Clinical trials: completed, sponsored by Unity Health Toronto
Evaluation Studies, Implementation Research
Implementation of the Begin Exploring Fertility Options, Risks and Expectations (BEFORE) Decision Aid
The Begin Exploring Fertility Options, Risks and Expectations (BEFORE) decision aid was created to support fertility discussions and decision-making for young breast cancer patients in Canada.
- Conditions
- Evaluation Studies, Implementation Research, Decision Aid, Young Adult Cancer
- Trial name
- BEFORE (NCT03629509)
- Testing
- Educational Webinar and Resources
- Where
- Canada
- Volunteers
- 116 people
- Sponsor
- Unity Health Toronto
Chronic Obstructive Pulmonary Disease (COPD), Smoking Cessation
Personalized Smoking Cessation Infographic in COPD
This study assesses the effect of a personalized smoking cessation infographic on physician smoking cessation counseling rates and smoking cessation pharmacotherapy prescription rates.
- Trial name
- NCT04119934
- Testing
- Smoking Cessation Intervention Tool
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia, Nosebleeds
Sirolimus for Nosebleeds in HHT
This pilot study is to determine the safety and efficacy of oral sirolimus (blood trough level 6-10ng/ml) in patients with HHT that are experiencing moderate or severe epistaxis.
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Nosebleeds, Epistaxis
- Trial name
- NCT05269849
- Testing
- Sirolimus
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Wellness, Burnout, Caregiver
Evaluating the Impact of Resource Navigators to Support LTC and RH Staff During and Beyond COVID-19
The goal of this clinical trial is to test how well resource navigators help long-term care and retirement home staff access the various health and wellness resources available to them and the effects that this has on their…
- Conditions
- Wellness, Burnout, Caregiver, Burnout, Professional, COVID-19
- Trial name
- NCT05677997
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homelessness, Youth
Transitioning Youth Out of Homelessness 2.0 (TYOH 2.0)
Introduction: This 12-month pilot randomized controlled trial (RCT) built on previous community-engaged work and explored whether portable rent subsidies and an intervention targeting identity capital (purpose, control…
- Trial name
- NCT05781503
- Testing
- Identity Capital Intervention (Coach + Co-designed Leadership Guide), Monthly Rent Subsidies
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homeless Persons, Case Management
Navigator Program for Homeless Adults
Individuals experiencing homelessness often have complex health and social needs. This population also faces disproportionate systemic barriers to accessing health care services and social supports, such as not having primary…
- Conditions
- Homeless Persons, Case Management, Primary Care, Hospital Readmission
- Trial name
- NCT04961762
- Testing
- Navigator Program
- Where
- Canada
- Volunteers
- 656 people
- Sponsor
- Unity Health Toronto
Social Determinants of Health, Healthcare Disparities
Social Equity Data in Primary Care: How Best to Collect Data From Hard-to-Reach Populations
The goal of this clinical trial is to learn whether a community-based outreach approach can improve the collection of social and demographic information in adult primary care patients who may be harder to reach through standard…
- Conditions
- Social Determinants of Health, Healthcare Disparities, Primary Health Care, Health Equity
- Trial name
- NCT07550101
- Testing
- Community health surveyor
- Where
- Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia
Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
This study is one of the three projects of an NIH Rare Disease Clinical Research Consortium. A "consortium" is a group of centres sharing information and resources to perform research.
- Trial name
- BVMC6203 (NCT01158807)
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 2,272 people
- Sponsor
- Unity Health Toronto
Neuropathic Pain
Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate new therapies to alleviate pain on neuropathic chronic pain. At this time, the main purpose is to complete a feasibility or pilot study with 30 participants suffering from neuropathic…
- Trial name
- PSYKED-NP (NCT05639322)
- Testing
- Ketamine Hydrochloride, Cognitive Behavioral Therapy, Ketamine + Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Major Depressive Disorder
SMILE Trial - Imaging Sub-Study
This is a pilot sub-study of an ongoing trial comparing N2O to midazolam in MDD and will examine neuroimaging correlates of treatment response.
- Trial name
- NCT05528718
- Testing
- Nitrous oxide gas for inhalation, Midazolam injection
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Suicide
Pain, Reward, Attention and Neurocircuitry: Biomarkers of Suicidality
The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fMRI and DTI)…
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation
- Trial name
- NCT02811198
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Homelessness, Youth
Transitioning Youth Out of Homelessness 2.5 (TYOH 2.5)
The idea for this study came from the research team's current study called Transitioning Youth Out of Homelessness (TYOH) 2.0, which provides coaching and a leadership guide to youth transitioning out of homelessness.
- Trial name
- NCT06425458
- Testing
- Co-Designed Strengths-Based Leadership Program
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Coronary Artery Bypass Graft Surgery, Atherosclerosis
Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery
The purpose of this study is to determine if evolocumab added to regular statin therapy improves vein graft patency after coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion
- Trial name
- NEWTON-CABG (NCT03900026)
- Testing
- Evolocumab
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 782 people
- Sponsor
- Unity Health Toronto
MCI, Amnestic Mild Cognitive Disorder
Neuro RX Gamma for Amnestic Mild Cognitive Impairment (aMCI)
Over 50 million people worldwide are currently living with dementia-a number projected to rise to 152 million by 2050. Mitochondrial dysfunction in the brains of individuals with Mild Cognitive Impairment (MCI) and Alzheimer's…
- Trial name
- NCT05563298
- Testing
- Neuro RX Gamma device
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
ARDS, Human
Screening Expiratory Flow Limitation by Flow-time Curve
Expiratory flow limitation (EFL) is defined as a dynamic condition that expiratory flow cannot be further increased with higher expiratory driving pressure.
- Trial name
- FLOWLY (NCT03215316)
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
HIV Testing, HIV Infections
OraQuick® HIV Self-Test Study in Canada
Oral fluid based HIV Self-testing (HIVST) provides another innovative and simple option to increase opportunities for HIV testing.
- Trial name
- OQHIVST (NCT05020353)
- Testing
- OraQuick® HIV Self-Test
- Where
- 7 sites in Canada
- Volunteers
- 951 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Stress, Trauma
STEP: Building Trauma Resilience Among Nurses and Personal Support Workers During and Beyond COVID-19
The COVID-19 pandemic has amplified the need for skills training and mental health support for healthcare workers who are exposed to the numerous stressors and potential trauma of a high-risk environment.
- Conditions
- Stress, Trauma, Mental Health Issue, Healthcare Workers
- Trial name
- NCT04682561
- Testing
- Supportive Trauma Exposure Preparation Program
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia (HHT)
Doxycycline for Hereditary Hemorrhagic Telangiectasia
This study will investigate the effectiveness of oral doxycycline for the treatment of recurrent nasal hemorrhage in Hereditary Hemorrhagic Telangiectasia (HHT) subjects.
- Trial name
- HHT (NCT03397004)
- Testing
- Doxycycline Hyclate
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia, Epistaxis Nosebleed
Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT)
This study will investigate the effectiveness of oral low-dose tacrolimus for the treatment of recurrent nasal hemorrhage in HHT subjects.
- Trial name
- NCT04646356
- Testing
- Tacrolimus capsule (low-dose)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto