Clinical trials: completed, sponsored by Unity Health Toronto
End-stage Renal Disease, Left Ventricular Hypertrophy
In-Centre Nocturnal Hemodialysis (INHD): A Long-Term Follow-Up Study
Background: In 2010, approximately 39000 Canadians had end-stage renal disease (ESRD), and the prevalence rate of dialysis has increased by 189% over the past 2 decades.
- Trial name
- INHD (NCT02684773)
- Testing
- Conventional Hemodialysis, In-centre Nocturnal Hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency, Ventilator-Induced Lung Injury
APRV/BIPAP With Spontaneous Breathing on Lung Protection
Mechanical ventilation (MV) is a cornerstone of management of acute respiratory failure, but MV per se can provoke ventilator-induced lung injury (VILI), especially in acute respiratory distress syndrome (ARDS).
- Trial name
- APRV/BIPAP (NCT02071277)
- Testing
- Pressure targeted modes
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
HIV Positive Pregnant Women
Positive Pregnancy Program
The Positive Pregnancy Program is an innovative, unique, interprofessional model of care for HIV-positive pregnant women. This program has been in place at St. Michael's Hospital for five years.
- Trial name
- P3 (NCT03073421)
- Testing
- Qualitative interview
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Hypertension, Blood Pressure
Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation
Ginseng has been used for many years in a wide array of anecdotal medicinal properties. Animal and limited clinical research points to the vascular effects of Korean Red Ginseng (KRG).
- Conditions
- Hypertension, Blood Pressure, Endothelial Function
- Trial name
- ESGC (NCT00728221)
- Testing
- Korean Red Ginseng, Korean Red Ginseng (Panax ginseng), Cornstarch
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hepatopulmonary Syndrome
A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome
The hepatopulmonary syndrome (HPS)and pre-HPS is a disease seen in patients with chronic liver disease, whereby patients develop dilations in the blood vessels of the lungs, resulting in low oxygen levels and shortness of breath.
- Trial name
- NCT00362752
- Testing
- Norfloxacin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
Acute Myocardial Infarction
Ticagrelor for PCI Post Thrombolysis
Ticagrelor is a first line therapy along with aspirin for patients undergoing primary PCI for STEMI. However, many patients are still treated with fibrinolytic therapy and the safety and efficacy of Ticagrelor has not been…
- Trial name
- SETFAST (NCT01930591)
- Testing
- Ticagrelor, Clopidogrel
- Where
- 5 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
HIV, Human Immunodeficiency Virus
PRe-Exposure Prophylaxis Acceptability & Readiness Assessments for Toronto gaY, Bisexual and Other Men Who Have Sex With Men-5
Canada continues to see an unrelenting stream of new HIV diagnoses, with a disproportionate burden among gay, bisexual, and other MSM in major centers such as Toronto.
- Trial name
- PREP-5 (NCT02149888)
- Testing
- Tenofovir/emtricitabine
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Early Detection of Cancer, Cancer
Comparing Methods of Recall for Cancer Screening in Primary Care: a Pragmatic Clinical Trial
This randomized trial aims to understand how effective a reminder letter is compared to a reminder phone call in improving breast, cervical and colorectal cancer screening rates and reducing screening disparities.
- Conditions
- Early Detection of Cancer, Cancer, Socioeconomic Status
- Trial name
- NCT02457143
- Testing
- Letter, Phone call
- Where
- Canada
- Volunteers
- 5,270 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Overweight
Effectiveness and Safety of Salba on Weight Loss in Overweight Individuals With Type 2 Diabetes
Canadian statistics indicate that the incidence of obesity is increasing and that the occurrence of diabetes in obese individuals is 5-fold greater than those with a healthy weight, making weight control in this population…
- Conditions
- Diabetes Mellitus, Overweight, Obesity
- Trial name
- LOSS (NCT01403571)
- Testing
- Salba (Salvia hispanica L.), Oat-based Control
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type II Diabetes Control
Effect of Ginseng in Type 2 Diabetes
Objective: We aim to evaluate longer term efficacy and safety of AG as an add-on therapy in patients with type 2 diabetes controlled by conventional treatment.
