Clinical trials: completed, sponsored by Unity Health Toronto
Syphilis
Evaluation of Enhanced Syphilis Screening Among HIV-positive Men
This study aims to enhance syphilis testing among HIV-positive men who have sex with men (MSM), so that more men will undergo testing, they will test more often, and more cases will be treated early.
- Trial name
- NCT02019043
- Testing
- Syphilis testing with routine HIV bloodwork
- Where
- 4 sites in Canada
- Volunteers
- 3,895 people
- Sponsor
- Unity Health Toronto
HIV
Bone Antiresorptive Therapy With Antiretroviral Initiation (BATARI) Pilot Trial
This is a two-site, three-arm, open-label, pilot randomized controlled trial of bone anti-resorptive therapy during ART initiation in HIV-infected adults.
- Trial name
- BATARI (NCT01968850)
- Testing
- alendronate/vitamin D
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Cancer
Evaluation of a Decision Aid for Incidental Genomic Findings
Health care providers (HCP) are increasingly using genomic sequencing (GS) to target treatment for patients. However, GS may incidentally reveal inherited risks for thousands of current and future diseases.
- Trial name
- NCT03244202
- Testing
- Decision Aid Plus Counselling, Genetic Counselling Only
- Where
- 2 sites in Canada
- Volunteers
- 133 people
- Sponsor
- Unity Health Toronto
Stress, Psychological, Compassion Fatigue
Achieving Resilience in Acute Care Nurses (ARISE).
Nurses are exposed to myriad stressors, both in the workplace and in their everyday lives, which can lead to adverse personal and professional outcomes.
- Trial name
- NCT03017469
- Testing
- ARISE
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Unity Health Toronto
Other Functional Disturbances Following Cardiac Surgery
Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients
Acute and chronic anemia continue to be associated with increased mortality in a number of clinical settings, including cardiac and non-cardiac surgery.
- Trial name
- NCT01883713
- Testing
- Brain Oximetry
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Unity Health Toronto
Elective Cardiac Surgery
Acceptable Range of Inspiratory Effort During Mechanical Ventilation
Partially assisted mechanical ventilation is ideally titrated to maintain adequate inspiratory muscle activity (i.e. preventing disuse atrophy) while avoiding excessive (i.e. fatiguing) inspiratory loads.
- Trial name
- EFFORT (NCT02838524)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
Validation of a Simple Approach to Estimate Alveolar Recruitability in ARDS Patients
This study will test the validity of a new approach to assess alveolar recruitability at the bedside in comparison to direct measurements of lung volume and derecruitment.
- Trial name
- NCT02457741
- Where
- 3 sites in Canada, China and 1 more
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Assessing Diaphragm Muscle Inactivity in Mechanically Ventilated ICU Patients
Background: Mechanical ventilation is a life saving intervention in patients with acute respiratory failure, for instance, due to infection or trauma.
- Trial name
- DIVIP (NCT02434016)
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis
HFN Versus NIV in Cystic Fibrosis. The HIFEN Study
Many patients with cystic fibrosis (CF) require hospitalization and/or Intensive Care Unit (ICU) admission because of acute exacerbation of chronic respiratory failure or for any acute deterioration of clinical status.
- Trial name
- NCT02262871
- Testing
- High flow nasal oxygen cannula, Noninvasive ventilation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Monitoring Intercostal Muscles After Extubation
Mechanical ventilation is a life-saving treatment for critically ill patients who are unable to breathe on their own. At the time of recovery, separation from the ventilator is performed without difficulty for the majority of…
- Trial name
- MIME (NCT02853201)
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Unity Health Toronto
Heart Failure
A Trial of Thiamin Supplementation in Patients With Heart Failure
Background: Patients with heart failure (HF) are at increased risk of developing thiamin deficiency (TD). Thiamin (vitamin B1) is required for the production of energy and therefore TD may contribute to the energy depletion…
- Trial name
- NCT00959075
- Testing
- Vitamin B1
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Colorectal Cancer
Colonoscopic Skill Acquisition and Transfer Via Simulated Curriculum of Progressive Training
It is hypothesized that a progressive simulated learning strategy will result in better global clinical performance (e.g., technical, communication) and transfer of endoscopic skill, as compared with a high-fidelity simulation…
- Trial name
- NCT02000180
- Testing
- Progressive Group
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Patient Educational Materials
Patient Educational Materials for Prostate Cancer Screening
Although the harms of screening for prostate cancer with the prostate-specific antigen (PSA) test outweigh the benefits, 560,000 Ontario men undergo PSA screening each year.
- Trial name
- NCT03222466
- Testing
- Co-created PEM
- Where
- Canada
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Critically Ill
Screening Elderly Patients for Weaning
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- NCT02243449
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Unity Health Toronto
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Kidney Stones
Narrow Versus Wide Focal Zones for Shock Wave Lithotripsy of Renal Calculi
Shockwave lithotripsy (SWL) is a safe, non-invasive treatment for renal calculi. During SWL energy is focused on in order to break kidney stones and this energy can be varied in size from a narrow (or small) focal zone to a wide…
- Trial name
- NCT01226875
- Testing
- SWL: Shock Wave Lithotripsy Intervention
- Where
- 3 sites in Canada
- Volunteers
- 275 people
- Sponsor
- Unity Health Toronto
Sex Steroids
Effect of Pregnancy on Androgenic Steroids in Different Genetic Panels
Androgens are important sex steroids in women. Androgens influence protein synthesis and muscle growth, are involved in maturation of the reproductive organs, have a fat reducing effect , have a negative effect on the serum lipid…
- Trial name
- NCT03064412
- Testing
- Urine sample collection, Saliva collection
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Obesity
Obesity Heterogeneity Study
The investigators will assess the heterogeneity of obese individuals in the United States to help researchers, clinicians and policymakers to establish goals for obesity treatment and identify whether differing interventions may…
- Trial name
- NCT03155880
- Volunteers
- 1,685 people
- Sponsor
- Unity Health Toronto
Endoscopy Simulation
Impact of a Simulation-based Training Curriculum of Non-technical Skills on Colonoscopy Performance
The investigators aim to test a curriculum of non-technical skills (NTS) training for simulation-based training of colonoscopy. There is no known literature to date on the optimal approach on how to teach NTS in endoscopy.
- Trial name
- NCT02877420
- Testing
- Non-Technical Skills Training Curriculum, Conventional Simulation Training Group
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto