Clinical trials: sponsored by Unity Health Toronto
Hypertension, Blood Pressure
Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation
Ginseng has been used for many years in a wide array of anecdotal medicinal properties. Animal and limited clinical research points to the vascular effects of Korean Red Ginseng (KRG).
- Conditions
- Hypertension, Blood Pressure, Endothelial Function
- Trial name
- ESGC (NCT00728221)
- Testing
- Korean Red Ginseng, Korean Red Ginseng (Panax ginseng), Cornstarch
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hepatopulmonary Syndrome
A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome
The hepatopulmonary syndrome (HPS)and pre-HPS is a disease seen in patients with chronic liver disease, whereby patients develop dilations in the blood vessels of the lungs, resulting in low oxygen levels and shortness of breath.
- Trial name
- NCT00362752
- Testing
- Norfloxacin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
Education, Medical, Critical Care Ultrasonography
Focused Cardiac and Lung Ultrasound in Anesthesia/Critical Care - The Role of Self-directed Simulation-assisted Training Compared to a Traditional Supervised Approach
The purpose of this study is to determine whether a self-directed and simulation-based lung ultrasound (LUS) and focused cardiac ultrasound (FCU) curriculum is efficacious on anesthesia trainees' image acquisition skills and…
- Trial name
- NCT01972698
- Testing
- Self-directed and simulation-assisted training, Traditional apprenticeship training
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Myocardial Infarction
Ticagrelor for PCI Post Thrombolysis
Ticagrelor is a first line therapy along with aspirin for patients undergoing primary PCI for STEMI. However, many patients are still treated with fibrinolytic therapy and the safety and efficacy of Ticagrelor has not been…
- Trial name
- SETFAST (NCT01930591)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 5 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
LDL Cholesterol
Effect of Viscous Soluble Fibers on Serum Cholesterol Levels
Research over the past several decades have linked the intake of dietary fiber with lower blood cholesterol levels. The distinction between soluble and insoluble fiber fractions emerged shortly after and there is now a general…
- Trial name
- CHOL-META (NCT02068248)
- Testing
- Soluble Fibre
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV, Human Immunodeficiency Virus
PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5
Canada continues to see an unrelenting stream of new HIV diagnoses, with a disproportionate burden among gay, bisexual, and other MSM in major centers such as Toronto.
- Trial name
- PREP-5 (NCT02149888)
- Testing
- Tenofovir/emtricitabine
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Early Detection of Cancer, Cancer
Comparing Methods of Recall for Cancer Screening in Primary Care: a Pragmatic Clinical Trial
This randomized trial aims to understand how effective a reminder letter is compared to a reminder phone call in improving breast, cervical and colorectal cancer screening rates and reducing screening disparities.
- Conditions
- Early Detection of Cancer, Cancer, Socioeconomic Status
- Trial name
- NCT02457143
- Testing
- Letter, Phone call
- Where
- Canada
- Volunteers
- 5,270 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Overweight
Effectiveness and Safety of Salba on Weight Loss in Overweight Individuals With Type 2 Diabetes
Canadian statistics indicate that the incidence of obesity is increasing and that the occurrence of diabetes in obese individuals is 5-fold greater than those with a healthy weight, making weight control in this population…
- Conditions
- Diabetes Mellitus, Overweight, Obesity
- Trial name
- LOSS (NCT01403571)
- Testing
- Salba (Salvia hispanica L.), Oat-based Control
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type II Diabetes Control
Effect of Ginseng in Type 2 Diabetes
Objective: We aim to evaluate longer term efficacy and safety of AG as an add-on therapy in patients with type 2 diabetes controlled by conventional treatment.
- Trial name
- NCT02923453
- Testing
- CNT 2000 American ginseng extract
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Unity Health Toronto
Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors
EUS-FNB vs. Single-incision Needle-knife (SINK) Biopsy for Gastrointestinal SELs
Sub epithelial lesions (SELs) of the gastrointestinal (GI) tract are commonly identified during routine endoscopy. Most of these lesions are benign.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Gastrointestinal Stromal Tumors, Gastrointestinal Neoplasms
- Trial name
- NCT02866045
- Testing
- EUS-guided fine needle biopsy, Single incision needle knife biopsy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
End Stage Renal Disease
The Use of Furosemide in Patients on Dialysis
Patients often begin dialysis taking diuretics (stimulate the kidney to excrete salt and water). Once on dialysis, these drugs are often continued.
- Trial name
- NCT01815892
- Testing
- Withdrawal of furosemide, furosemide administration
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Unity Health Toronto
Self-regulation, Forethought
Exploring Self-regulatory Processes in Anesthesiologists During Massive Transfusion
The purpose of the project is to investigate the function of self-regulatory processes in anesthesiologists and how application of these processes influence performance in a crisis situation.The investigators intend to explore…
- Conditions
- Self-regulation, Forethought, Performance
- Trial name
- NCT02199210
- Testing
- Prompting forethought
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Acute Myocardial Infarction
Revascularization Strategies for STEMI; The CMR Endpoint Study
Revascularization strategies for ST elevation myocardial infarction (STEMI) study (ASSIST-CMR) will compare the effects of two revascularization strategies [same sitting multivessel primary PCI (SS-PCI) and culprit vessel only…
- Trial name
- ASSIST-CMR (NCT01818960)
- Testing
- IRA-PCI, SS-PCI
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Unity Health Toronto
Blood Pressure
Effect of High-carbohydrate or High-monounsaturated Fat on Blood Pressure: Meta-analysis of Randomized Clinical Trials
High saturated fat acids diets are associated with elevated blood pressure which is associated with cardiovascular morbidity and mortality.
- Trial name
- CHO-MUFA (NCT02626325)
- Testing
- High-carbohydrate or High-monounsaturated fat diets
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes
A Computer-Based Simulation of DKA Management
A 2-by-2 factorial cluster randomized controlled trial was performed to: 1) Compare the effects of supervised (coached) versus unsupervised (no coach) administration of the DKA simulator on trainees' knowledge of DKA management…
- Trial name
- DKA (NCT02799563)
- Testing
- Coach, Preselected number of cases, Coach, Self-selected number of cases, No coach, Preselected number of cases
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Agitation
Treating Acutely Agitated Patients With Asenapine Sublingual Tablets
Our proposal is to administer asenapine to patients who are clinically agitated and in need of immediate intervention. At present there are no controlled studies that we know of that explores the use of asenapine for this…
- Trial name
- NCT01400113
- Testing
- Asenapine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
C.Surgical Procedure; Cardiac
HELIox CardiOPlegia Trial During Cardiac surgERy
The HELICOPTER-1 Trial is a single centre pilot study to determine the feasibility of administering Heliox in cardioplegia during cardiac surgery and whether it has the potential to reduce the incidence and severity of myocardial…
- Trial name
- HELICOPTER-1 (NCT02745951)
- Testing
- Heliox, Standard of care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Healthy
Comparison of Dietary Fats on Vascular Parameters
The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels.
- Trial name
- COIL (NCT01876394)
- Testing
- Coconut Oil, Canola Oil, Grapeseed Oil
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type 2 Diabetes Mellitus
ALA on Glycemic Control in T2DM Participants
With the emerging worldwide epidemic of type 2 diabetes, dietary recommendations to improve diabetes management have been emphasized in the scientific community.
- Trial name
- NCT02701894
- Testing
- Alpha-Linolenic Acid
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Blood Pressure
Effect of Ginseng on Blood Pressure
To determine the effect of ginseng on blood pressure control.
- Trial name
- NCT01913210
- Testing
- Ginseng
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto