Clinical trials: sponsored by Unity Health Toronto
Critically Ill
Screening Elderly Patients for Weaning
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- NCT02243449
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Unity Health Toronto
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Kidney Stones
Narrow Versus Wide Focal Zones for Shock Wave Lithotripsy of Renal Calculi
Shockwave lithotripsy (SWL) is a safe, non-invasive treatment for renal calculi. During SWL energy is focused on in order to break kidney stones and this energy can be varied in size from a narrow (or small) focal zone to a wide…
- Trial name
- NCT01226875
- Testing
- SWL: Shock Wave Lithotripsy Intervention
- Where
- 3 sites in Canada
- Volunteers
- 275 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease after minor head trauma, especially in elderly patients. This medical condition is characterized by blood collection in the subdural space, which can result in severe…
- Trial name
- TRACE (NCT03280212)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
ST Elevation Myocardial Infarction, Coronary Stenting
Revascularization StrategIes for ST Elevation Myocardial Infarction Trial
This study is being conducted in patients with a major heart attack caused by a blocked artery undergoing Percutaneous Coronary Intervention (PCI) to open up the blockage.
- Conditions
- ST Elevation Myocardial Infarction, Coronary Stenting, Primary Angioplasty
- Trial name
- ASSIST-MI (NCT03263468)
- Testing
- Same sitting PCI with complete revascularization, Staged PCI with complete revsacularization >48 hours pf primary PCI
- Volunteers
- 3,520 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
The Effect of NVFS on GC in Individuals With DM: SR & MA of RCTs
Purpose of Study (The Effect of Non-Viscous Fibre Supplementation on Glycemic Control (NVFS \& GC) in Individuals with Diabetes Mellitus.
- Trial name
- NVFS&GC (NCT03259724)
- Where
- Canada
- Volunteers
- 514 people
- Sponsor
- Unity Health Toronto
Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus)
Effect of Viscous Soluble Fibres on Body Weight
Abstract: Background: Obesity is a global pandemic affects all age groups and is independent risk factors for most chronic diseases. Dietary intervention is an essential component of obesity management.
- Conditions
- Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus), General Population
- Trial name
- NCT03257449
- Testing
- Viscous Fibre
- Where
- Canada
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cough, Larynx
The Efficacy of Capsaicin Sensitivity Testing in Patients With Irritable Larynx Syndrome
Irritable larynx syndrome (ILS) is a hyperkinetic laryngeal dysfunction that is characterized by a persistent cough, voice changes, or breathing difficulties, which are often triggered by an irritant.
- Trial name
- NCT02065128
- Testing
- Capsaicin cough challenge test
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
Respiratory Mechanics Registry for ARDS Patients
This registry was proposed to investigate the epidemiology of respiratory mechanics in patients with ARDS through collecting data from a QI project which was constituted with systematic assessments of respiratory mechanics and…
- Trial name
- NCT02623192
- Testing
- Patients who have performed the ARDS pulmonary function test
- Where
- 2 sites in Canada, Italy
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Sex Steroids
Effect of Pregnancy on Androgenic Steroids in Different Genetic Panels
Androgens are important sex steroids in women. Androgens influence protein synthesis and muscle growth, are involved in maturation of the reproductive organs, have a fat reducing effect , have a negative effect on the serum lipid…
- Trial name
- NCT03064412
- Testing
- Urine sample collection, Saliva collection
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Voiding Dysfunction After Pelvic Organ Prolapse Surgery
Post-operative Voiding Dysfunction: the Preferred Method for Catheterization
This study is divided into two parts. The first part is a prospective observational study of patients undergoing pelvic organ prolapse (POP) surgery.
- Trial name
- NCT01597544
- Testing
- CISC instruction pre-operatively
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Stage I-IV Breast Cancer (Neo-adjuvant, Adjuvant, Locally Advanced and Metastatic)
Assessment of Cardiotoxicity by Cardiac Magnetic Resonance (CMR) in Breast Cancer Patients Receiving Trastuzumab
Herceptin has shown significant improvement in breast cancer therapy and improved survival of patients over-expressing the HER-2 protein by 50%.
- Trial name
- NCT01022086
- Testing
- Cardiac MRI, Biomarker Testing
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Obesity
Obesity Heterogeneity Study
The investigators will assess the heterogeneity of obese individuals in the United States to help researchers, clinicians and policymakers to establish goals for obesity treatment and identify whether differing interventions may…
- Trial name
- NCT03155880
- Volunteers
- 1,685 people
- Sponsor
- Unity Health Toronto
Endoscopy Simulation
Impact of a Simulation-based Training Curriculum of Non-technical Skills on Colonoscopy Performance
The investigators aim to test a curriculum of non-technical skills (NTS) training for simulation-based training of colonoscopy. There is no known literature to date on the optimal approach on how to teach NTS in endoscopy.
- Trial name
- NCT02877420
- Testing
- Non-Technical Skills Training Curriculum, Conventional Simulation Training Group
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Hypercholesterolemia
Magnetic Resonance Imaging-Portfolio Diet Study #7
Presently in Canada, 29% of deaths are due to cardiovascular disease (CVD), costing $20.9 billion annually. The investigators have, therefore, brought together an unique network of investigators at different stages in their…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Diabetes, Metabolic Syndrome
- Trial name
- MRIPD#7 (NCT02078635)
- Testing
- Portfolio Plus Diet, DASH-like (high fibre) dietary advice
- Where
- 4 sites in Canada
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Type 2 Diabetes
Enhanced Multicenter Dietary Portfolio Study
"Is it possible to recruit and retain up to 200 participants in a Randomize Control Trial (RCT) of high impact lifestyle approach of diet and exercise designed to significantly reduce cardiovascular events in middle-aged and…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes, Hypercholesterolemia
- Trial name
- EDP8 (NCT01954472)
- Testing
- Enhanced portfolio plus structured exercise, High fiber diet plus routine exercise
- Where
- 4 sites in Canada
- Sponsor
- Unity Health Toronto
End-stage Renal Disease, Left Ventricular Hypertrophy
In-Centre Nocturnal Hemodialysis (INHD): A Long-Term Follow-Up Study
Background: In 2010, approximately 39000 Canadians had end-stage renal disease (ESRD), and the prevalence rate of dialysis has increased by 189% over the past 2 decades.
- Trial name
- INHD (NCT02684773)
- Testing
- Conventional Hemodialysis, In-centre Nocturnal Hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency, Ventilator-Induced Lung Injury
APRV/BIPAP With Spontaneous Breathing on Lung Protection
Mechanical ventilation (MV) is a cornerstone of management of acute respiratory failure, but MV per se can provoke ventilator-induced lung injury (VILI), especially in acute respiratory distress syndrome (ARDS).
- Trial name
- APRV/BIPAP (NCT02071277)
- Testing
- Pressure targeted modes
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
HIV Positive Pregnant Women
Positive Pregnancy Program
The Positive Pregnancy Program is an innovative, unique, interprofessional model of care for HIV-positive pregnant women. This program has been in place at St. Michael's Hospital for five years.
- Trial name
- P3 (NCT03073421)
- Testing
- Qualitative interview
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Coronary Artery Disease
Optimizing Timing of CABG in Patients Presenting With ACS and Treated With Ticagrelor
The administration of Ticagrelor have demonstrated superiority to Clopidogrel in patients presenting with acute coronary syndrome (ACS) and remains a first line therapy as an adjunct to aspirin for patients admitted with ACS.
- Trial name
- CABG-TIME (NCT02627521)
- Testing
- PRU guided CABG, CABG per standard of care, VerifyNow assay
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Unity Health Toronto