Clinical trials: sponsored by Unity Health Toronto
Chronic Neuropathic Pain
Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial
This is a Health Canada regulated internal pilot study designed to assess the feasibility, tolerability, and preliminary efficacy of 3, 4-methylenedioxymethamphetamine hydrochloride capsules-AT for chronic neuropathic pain to…
- Trial name
- EASEPain (NCT07301632)
- Testing
- 3,4-Methylenedioxymethamphetamine, Methylphenidate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
HIV, Chlamydia
National Rapid TLC: Testing and Linkage to Care
The goal of this cross-sectional study is to learn if the GeneXpert system is a practical system for HIV and STBBI testing in community-based organizations and health clinics.
- Conditions
- HIV, Chlamydia, Gonorrhea, HCV
- Trial name
- NCT07730801
- Testing
- Xpert® HIV-1 Qual XC
- Where
- 2 sites in Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Informed Consent, Patient Education
Digital-Supported Versus Standard Consent for Advanced Therapeutic Endoscopy
This study will evaluate whether a digital-supported informed consent process improves patient understanding before advanced therapeutic endoscopy procedures.
- Conditions
- Informed Consent, Patient Education, Patient Comprehension, Therapeutic Endoscopy
- Trial name
- DIGI-CONSENT (NCT07723105)
- Testing
- Digital-Supported Informed Consent Pathway, Standard Physician-Led Informed Consent
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- Unity Health Toronto
Gastric Varices Bleeding, Gastric Varices
Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices
This study compares two endoscopic ultrasound-guided treatments for gastric varices, which are enlarged veins in the stomach that can bleed. Both treatments use small coils placed into the varix.
- Conditions
- Gastric Varices Bleeding, Gastric Varices, Portal Hypertension
- Trial name
- CoAGS-GV (NCT07699354)
- Testing
- EUS-Guided Coil Embolization With Cyanoacrylate Glue and Lipiodol, EUS-Guided Coil Embolization With Absorbable Gelatin Sponge
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Unity Health Toronto
Chronic Obstructive Pulmonary Disease (COPD), Smoking Cessation
Personalized Smoking Cessation Infographic in COPD
This study assesses the effect of a personalized smoking cessation infographic on physician smoking cessation counseling rates and smoking cessation pharmacotherapy prescription rates.
- Trial name
- NCT04119934
- Testing
- Smoking Cessation Intervention Tool
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Unity Health Toronto
Kidney Disease, Chronic, Diabetes
Glucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis
This study aims to determine if GLP1RA is safe and tolerable in maintenance dialysis population, adherence, and feasibility of a larger definitive cardiovascular outcome trial in this population.
- Conditions
- Kidney Disease, Chronic, Diabetes, Dialysis, End Stage Kidney Disease (ESRD)
- Trial name
- GUARD-1 (NCT07017270)
- Testing
- Semaglutide Pen
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Cardiac Conditions, Connective Tissue Diseases
The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services
Genetic testing (GT) (including targeted panels, exome and genome sequencing) is increasingly being used for patient care as it improves diagnosis and health outcomes.
- Conditions
- Cardiac Conditions, Connective Tissue Diseases, Retinal Disease, Epilepsy in Children
- Trial name
- NCT06455384
- Testing
- Genetics Navigator, Standard Care with Genetics Professionals
- Where
- 3 sites in Canada
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homelessness, Youth
Supporting Social & Economic Equity, Disrupting Cycles of Homelessness, And Nurturing Growth & Empowerment
The goal of the SEED CHANGE pilot study is to co-design and test a wraparound intervention for young people transitioning away from homelessness.
- Trial name
- SEED CHANGE (NCT07419282)
- Testing
- Wraparound Intervention
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Unity Health Toronto
Acetabular Fracture
Geriatric Acetabular fracTures: Open Reduction Internal Fixation Versus Replacement
Management of acetabular (hip) fractures in the geriatric population can be very challenging because of pre-existing medical comorbidities, pre-existing osteoporosis and increased risk of mortality.
- Trial name
- GATOR (NCT03713853)
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
MDD
Functional Electrical Stimulation for MDD
This study aims to determine whether Functional Electrical Stimulation (FES) of the facial muscles is a safe and effective treatment for major depressive disorder (MDD).
- Trial name
- NCT07629050
- Testing
- Functional Electrical Stimulation (FES)
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia, Nosebleeds
Sirolimus for Nosebleeds in HHT
This pilot study is to determine the safety and efficacy of oral sirolimus (blood trough level 6-10ng/ml) in patients with HHT that are experiencing moderate or severe epistaxis.
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Nosebleeds, Epistaxis
- Trial name
- NCT05269849
- Testing
- Sirolimus
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
MDD
Take-home Functional Electrical Stimulation for MDD
The purpose of this study is to learn whether Functional Electrical Stimulation (FES) of the facial muscles is effective in treating major depressive disorder (MDD) and to develop a model for take-home delivery.
- Trial name
- NCT06261177
- Testing
- Functional Electrical Stimulation (FES)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Subdural Hematoma
The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma
Subdural hematoma (SDH) is a common condition experienced after head injury. Blood collects on the surface of the brain, causing headaches which can progress to confusion, weakness, or even coma.
- Trial name
- TRACE (NCT05713630)
- Testing
- Tranexamic acid (TXA)
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Unity Health Toronto
Wellness, Burnout, Caregiver
Evaluating the Impact of Resource Navigators to Support LTC and RH Staff During and Beyond COVID-19
The goal of this clinical trial is to test how well resource navigators help long-term care and retirement home staff access the various health and wellness resources available to them and the effects that this has on their…
- Conditions
- Wellness, Burnout, Caregiver, Burnout, Professional, COVID-19
- Trial name
- NCT05677997
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homelessness, Youth
Transitioning Youth Out of Homelessness 2.0 (TYOH 2.0)
Introduction: This 12-month pilot randomized controlled trial (RCT) built on previous community-engaged work and explored whether portable rent subsidies and an intervention targeting identity capital (purpose, control…
- Trial name
- NCT05781503
- Testing
- Identity Capital Intervention (Coach + Co-designed Leadership Guide), Monthly Rent Subsidies
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Trauma
SWiFT Canada (Study of Whole Blood in Frontline Trauma)
Traumatic injuries affect people of all ages, races, and socioeconomic backgrounds. The Global Burden of Disease study showed that globally in 2019, there were more than 4.4 million deaths due to injury.
- Trial name
- SWiFTCanada (NCT06495294)
- Testing
- Whole Blood, RBC + plasma
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Distal Femur Fracture
DIFFIR - Geriatric Distal Femur Fixation Versus Replacement
The current standard of care for most intra-articular distal femur fractures (above the knee joint) in geriatric patients is a surgical fixation using plates and screws to hold the fracture pieces in the correct position, until…
- Trial name
- DIFFIR (NCT04076735)
- Testing
- Distal femoral replacement, Surgical Fixation (ORIF)
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
Homeless Persons, Case Management
Navigator Program for Homeless Adults
Individuals experiencing homelessness often have complex health and social needs. This population also faces disproportionate systemic barriers to accessing health care services and social supports, such as not having primary…
- Conditions
- Homeless Persons, Case Management, Primary Care, Hospital Readmission
- Trial name
- NCT04961762
- Testing
- Navigator Program
- Where
- Canada
- Volunteers
- 656 people
- Sponsor
- Unity Health Toronto
Social Determinants of Health, Healthcare Disparities
Social Equity Data in Primary Care: How Best to Collect Data From Hard-to-Reach Populations
The goal of this clinical trial is to learn whether a community-based outreach approach can improve the collection of social and demographic information in adult primary care patients who may be harder to reach through standard…
- Conditions
- Social Determinants of Health, Healthcare Disparities, Primary Health Care, Health Equity
- Trial name
- NCT07550101
- Testing
- Community health surveyor
- Where
- Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Open Abdomen, Mechanical Ventilation
Effects of AbClo Fascial Approximation Device in Patients With Open Abdomen on Respiratory Mechanics
Patients who underwent an abdominal surgery and had the abdomen remain open are called to have an "open abdomen". To limit the risk of further widening of their wounds, surgeons can use AbClo, which is a non-invasive abdominal…
- Trial name
- AbClo-Resp (NCT07154589)
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto