Clinical trials: sponsored by Unity Health Toronto
Coronary Heart Disease, Congestive Heart Failure
Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death
Recent ACC/AHA/ESC guidelines recommend prophylactic ICD implantation in most patients with coronary heart disease and LVEF < 40%.
- Conditions
- Coronary Heart Disease, Congestive Heart Failure, Ventricular Dysfunction, Low Cardiac Output
- Trial name
- SMART-ICD (NCT00524862)
- Testing
- Optimized medical therapy, Implantable Cardioverter Defibrillator
- Where
- 10 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Unity Health Toronto
Kidney Stones
A Randomized Study of Whether Alfuzosin(Xatral) Helps in the Passage of Kidney Stones
Patients who present for the first time to Emergency Room with renal colic due to a distal ureteral calculus (as diagnosed with spiral CT scan and KUB) will be randomized to receive Xatral 10mg po once a day or placebo once…
- Trial name
- NCT00583258
- Testing
- Alfuzosin (Xatral)
- Where
- Canada
- Sponsor
- Unity Health Toronto
Diabetes Mellitus Type 2
Metabolic and Therapeutic Effects of American and Korean Red Ginseng in the Treatment of Type 2 Diabetes
The study is a 2 phase double blind randomized placebo control trial. The objective is to asses the metabolic and therapeutic effects of American Ginseng (Panax quinquefolius L.) extract and Korean Red Ginseng (steamed Panax C.A.
- Trial name
- NCT00728403
- Testing
- American Ginseng (Panax quinquefolius L.) and Korean Red Ginseng (steamed Panax C.A. Meyer), American Ginseng (Panax quinquefolius L.), Wheat Bran
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Hypertension
The Evaluation and Standardization of Ginseng and Its Components for Blood Pressure Regulation
While the use of herbals is increasing considerably, their efficacy and safety in the humans remains largely unknown. This surge in demand prompts a call for its evaluation.
- Trial name
- NCT00730951
- Testing
- Korean Red Ginseng, Corn Starch
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Pituitary Neoplasms, Prolactinoma
Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools
The purpose of this research study is to determine the utility of educational materials designed to inform patients of their pituitary condition, in an effort to assist the patients, families, and staff deal with pituitary…
- Conditions
- Pituitary Neoplasms, Prolactinoma, ACTH-Secreting Pituitary Adenoma, Gigantism
- Trial name
- NCT01775332
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
End-stage Renal Disease
Two phosphAte taRGets in End-stage Renal Disease Trial (TARGET)
Patients with end-stage renal disease (ESRD) who have elevated serum phosphate (P) levels have significantly higher mortality rates compared to those with normal P.
- Trial name
- TARGET (NCT01994733)
- Testing
- Calcium carbonate ( Intensive phosphate control), Calcium carbonate (Liberalized phosphate control)
- Where
- 5 sites in Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Infectious Disease, Cardiovascular Disease
Promoting Evidence-Based Decision-Making in India: District Evaluation Study on Health
The purpose of this study is to assess the impact of disseminating information on comparative performance, along with actionable messages on how to improve health outcomes, to district-level decision-makers in India using a…
- Trial name
- DESH (NCT01003587)
- Testing
- District health information package
- Where
- 2 sites in Canada, India
- Volunteers
- 594 people
- Sponsor
- Unity Health Toronto
Cardiac Arrest
The Strategies for Post Arrest Resuscitation and Care Network
Background: One of the 2010 Impact Goals of the Emergency Cardiac Care (ECC) Committee of the American Heart Association is to double survival from cardiac arrest.
- Trial name
- SPARC (NCT00683683)
- Testing
- Knowledge Translation
- Volunteers
- 32 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
A Diaphragmatic Electrical Activity Based Optimization Strategy During Pressure Support Ventilation
Pressure support (PS) is a commonly used mode of ventilation which is triggered based upon the patient's own inspiratory efforts. For the most part, pressure support is well tolerated by patients.
- Trial name
- NCT02067403
- Testing
- Pressure-support Eadi optimization
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis Pulmonary Exacerbation
Pharmacokinetic Study of Extended Infusion Meropenem in Adult Cystic Fibrosis Patients
Meropenem is an intravenous antibiotic commonly used to treat acute exacerbation of respiratory infections in cystic fibrosis. The research study aims to determine if a different method of infusing the drug over 3 hours or…
- Trial name
- NCT01158937
- Testing
- Meropenem Infusion
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Unity Health Toronto
Kidney Stone
The Effect of Ureteric Stent Tethers on Patient Symptoms and Urinary Infection
RESEARCH QUESTION Do ureteric stents with tethers, left in-situ for 1-2 weeks, increase the rate of stent bacterial colonization, urinary bacterial colonization and stent related lower urinary tract symptoms compared to stents…
- Trial name
- NCT01812772
- Testing
- Double J-stent with a long tether, Double J-stent without a long tether
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Surgical Technical Skill, Technical Errors in Surgery
Comprehensive Surgical Coaching
Simulation in surgical skills training is widely accepted as a necessary step to improve surgical training outside the operating room. Simulation predominately focuses on teaching a specific task or procedure.
- Trial name
- NCT01875679
- Testing
- Comprehensive Surgical Coaching, Conventional Surgical Training
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cystic Fibrosis, Vitamin D Deficiency
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients
The main aim of the research question to test the primary hypothesis of this study, namely, Does 12 weeks of an additional 5000 IU daily of cholecalciferol increase serum 25OHD levels in adults with Cystic Fibrosis (CF) who have…
- Trial name
- NCT00685971
- Testing
- 5000 IU of cholecalciferol
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Chronic Kidney Disease
The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis
Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality.
- Trial name
- NCT01844882
- Volunteers
- 1 people
- Sponsor
- Unity Health Toronto
Real Function Post Conversion From Prograf to Advagraf, Examin Ethnicity and Pharmacogenetics of the Cohort Requiring Dose Adjustment Post-conversion
Renal Function and Pharmacogenetics in Renal Transplant Recipients Converted From Tac BID to Tac OD
In Kidney transplant recipients Once daily Tacrolimus has the poteb]ntial advantage of better adnerence, and perhpas improvement in reanl function compred with the twice daily tacrolimus formulation.
- Trial name
- NCT01884480
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Malabsorption; Carbohydrate, Ileostomy - Stoma
Digestibility of Selected Resistant Starches in Humans
Dietary fiber is a type of carbohydrate which is not digested in the human small intestine. Whole grains are a source of dietary fiber that are used to promote health; however, using whole grains in commercial products results in…
- Trial name
- NCT01939600
- Testing
- Starch-free breakfast, Hi-Maize 260, Hylon VII
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Unity Health Toronto
Mental Health
Coordinated Access to Care From Hospital Emergency Departments
The study will assess the effectiveness and cost-effectiveness of providing brief, intensive case management for frequent users of hospital Emergency Departments who have mental health and/or addictions problems.
- Trial name
- CATCH-ED (NCT01622244)
- Testing
- Co-ordinated Access to Care from Hospital Emergency Departments, Coordinated Access to Care from Hospital Emergency Departments, Counseling and Resource Education
- Where
- 2 sites in Canada
- Volunteers
- 166 people
- Sponsor
- Unity Health Toronto
Pregnancy, Maternal Nutrition
Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant
An overwhelming body of evidence of the protective effect of folic acid supplementation on neural tube defect affected pregnancies led to mandatory folic acid fortification in Canada in 1998.
- Conditions
- Pregnancy, Maternal Nutrition, Fetal Health, Epigenetics
- Trial name
- NCT02244684
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
Standard Versus Accelerated Initiation of Dialysis in Acute Kidney Injury
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared with standard…
- Trial name
- STARRT-AKI (NCT01557361)
- Testing
- Accelerated RRT initiation, Standard RRT initiation
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Dyspnea, Acute Heart Failure
Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department
The purpose of this study is to evaluate a validated diagnostic prediction model in the appropriate diagnosis of Acute Heart Failure (AHF) in patients presenting at the emergency department with undifferentiated dyspnea.
- Conditions
- Dyspnea, Acute Heart Failure, Shortness of Breath
- Trial name
- NCT01193998
- Testing
- Treatment as per model probability, Treatment as per usual care
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 186 people
- Sponsor
- Unity Health Toronto