Clinical trials: sponsored by Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia, HHT
CHORUS - Comprehensive HHT Outcomes Registry of the United States (Formerly OUR HHT Registry)
The goal of this study is to better understand HHT, the symptoms and complications it causes ("outcomes") and how the disease impacts people's lives.
- Conditions
- Hereditary Hemorrhagic Telangiectasia, HHT, Arteriovenous Malformation of Brain
- Trial name
- NCT04150822
- Testing
- Registry and Saliva sample
- Where
- Canada
- Volunteers
- 296 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia
Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
This study is one of the three projects of an NIH Rare Disease Clinical Research Consortium. A "consortium" is a group of centres sharing information and resources to perform research.
- Trial name
- BVMC6203 (NCT01158807)
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 2,272 people
- Sponsor
- Unity Health Toronto
type1diabetes
Type 1 Diabetes Virtual Self-management Education and Support
OVERVIEW: People living with type 1 diabetes (T1D) are expected to fit self-management and regular clinical consultations into busy lives.
- Trial name
- T1ME (NCT05756829)
- Testing
- High frequency, low touch virtual health care
- Where
- 9 sites in Canada
- Volunteers
- 580 people
- Sponsor
- Unity Health Toronto
Cardiovascular Disease, Surgical Site Infection
Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients
The goal of this clinical trial is to learn if a new method of closing the breastbone after heart bypass surgery can improve healing and reduce complications in adults undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Cardiovascular Disease, Surgical Site Infection, Superficial Sternal Wound Infection, Mediastinitis
- Trial name
- NCT07507409
- Testing
- Knotless Barbed Sutures, Mesh-based Topical Skin Adhesive
- Volunteers
- 401 people
- Sponsor
- Unity Health Toronto
Neuropathic Pain
Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate new therapies to alleviate pain on neuropathic chronic pain. At this time, the main purpose is to complete a feasibility or pilot study with 30 participants suffering from neuropathic…
- Trial name
- PSYKED-NP (NCT05639322)
- Testing
- Ketamine Hydrochloride, Cognitive Behavioral Therapy, Ketamine + Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Endometriosis, Chronic Pain
Virtual Mindfulness and Endometriosis
Endometriosis is a common gynecologic disease affecting 5-10% of women during their reproductive years.1 Symptoms are variable but can include debilitating pelvic pain, pain with intercourse, menstrual cycles, bowel movements and…
- Trial name
- NCT07501182
- Testing
- 10-week mindfulness course
- Volunteers
- 124 people
- Sponsor
- Unity Health Toronto
Major Depressive Disorder
SMILE Trial - Imaging Sub-Study
This is a pilot sub-study of an ongoing trial comparing N2O to midazolam in MDD and will examine neuroimaging correlates of treatment response.
- Trial name
- NCT05528718
- Testing
- Nitrous oxide gas for inhalation, Midazolam injection
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Appendicitis Acute
First Appendectomy Using Revolve Surgical Robotic Arm
This study is testing a new surgical device called the Revolve Surgical System (RSS) during appendix removal surgery. The RSS is designed to help surgeons perform minimally invasive surgery with improved precision and stability…
- Trial name
- NCT07455487
- Testing
- Revolve Surgical System - RSS
- Volunteers
- 3 people
- Sponsor
- Unity Health Toronto
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Access to Primary Care
Evaluating Novel Approaches That Engage and Support Vulnerable Patient Groups to Equitably Access Primary Care
The goal of this initial clinical trial is to gather information for building a future national trial in Canada that can continuously look at different ways of helping people made vulnerable get a primary care provider.
- Trial name
- ENGAGE (NCT07439627)
- Testing
- Primary care connector
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Suicide
Identifying the Neural Basis of Capability for Suicide
Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system.
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation, Psychiatric Illness
- Trial name
- NCT03327129
- Testing
- fMRI
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Suicide
Pain, Reward, Attention and Neurocircuitry: Biomarkers of Suicidality
The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fMRI and DTI)…
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation
- Trial name
- NCT02811198
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabete Type 2
Effect of a Healthy Food Voucher on Blood Glucose Control in People With Type 2 Diabetes or Prediabetes
This randomized controlled trial (RCT) will determine if access to a voucher for healthy foods reduces blood sugar levels among people living on a low income who have type 2 diabetes or elevated blood sugar.
- Trial name
- VOUCH4DIABETES (NCT05776420)
- Testing
- Food voucher
- Where
- Canada
- Volunteers
- 390 people
- Sponsor
- Unity Health Toronto
HIV Infection, Syphilis Infection
Multiplo Tp/HIV Self-Test
To help reach the undiagnosed living with HIV and/or syphilis in Canada, self-tests for HIV and Syphilis may have substantial utility for increased identification of infected individuals through their relative ease of use and…
- Trial name
- NCT06716450
- Testing
- Multiplo TP/HIV Antibody Test
- Where
- 3 sites in Canada
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
ARDS
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60…
- Trial name
- CAVIARDS (NCT03963622)
- Testing
- Respiratory Mechanics, Standard Ventilation Strategy
- Where
- 33 sites in United States, Argentina and 6 more
- Volunteers
- 740 people
- Sponsor
- Unity Health Toronto
Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee
pDIFFIR: Geriatric Periprosthetic DIstal Femur: FIxation Versus Replacement
Periprosthetic distal femur fractures are a significant source of morbidity and mortality for elderly patients. One treatment option involved a surgical fixation with plates or nails, screws and cables/wires along the side of…
- Conditions
- Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee, Knee Fracture
- Trial name
- pDIFFIR (NCT05805774)
- Testing
- Distal Femur Replacement, Surgical fixation
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- Unity Health Toronto
Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Infrared Light for Memory Loss in Mild Cognitive Impairment (MCI)
Mild cognitive impairment (MCI) is a transitional risk state that occurs between the normal aging process and Alzheimer's dementia (AD).
- Trial name
- PBMCI-Prime (NCT06618807)
- Testing
- Active tPBM device
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Mechanical Ventilation
DIAPHRAGM STRENGTH AND LUNG VOLUMES
Diaphragm dysfunction (loss of diaphragm strength) is common in the intensive care unit (ICU) patients using ventilators. The diaphragm is the main muscle of respiration and its dysfunction can prolong mechanical ventilation and…
- Trial name
- DIAVOLA (NCT07206459)
- Testing
- Healthy Patients, Critically Care Patients
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homelessness, Youth
Transitioning Youth Out of Homelessness 2.5 (TYOH 2.5)
The idea for this study came from the research team's current study called Transitioning Youth Out of Homelessness (TYOH) 2.0, which provides coaching and a leadership guide to youth transitioning out of homelessness.
- Trial name
- NCT06425458
- Testing
- Co-Designed Strengths-Based Leadership Program
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Hypercapnic Respiratory Failure
Asymmetrical High Flow Oxygen Versus Noninvasive Ventilation in Acute Hypercapnic Respiratory Failure
NIV is a life-saving treatment for people with breathing failure and carbon dioxide (CO2) retention. It helps remove this waste gas from the lungs and reduces the effort needed to breathe.
- Trial name
- HIFOLD2 (NCT07157098)
- Testing
- asymmetrical high-flow nasal cannula, non-invasive ventilation with standard mask, non-invasive ventilation with a new mask
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto