Clinical trials: sponsored by Unity Health Toronto
Education, General Surgery
Individualized Deliberate Practice on a Virtual Reality Simulator
Training on simulated models in a surgical skills laboratory has been shown to improve technical performance in the operating room.
- Trial name
- NCT01753947
- Testing
- Deliberate Practice
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Ankle Arthritis
Gait Analysis of Ankle Arthroplasty and Arthrodesis
Surgical options for managing hindfoot arthritis include: joint fusion, total ankle joint replacement or osteotomies (realignment) of bones.
- Trial name
- NCT00921076
- Testing
- Gait Analysis
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Stroke, Ischemic Stroke
Clinician JUdgment Versus Risk Score to Predict Stroke outComes: The JURASSIC Clinical Trial
Background: Several risk score models are now available to assist clinicians estimate outcomes after an acute ischemic stroke. Limited information is available on the predictive value of these scores compared to real outcomes and…
- Conditions
- Stroke, Ischemic Stroke, Cerebrovascular Disease
- Trial name
- JURASSIC (NCT01657279)
- Testing
- Clinical scenarios
- Where
- 4 sites in United States, Canada
- Volunteers
- 111 people
- Sponsor
- Unity Health Toronto
Surgical Education
Validation of a Curriculum (STAC) for Technical Skill Acquisition in Minimally Invasive Surgery
This study describes the development and validation of a structured training and assessment curriculum (STAC) for a basic laparoscopic procedure.
- Trial name
- NCT01560494
- Testing
- STAC curriculum
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study
Acute kidney injury (AKI) in the intensive care unit is common, devastating and costly. However, minimal evidence exists to guide the prescription of optimal renal replacement therapy (RRT).
- Trial name
- OMAKI (NCT00675818)
- Testing
- Continuous venvenous hemofiltration (CVVH), Continuous venovenous hemodialysis (CVVHD)
- Where
- 5 sites in Canada
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto
Supratentorial Neoplasms, Aneurysms
Scalp Nerve Blocks for Post-Craniotomy Pain
The objective of this study is to demonstrate that scalp nerve blocks ("scalp freezing"), performed at the end of supratentorial brain surgery, will reduce post-operative pain, opioids side effects, and the time required for…
- Conditions
- Supratentorial Neoplasms, Aneurysms, Arteriovenous Malformation, Epilepsy
- Trial name
- NCT00972790
- Testing
- Bilateral Scalp Nerve Blocks
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Unity Health Toronto
Depression
Cognitive Correlates of Antidepressant Treatment Response in Elders
Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants".
- Trial name
- NCT01477268
- Testing
- Zoloft (antidepressant)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Coronary Artery Disease, Type II Diabetes Mellitus
Innovative Strategies For Risk Reduction Following CABG
Background: Treatment targets for cardiac risk factor reduction are not being met. Therefore, there is a need for new strategies to assist patients in meeting these goals.
- Trial name
- NCT00462436
- Testing
- Consumption of Dietary Portfolio
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Unity Health Toronto
Coronary Artery Bypass Graft Surgery, Spine Surgery
Does Pre-operative Carbohydrate Loading Reduce Insulin Resistance and Improve Outcomes in Elective Surgical Patients?
The recent development of an oral carbohydrate drink for consumption prior to elective surgical procedures has been shown to improve insulin sensitivity.
- Trial name
- Preop (NCT00618592)
- Testing
- PreOp carbohydrate drink
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Patient Discharge, Continuity of Patient Care
Automated Versus Conventional Hospital Discharge Summaries and Prescriptions
The purpose of this study is to determine whether a semi-automated electronic patient discharge summary program leads to increased community physician and housestaff satisfaction and patient outcomes as compared to conventional…
- Conditions
- Patient Discharge, Continuity of Patient Care, Medical Records Systems, Computerized, Hospital Information Systems
- Trial name
- NCT00670865
- Testing
- Electronic discharge summary system
- Where
- Canada
- Volunteers
- 209 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Type 2
Lifestyle Intervention For Effective Diabetes Management
Chronic disease management programs are shown to reduce mortality, recurrent hospitalizations, and improve indirect societal costs among specific subgroups of the population.
- Trial name
- LIFE-DM (NCT00813930)
- Testing
- INTERxVENT lifestyle modification program
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Coronary Disease
A Study to Determine the Effect of Bi-Ventricular Pacing on Cardiac Hemodynamics After Coronary Artery Bypass Graft
The purpose of this study is to determine, using echocardiography, whether bi-ventricular pacing improves the contractile force by resynchronizing both ventricles, thereby improving and/or correcting the paradoxical septal…
- Trial name
- NCT00316368
- Testing
- Ethicon TPW32 60 cm (pacing wires x 2)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Stroke
Effectiveness of Virtual Reality Exercises in STroke Rehabilitation (EVREST)
This study is a pilot, randomized trial that will examine whether the Nintendo Wii virtual gaming system is safe and feasible for use in patients who have had a recent stroke.
- Trial name
- EVREST (NCT00692523)
- Testing
- Recreational therapy activities, Nintendo Wii
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis
Azithromycin in Patients With CF, Infected With Burkholderia Cepacia Complex
Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline in lung function.
- Trial name
- NCT00298922
- Testing
- Azithromycin
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Anemia, Peritoneal Dialysis
Oral Vitamin C for Correction of Anemia in Patients Receiving Peritoneal Dialysis
People with kidney failure are at risk for the development of anemia. Anemia is a decrease in the production of hemoglobin, a substance that carries oxygen in the blood.
- Trial name
- NCT00920413
- Testing
- Vitamin C
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Unity Health Toronto
Respiration, Artificial, Respiratory Insufficiency
24-Hour NAVA Ventilation in Acute Respiratory Failure
Neurally Adjusted Ventilatory Assist (NAVA) is a new mode of mechanical ventilation that is controlled by the electrical activity of the diaphragm (EAdi).
- Trial name
- NCT00583037
- Testing
- Neurally Adjusted Ventilatory Assist (NAVA)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Brain Injuries
Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
This clinical trial will evaluate the ease of conducting a randomized trial on patients with severe head injury who are cared for by paramedics in the out of hospital setting.
- Trial name
- TOPHR HIT (NCT00878631)
- Testing
- hypertonic saline mixed with dextran, Normal Saline
- Where
- 2 sites in Canada
- Volunteers
- 113 people
- Sponsor
- Unity Health Toronto
Post Prandial Blood Glucose
The Effects of Salvia Hispanica-Enriched Foods on Glycemic and Insulinemic Responses and Subjective Satiety
Salvia hispanic (Salba) is postulated to increase satiety. This study determines the optimal amount of Salba as well as whether liquid or solid enriched products will produce maximum satiety.
- Trial name
- NCT00728065
- Testing
- White Bread, White bread with added 7.32g Salvia hispanica, White bread with added 15.58g Salvia hispanica
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Contrast Induced Nephropathy, Critically Ill
N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography
Critically ill patients frequently undergo contrast enhanced computed tomography (CT) to establish diagnoses and direct management. Contrast agents can disturb kidney function and result in kidney dysfunction.
- Trial name
- NCT00830193
- Testing
- N-acetylcysteine
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
The Effect of High Frequency Oscillation on Biological Markers of Lung Injury
Although mechanical ventilation is life saving, it is associated with a number of severe complications collectively referred to as ventilator induced lung injury (VILI).
- Trial name
- NCT00673517
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto