Clinical trials: sponsored by Unity Health Toronto
Treatment Resistant Depression, Major Depressive Disorder
Stellate Ganglion Block for Major Depressive Disorder.
This is a feasibility study, to investigate a new treatment option for major depressive disorders by performing a Stellate Ganglion Block (SGB).
- Trial name
- NCT04727229
- Testing
- Bupivacaine Hydrochloride, Normal Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Sudden Cardiac Death, Sudden Cardiac Arrest
Canadian Sudden Cardiac Arrest Network
The overall aim of the project is to develop a national registry to accurately measure the burden of Sudden Cardiac Arrest (SCA) among the general Canadian population.
- Trial name
- C-SCAN (NCT03642587)
- Testing
- There is no intervention in this study.
- Where
- 6 sites in Canada
- Volunteers
- 82,054 people
- Sponsor
- Unity Health Toronto
Operating Room Efficiency
Minimizing Peri-operative Time Delays, Maximizing Operating Room Efficiency: A Pilot Study
The primary objective is to prospectively identify Operating Room (OR) time delays from the time the patient who is undergoing total laparoscopic hysterectomy enters the OR to exiting the OR.
- Trial name
- NCT03257384
- Testing
- Black box recording of surgery
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Vaginal Speculum Examination
Gynaecological Speculum Examination: Straight Horizontal Insertion Versus Vertical Insertion and Rotation.
This study compares two different types of speculum insertion to determine the level of discomfort they might cause. This study compares the straight horizontal insertion (SHI) of the speculum and the vertical insertion and…
- Trial name
- NCT02708615
- Testing
- Type of speculum vaginal insertion method
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Gastric Varices Bleeding, Endoscopic Ultrasound
Primary Prevention of Gastric Varices Bleed
Primary prophylaxis of gastric varices is an important area of research, as gastric varices are a common complication of cirrhosis of the liver.
- Trial name
- NCT05859009
- Testing
- EUS-Guided Therapy of Glue and Coil, Non-Selective Beta Blockers (Propanolol)
- Sponsor
- Unity Health Toronto
Uterine Fibroid
Design of an Intra-operative Blood Conservation Pathway at Open Myomectomy
Uterine fibroids are benign uterine masses that can be removed through a surgical procedure called a myomectomy. Myomectomy is often associated with a significant amount of blood loss for the patient.
- Trial name
- NCT03211481
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Infertility
Access to Infertility Services: Clinic Perspective
Since the identification of the human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS) in the 1980s, there have been significant advances made in the management and long-term prognosis for infected…
- Trial name
- NCT00782132
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pelvic Inflammatory Disease
Rate of Pelvic Inflammatory Disease at St. Michael's Hospital
A retrospective review of women who came through the ER at SMH with a pelvic inflammatory disease (PID) or tubo-ovarian abscess (TOA) between 1995-2005.
- Trial name
- NCT00783419
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Unity Health Toronto
Group B Streptococcus
The Prevalence of Group B Streptococcus Positive Pregnant Patients in an Inner City Tertiary Care Center
A retrospective review of the prevalence of Group B Streptococcus Positive Pregnant Patients in an Inner City Tertiary Care Center
- Trial name
- NCT01251289
- Volunteers
- 628 people
- Sponsor
- Unity Health Toronto
Preterm Labor, Fetal Glucocorticoid Exposure
The Effect of Antenatal Corticosteroids on the Fetal Thymus - a Possible Role in Fetal Immune Programming
Administration of corticosteroids is standard practice for pregnant patients at risk of preterm labour to reduce the risk of neonatal respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and…
- Trial name
- NCT03057717
- Testing
- 2D ultrasound assessment
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Ductus Arteriosus
The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Preterm Birth
Preterm birth still remains a major cause of perinatal morbidity and mortality worldwide. The exact mechanism stimulating term and preterm births in humans is still unknown.
- Trial name
- NCT03073512
- Testing
- Ultrasound examination
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Endometriosis, Chronic Pain
Virtual Mindfulness for the Management of Endometriosis Pelvic Pain.
Endometriosis is a gynecologic condition that can cause severe pelvic pain and significantly impair quality of life. Endometriosis symptoms cannot always be controlled by medical therapy or surgery alone, indicating a need for…
- Trial name
- NCT05554497
- Testing
- Mindfulness-based stress reduction curriculum
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cancer
Incidental Genomics
Health care providers (HCP) are increasingly using genomic sequencing (GS) to diagnose diseases and target treatment for patients. However, GS may incidentally reveal inherited risks for thousands of current and future diseases.
- Trial name
- NCT03597165
- Testing
- Incidental Genomic Sequencing Results, GS Results for Primary Indications only
- Where
- 3 sites in Canada
- Volunteers
- 289 people
- Sponsor
- Unity Health Toronto
Emotional Distress, Quality of Life
At-risk and vulNerable Individuals To Infection With COVID-19 and ProActive inTervention With intEgrated Health and Social Care
This randomized control trial aims to explore a data-driven, proactive approach to identifying patients at greatest risk during the pandemic, and assess the impact of an embedded System Navigator in a primary health care setting.
- Conditions
- Emotional Distress, Quality of Life, Mental Health
- Trial name
- ANTICIPATE (NCT05197608)
- Testing
- System Navigator, Tailored list of resources
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Treatment-resistant Depression (TRD)
Auditory MMN EEG in TRD in Response to Ketamine
To develop and test a neurocomputational model of ketamine treatment response predictions in TRD.
- Trial name
- NCT05464264
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Suicidal Ideation, Suicide
Mitigating Suicide Risk With Single Session 'Brief Skills for Safer Living'
Mental health concerns have been on the rise since the onset of the COVID-19 pandemic. The pandemic has worsened risk factors for suicide, including job loss, anxiety, depression, and loneliness.
- Conditions
- Suicidal Ideation, Suicide, Mental Health Issue, Depression
- Trial name
- NCT04495543
- Testing
- Brief Skills for Safer Living
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- Unity Health Toronto
Alcohol Withdrawal Delirium, Alcohol Withdrawal
Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome
Severe acute alcohol withdrawal syndrome is a potentially life-threatening condition characterized by agitation, confusion, abnormal heart rhythms and seizures.
- Conditions
- Alcohol Withdrawal Delirium, Alcohol Withdrawal, Alcohol Withdrawal Seizures
- Trial name
- PHENOMANAL (NCT03586089)
- Testing
- Phenobarbital Sodium
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia
Topical Anti-angiogenic Therapy for Telangiectasia in HHT: Proof of Concept
Hereditary hemorrhagic telangiectasia (HHT) is a hereditary vascular condition characterized by the development of abnormal connections between arteries and veins throughout the body, called vascular malformations.
- Trial name
- NCT01752049
- Testing
- Topical timolol maleate
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Unity Health Toronto
Depression, Anxiety
Mobile Interventions for the Prevention and Detection of Distress
Stress, anxiety, distress and depression are exceptionally high among healthcare providers at the frontline of the COVID-19 pandemic.
- Conditions
- Depression, Anxiety, Stress, Loneliness
- Trial name
- NCT05072210
- Testing
- Mobile Intervention
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetic Foot Ulcer
A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers
Foot ulcers represent a significant common complication in patients with diabetes. Wound healing is a challenge. Some wounds do not respond to the best practices in wound care.
- Trial name
- NCT00338702
- Testing
- Autologous Platelet Gel
- Where
- Canada
- Sponsor
- Unity Health Toronto