Clinical trials: completed, sponsored by Unity Health Toronto
Obesity
Design and Validation of a Simulation-based Training Curriculum for Laparoscopic Bariatric Surgery
Laparoscopic bariatric surgery is an advanced laparoscopic procedure with a potential for significant morbidity and mortality along the early part of a surgeon's learning curve.
- Trial name
- NCT01610466
- Testing
- Laparoscopic bariatric surgery ex-vivo training curriculum
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Education, Laparoscopic Surgery
Comprehensive Laparoscopic Curriculum for Medical Students
Laparoscopic surgery has become the standard approach to a vast variety of surgical procedures. Due factors such as 2D- to 3D conversion, reduced tactile sensation, amplification of tremor and fulcrum effect of the abdominal…
- Trial name
- NCT01857180
- Testing
- Curriculum
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Crisis Resource Management
Peer Debriefing Versus Instructor Debriefing for Interprofessional Simulation Based Education
Crisis management is important for operating room practice and non-technical skills are acknowledged as key to ensure patient safety in these situations.
- Trial name
- PICS (NCT01067378)
- Testing
- Peer-led debriefing, Expert instructor debriefing
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Ischemic Stroke
Efficacy of Virtual Reality Exercises in STroke Rehabilitation: A Multicentre Study (EVREST Multicentre)
A multicentre, randomized, two parallel group study comparing virtual reality using Wii gaming technology versus Recreational activities in patients receiving conventional rehabilitation after an ischemic stroke.
- Trial name
- NCT01406912
- Testing
- Recreational Activity, Wii Gaming System Arm
- Where
- 13 sites in Argentina, Brazil and 3 more
- Volunteers
- 141 people
- Sponsor
- Unity Health Toronto
End-stage Renal Disease, Left Ventricular Hypertrophy
Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease
Background: Recent data indicate that home nocturnal hemodialysis (8 hours of hemodialysis at home for 5-6 nights per week) may have substantial cardiovascular benefits, including regression of left ventricular (LV) hypertrophy…
- Trial name
- NCT00718848
- Testing
- Incentre nocturnal hemodialysis, Remaining on conventional hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Hypertension
The Evaluation and Standardization of Ginseng and Its Components for Blood Pressure Regulation
While the use of herbals is increasing considerably, their efficacy and safety in the humans remains largely unknown. This surge in demand prompts a call for its evaluation.
- Trial name
- NCT00730951
- Testing
- Korean Red Ginseng, Corn Starch
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Cardiac Surgery
Transfusion Triggers in Cardiac Surgery
A high proportion of patients having cardiac surgery receive red cell transfusions. Yet, the investigators do not know whether transfusions are beneficial and they may be associated with harm.
- Trial name
- TTRICS (NCT00470444)
- Testing
- Transfusion with Red Blood Cells, 1 unit of donated red blood cells
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Pulmonary Hypertension
Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery.
- Trial name
- NCT00334490
- Testing
- Sildenafil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
End-stage Renal Disease
Two phosphAte taRGets in End-stage Renal Disease Trial (TARGET)
Patients with end-stage renal disease (ESRD) who have elevated serum phosphate (P) levels have significantly higher mortality rates compared to those with normal P.
- Trial name
- TARGET (NCT01994733)
- Testing
- Calcium carbonate ( Intensive phosphate control), Calcium carbonate (Liberalized phosphate control)
- Where
- 5 sites in Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Cardiac Arrest
The Strategies for Post Arrest Resuscitation and Care Network
Background: One of the 2010 Impact Goals of the Emergency Cardiac Care (ECC) Committee of the American Heart Association is to double survival from cardiac arrest.
- Trial name
- SPARC (NCT00683683)
- Testing
- Knowledge Translation
- Volunteers
- 32 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
A Diaphragmatic Electrical Activity Based Optimization Strategy During Pressure Support Ventilation
Pressure support (PS) is a commonly used mode of ventilation which is triggered based upon the patient's own inspiratory efforts. For the most part, pressure support is well tolerated by patients.
- Trial name
- NCT02067403
- Testing
- Pressure-support Eadi optimization
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Unity Health Toronto
Surgical Technical Skill, Technical Errors in Surgery
Comprehensive Surgical Coaching
Simulation in surgical skills training is widely accepted as a necessary step to improve surgical training outside the operating room. Simulation predominately focuses on teaching a specific task or procedure.
- Trial name
- NCT01875679
- Testing
- Comprehensive Surgical Coaching, Conventional Surgical Training
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cystic Fibrosis, Vitamin D Deficiency
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients
The main aim of the research question to test the primary hypothesis of this study, namely, Does 12 weeks of an additional 5000 IU daily of cholecalciferol increase serum 25OHD levels in adults with Cystic Fibrosis (CF) who have…
- Trial name
- NCT00685971
- Testing
- 5000 IU of cholecalciferol
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Chronic Kidney Disease
The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis
Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality.
- Trial name
- NCT01844882
- Volunteers
- 1 people
- Sponsor
- Unity Health Toronto
Real Function Post Conversion From Prograf to Advagraf, Examin Ethnicity and Pharmacogenetics of the Cohort Requiring Dose Adjustment Post-conversion
Renal Function and Pharmacogenetics in Renal Transplant Recipients Converted From Tac BID to Tac OD
In Kidney transplant recipients Once daily Tacrolimus has the poteb]ntial advantage of better adnerence, and perhpas improvement in reanl function compred with the twice daily tacrolimus formulation.
- Trial name
- NCT01884480
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Malabsorption; Carbohydrate, Ileostomy - Stoma
Digestibility of Selected Resistant Starches in Humans
Dietary fiber is a type of carbohydrate which is not digested in the human small intestine. Whole grains are a source of dietary fiber that are used to promote health; however, using whole grains in commercial products results in…
- Trial name
- NCT01939600
- Testing
- Starch-free breakfast, Hi-Maize 260, Hylon VII
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Unity Health Toronto
Mental Health
Coordinated Access to Care From Hospital Emergency Departments
The study will assess the effectiveness and cost-effectiveness of providing brief, intensive case management for frequent users of hospital Emergency Departments who have mental health and/or addictions problems.
- Trial name
- CATCH-ED (NCT01622244)
- Testing
- Co-ordinated Access to Care from Hospital Emergency Departments, Coordinated Access to Care from Hospital Emergency Departments, Counseling and Resource Education
- Where
- 2 sites in Canada
- Volunteers
- 166 people
- Sponsor
- Unity Health Toronto
Pregnancy, Maternal Nutrition
Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant
An overwhelming body of evidence of the protective effect of folic acid supplementation on neural tube defect affected pregnancies led to mandatory folic acid fortification in Canada in 1998.
- Conditions
- Pregnancy, Maternal Nutrition, Fetal Health, Epigenetics
- Trial name
- NCT02244684
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
Standard Versus Accelerated Initiation of Dialysis in Acute Kidney Injury
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared with standard…
- Trial name
- STARRT-AKI (NCT01557361)
- Testing
- Accelerated RRT initiation, Standard RRT initiation
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Dyspnea, Acute Heart Failure
Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department
The purpose of this study is to evaluate a validated diagnostic prediction model in the appropriate diagnosis of Acute Heart Failure (AHF) in patients presenting at the emergency department with undifferentiated dyspnea.
- Conditions
- Dyspnea, Acute Heart Failure, Shortness of Breath
- Trial name
- NCT01193998
- Testing
- Treatment as per model probability, Treatment as per usual care
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 186 people
- Sponsor
- Unity Health Toronto