- Trial name
- NCT02923453
- Testing
- CNT 2000 American ginseng extract
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Unity Health Toronto
Diabetes
A Computer-Based Simulation of DKA Management
A 2-by-2 factorial cluster randomized controlled trial was performed to: 1) Compare the effects of supervised (coached) versus unsupervised (no coach) administration of the DKA simulator on trainees' knowledge of DKA management…
- Trial name
- DKA (NCT02799563)
- Testing
- Coach, Preselected number of cases, Coach, Self-selected number of cases, No coach, Preselected number of cases
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Agitation
Treating Acutely Agitated Patients With Asenapine Sublingual Tablets
Our proposal is to administer asenapine to patients who are clinically agitated and in need of immediate intervention. At present there are no controlled studies that we know of that explores the use of asenapine for this…
- Trial name
- NCT01400113
- Testing
- Asenapine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Blood Pressure
Effect of Ginseng on Blood Pressure
To determine the effect of ginseng on blood pressure control.
- Trial name
- NCT01913210
- Testing
- Ginseng
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Epiretinal Membrane
Topical Use of Corticosteroid to Prevent Epiretinal Membrane Following Retinal Tear
In this prospective randomized controlled double blind pilot clinical study, we aim to assess whether administration of a topical corticosteroid would attenuate epiretinal membrane formation following development of retinal tears…
- Trial name
- NCT02412059
- Testing
- Prednisolone acetate
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Heart Failure
Evaluating Teach Back as a Method for Improving Self-Care Behaviours in Heart Failure Patients
Patient education using Teach Back has the potential to increase self-care behaviour in heart failure (HF) patients and reduce adverse clinical outcomes.
- Trial name
- NCT01311583
- Testing
- Teach Back method of patient discharge teaching
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
TBI (Traumatic Brain Injury), Acute Brain Injuries
Study of Cerebral Tissue Oxygenation During Transfusion in Traumatic Brain Injury
This proposal aims to provide some objective, non-invasively achieved, physiologically relevant data in order to provide some rational basis for decision-making for transfusion in sTBI.
- Trial name
- NIRSTBI (NCT01728831)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Hyperglycemia, Postprandial
Effect of Salba & Flax on Postprandial Glycemia and Subjective Satiety
The purpose of this study is to determine whether drinks containing Salvia hispanica L (Salba) or Flax lower postprandial blood glucose levels and improve appetite in healthy individuals.
- Trial name
- NCT02621307
- Testing
- Salba, Flax, Control
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Postoperative Nausea and Vomiting
Study of Prevention of Postoperative Nausea and Vomiting Using Cesamet
Untreated, one third of patients undergoing general anesthesia will have postoperative nausea, vomiting, or both. Patients often rate postoperative nausea and vomiting (PONV) as worse than postoperative pain.
- Trial name
- Cesamet (NCT02115529)
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 331 people
- Sponsor
- Unity Health Toronto
Screening for Partner Violence
Computer-assisted Screening for Intimate Partner Violence in Family Practice
This study tested the effectiveness of computer-assisted screening for identifying patients at risk of intimate partner violence (IPV) in a Canadian family practice.
- Trial name
- NCT00385034
- Testing
- Interactive computer based health-risk survey before doctor's visit
- Where
- Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Education, Simulation
Developing a Curriculum to Teach Laparoscopic Colorectal Surgery
Although a significant amount of work has been done to validate simulators as viable systems to teach technical skills outside the operating room, the next necessary step is to integrate simulator training into a comprehensive…
- Conditions
- Education, Simulation, Technical Skills Training, Laparoscopy
- Trial name
- NCT01371136
- Testing
- curricular training
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto