Unity Health Toronto
Cardiac Arrhythmias, Atrial Fibrillation and Flutter
Increasing Detection of Sub-Clinical Atrial Fibrillation in Defibrillator Patients With the Use of a VDD-ICD Lead
This study aims to compare the Dx-ICD system (experimental) to standard VVI-ICD (control) on the ability to diagnose silent AF in patients without prior AF receiving an ICD for standard indications.
- Conditions
- Cardiac Arrhythmias, Atrial Fibrillation and Flutter, Cardiovascular Diseases, Implantable Cardioverter-Defibrillators
- Trial name
- Dx-AF (NCT03110627)
- Testing
- VDD ICD (experimental group), Single chamber VVI ICD (control group)
- Where
- 9 sites in Canada
- Volunteers
- 188 people
- Sponsor
- Unity Health Toronto
Age Related Macular Degeneration, Diabetic Macular Edema
Cytokine and Visual Outcome Variations in Eyes Receiving Ranibizumab
Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal ranibizumab in patients with neovascular age-related macular…
- Conditions
- Age Related Macular Degeneration, Diabetic Macular Edema, Macular Edema, Retinal Vein Occlusion
- Trial name
- COVERT (NCT03056092)
- Testing
- Intravitreal ranibizumab
- Where
- 2 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Unity Health Toronto
Age Related Macular Degeneration, Diabetic Macular Edema
Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept
Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal aflibercept in patients with neovascular age-related macular…
- Conditions
- Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Macular Edema
- Trial name
- COVARIANT (NCT03056079)
- Testing
- Intravitreal aflibercept
- Where
- 2 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Unity Health Toronto
Retinal Detachment, Metamorphopsia
Effect of Type of Head Positioning on Retinal Displacement in Vitrectomy for Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments especially those with a detached macula.
- Trial name
- DIAMOND (NCT04035343)
- Testing
- Face down positioning, Supine positioning
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Unity Health Toronto
Retinal Detachment, Metamorphopsia
Retinal Displacement Rates in Pneumatic Retinopexy Versus Pars Plana Vitrectomy For Primary Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments (RRDs) especially those with a detached macula.
- Trial name
- REVEAL (NCT04158622)
- Testing
- PnR + laser/cryotherapy, PPV + laser/cryotherapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Invasive Mechanical Ventilation, Critical Illness
Mechanical Ventilation Discontinuation Practices
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Conditions
- Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation
- Trial name
- IOS (NCT03955874)
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,868 people
- Sponsor
- Unity Health Toronto
Traumatic Knee Dislocation
Late Compared to Early Physiotherapy Following Knee Dislocation
A knee dislocation is an unusual and extremely serious injury and is defined as complete displacement of the tibia with respect to the femur, usually with disruption of 3 or more of the stabilizing ligaments.
- Trial name
- Co_Leap (NCT01296750)
- Testing
- Early Physiotherapy start
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Unity Health Toronto
Endoscopy, Gamification
Applying Gamification to Postgraduate Endoscopic Training
Simulation-based training curricula for gastrointestinal endoscopy have been developed and have been shown to be effective. It is possible that these curricula may be further improved.
- Conditions
- Endoscopy, Gamification, Simulation
- Trial name
- NCT03176251
- Testing
- Gamified-Integrated Curriculum
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Frailty, Transcatheter Aortic Valve Replacement
Physiological Reconditioning Program Administered Remotely in Patients Undergoing Transcatheter Aortic Valve Replacement: A Pilot Study
The PREPARE TAVR pilot study will examine the effects of remotely administered physiological reconditioning program (RAPR) on quality of life (QOL) and clinical outcomes at one year post TAVR in frail older adults.
- Conditions
- Frailty, Transcatheter Aortic Valve Replacement, Rehabilitation
- Trial name
- PREPARE-TAVR (NCT03801460)
- Testing
- Remotely administered physiological reconditioning program
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
Impact of an Interprofessional Shared Decision-making and Goal-setting Decision Aid for Patients With Diabetes
Diabetes care is complicated for people with diabetes as well as for health care providers: they have to watch their diet, exercise, take medications, checking blood sugars and blood pressure, get tests and see multiple doctors.
- Trial name
- NCT02379078
- Testing
- Shared decision-making aid, Generic hard copy diabetes resources, Generic online diabetes resources
- Volunteers
- 225 people
- Sponsor
- Unity Health Toronto
COVID, Corona Virus Infection
RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective Randomized Pilot Study
This research aims to assess the use of an experimental and non-invasive procedure, Remote Ischemic Conditioning (RIC), as an adjunct therapy in attenuating severe COVID-19 disease.
- Conditions
- COVID, Corona Virus Infection, Acute Lung Injury, Ischemia Limb
- Trial name
- NCT04659460
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Polyp Colorectal
An Integrated Management Pathway for Complex Colorectal Polyps
The purpose of this study is to evaluate the impact of implementing an integrated clinical care pathway for the diagnosis, referral, evaluation and treatment of large complex colorectal polyps on clinical outcomes
- Trial name
- NCT04576780
- Testing
- Integrated Large Complex Polyp Referral Pathway
- Volunteers
- 400 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis, Burkholderia Cepacia Infection
Tobramycin Inhalation Powder (TIP) in Cystic Fibrosis Patients Infected With Burkholderia Cepacia Complex
The objective of this study is to determine if tobramycin inhalation powder (TIP) can reduce the amount of Burkholderia Cepacia Complex (BCC) species - type of bacteria, in the sputum of cystic fibrosis patient.
- Trial name
- NCT02212587
- Testing
- TOBI
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Hysteroscopy Surgery, Informed Consent
Assessing the Impact of a Patient Education Platform to Augment the Informed Consent Process for Obstetrics and Gynecology Procedures
Over the past few decades, there has been a shift in the informed consent process, whereby the focus is centered on patient comprehension, preparedness and satisfaction.
- Trial name
- NCT04614688
- Testing
- Patient Education Platform
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto
Depression, Anhedonia
Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Pre- and Post-Desvenlafaxine Treatment
Anhedonia (the lack of pleasure in normally pleasurable things) is a common symptom of major depressive disorder (MDD), and it may impact how patients with depression experience reward.
- Trial name
- NCT02859103
- Testing
- Desvenlafaxine
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto