Clinical trials: sponsored by Unity Health Toronto
Subarachnoid Hemorrhage, Aneurysmal
Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a special type of stroke that typically results from a ruptured intracranial aneurysm, a weakening in the wall of a blood vessel.
- Trial name
- NCT01865630
- Testing
- Etanercept
- Where
- Canada
- Sponsor
- Unity Health Toronto
Peripheral Arterial Disease
Personalizing Aspirin Therapy in Peripheral Arterial Disease Patients
Antiplatelet therapies are important to decrease the morbidity and mortality associated with Peripheral Arterial Disease (PAD) through the prevention of thrombus formation.
- Trial name
- NCT04269863
- Testing
- Aspirin
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Immune Thrombocytopenia
Proof-of-Concept: A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia
Immune Thrombocytopenia (ITP) is a disorder resulting in impaired platelet production and enhanced destruction on the basis of autoantibody-mediated mechanisms. Patients with ITP are at increased risk of bleeding and infection.
- Trial name
- NCT03520049
- Testing
- Oseltamivir
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Pulmonary Arteriovenous Malformations
Reperfusion of Pulmonary Arteriovenous Malformations After Embolotherapy
AVMs are abnormal collections of blood vessels which can occur in any part of the body including the lungs. These blood vessels are weakened and can rupture anytime causing bleeding which can be massive, leading to…
- Trial name
- NCT01856842
- Testing
- Angiography and embolotherapy
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Full Thickness Rotator Cuff Tear
Latissimus Dorsi Tendon Transfer or Partial Arthroscopic Repair of Massive Rotator Cuff Tears
A massive tear of the rotator cuff is a debilitating condition that causes pain, significant impairments in strength, and resultant loss of activity of the affected arm.
- Trial name
- NCT01481480
- Testing
- Latissimus dorsi tendon transfer, Arthroscopic repair
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Uterine Artery Flow
Uterine Artery Doppler Changes
In uncomplicated pregnancies, the uterine spiral arteries undergo a series of structural changes that result in a low resistance in the uterine arteries as pregnancy progresses.
- Trial name
- NCT03064698
- Testing
- Post-partum Doppler ultrasound
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Multiple Sclerosis
Medical Education for Better Multiple Sclerosis Outcomes
The main objectives of this study are: i) To design an educational tool to train physicians in overcome cognitive factors associated with therapeutic inertia.
- Trial name
- EDUCAR MS (NCT03134794)
- Testing
- Educational intervention applying the traffic light system (TLS)
- Where
- 4 sites in Argentina, Canada and 2 more
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
COVID-19
Direct Income SupporT and Advice Negating Spread of Epidemic COVID-19: a Randomized Controlled Trial
This is a clinical trial of a cash transfer on symptoms consistent with COVID-19 and adherence to physical distancing guidance.
- Trial name
- DISTANSE COVID (NCT04359264)
- Testing
- Cash transfer
- Where
- 2 sites in Canada
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Response Rates
Contacting Authors to Retrieve Individual Patient Data
The objective of this study is to examine the impact of incentivizing authors of RCTs that are eligible for a systematic review and meta-analysis, versus usual contact strategies to obtain original IPD
- Trial name
- NCT02569411
- Testing
- Financial Incentive
- Volunteers
- 129 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Prospective Pilot Study of Floseal for the Treatment of Anterior Epistaxis in Patients With (HHT)
Current management strategies for severe and recurrent epistaxis secondary to Hereditary hemorrhagic telangiectasia (HHT) include surgical procedures, and uncomfortable nasal packing, both of which are often only short-term…
- Trial name
- NCT02638012
- Testing
- Floseal, Packing
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Type 2 Diabetes
Fibre Grain Herb Trial in Type 2 Diabetes
Despite the availability of multiple medications for the treatment of Type 2 diabetes, patients often continue to have difficulty attaining blood glucose targets and managing cardiovascular disease risk factors.
- Trial name
- FIGHT (NCT02553382)
- Testing
- Dietary, Herbal, Positive Control
- Where
- 2 sites in Canada, Croatia
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Embolism, Femoral Fractures
Effect of a Novel Reamer-Irrigator-Aspirator on the Incidence of Fat Embolism
The purpose of this study is to determine the effect on the incidence of fat emboli when using a Reamer-Irrigator Aspirator during reamed IM nail fixation of femoral shaft fractures
- Trial name
- RIA (NCT00509171)
- Testing
- Reamer Irrigator Aspirator
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Uptake of Systematic Review Evidence
Testing New Formats for the Presentation of Research Evidence to Health Care Managers and Policy Makers
The purpose of this project is to identify and use our knowledge on the barriers and facilitators to using systematic reviews (SR) by health care managers (HCM) and policy markers (PM) to develop and test a novel format for…
- Trial name
- NCT03041454
- Testing
- Novel systematic review format
- Where
- Canada
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Ductus Arteriosus
The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Labour at Term
The exact mechanism stimulating the parturition in humans is still relatively unknown. Prostaglandins, by mediating cervical ripening and early stimulation of myometrial contractions, are likely to play a major role in the…
- Trial name
- NCT03073460
- Testing
- Ultrasound examination
- Sponsor
- Unity Health Toronto
Gestational Diabetes
The Use of the CPR to Predict Adverse Outcomes in GDM Pregnancies
The cerebro-placental ratio (CPR) is a tool for assessment of fetal wellbeing in the management of the growth restricted fetus. CPR is the ratio of the fetal middle cerebral artery pulsatility index (PI) to the umbilical artery…
- Trial name
- CPR GDM (NCT03072563)
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- Unity Health Toronto
Renal Transplant
Pregnancy Outcomes in Renal Transplant Recipients
This is a retrospective study involving all patients with a history of renal transplant that attended antenatal clinics at various Toronto hospitals and subsequently delivered between January 2000 and December 2014.
- Trial name
- NCT03073434
- Volunteers
- 17 people
- Sponsor
- Unity Health Toronto
Gestational Diabetes Mellitus
The Impact of Activity Promoting Video Games on Glycemic Control in Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) affects up to 3-5% of all pregnancies. When diagnosed with GDM, women undergo nutritional counseling, blood sugars monitoring and are encouraged to exercise regularly.
- Trial name
- NCT03073551
- Testing
- Wii Group
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Medication Adherence, Inappropriate Prescribing
Carefully seLected and Easily Accessible at No Charge Medications
This trial evaluates the effect of providing primary care patients with free and convenient access to a set of essential medicines.
- Conditions
- Medication Adherence, Inappropriate Prescribing, Diabetes, Hypertension
- Trial name
- CLEAN-Meds (NCT02744963)
- Testing
- Free and convenient medicine access
- Where
- 3 sites in Canada
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Shoulder Dislocation
Non-operative Versus Operative Treatment of Acute Acromioclavicular Joint Dislocation
The purpose of this study is to compare non-operative treatment versus operative treatment in patients who suffer a complete, acute acromioclavicular (AC) joint dislocation.
- Trial name
- ACJoint (NCT00594841)
- Testing
- Open Reduction Internal Fixation of AC joint dislocation, Non operative treatment of AC joint dislocation (sling)
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Unity Health Toronto
Humeral Fractures, Ulnar Nerve Compression
Simple Decompression Versus Anterior Transposition of the Ulnar Nerve
Both simple decompression and anterior transposition of the elbow nerve (ulnar nerve) for acute displaced fractures of the elbow (distal humerus) treated with plate fixation are currently used by surgeons.
- Trial name
- NCT01051869
- Testing
- Simple decompression, anterior subcutaneous transposition
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Unity Health Toronto