Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Rheumatoid Arthritis
Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-guided Dose Reduction in Patients With Rheumatoid Arthritis
The goal of this open label multicenter randomized controlled pragmatic superiority trial is to investigate the optimal treatment/tapering strategy with rituximab for patients with rheumatoid arthritis.
- Trial name
- RITUXERA (NCT06003283)
- Testing
- Rituximab
- Where
- 7 sites in Belgium
- Volunteers
- 134 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Constipation
Effect to Linaclotide on Colonic Motility
This study aim was to evaluate the effect of Linaclotide, a pharmacological treatment normally used to treat functional constipation or irritable bowel syndrome with predominant constipation, on colonic motility as assessed by…
- Trial name
- NCT06989268
- Testing
- Linaclotide 290 micrograms
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pelvic Abscess, Adnexal Cyst
Ultrasound-guided Transvaginal Aspiration of Cystic Pelvic Lesions
Adnexal cysts or pseudocysts are a common finding on transvaginal ultrasound, especially in premenopausal women. Due to the size of some cysts, they may cause discomfort.
- Conditions
- Pelvic Abscess, Adnexal Cyst, Ovarian Neoplasms
- Trial name
- UTAC (NCT06988280)
- Testing
- Ultrasound-guided transvaginal aspiration of cystic pelvic lesions.
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rheumatoid Arthritis
App-based Education and GOal-setting in Rheumatoid Arthritis
The purpose of this pragmatic, investigator-initiated, multicentre randomised controlled trial is to study the effectiveness and feasibility of a mobile app-based self-management intervention for patients with rheumatoid…
- Trial name
- AEGORA (NCT05888181)
- Testing
- Mobile app-based self-management intervention
- Where
- 2 sites in Belgium
- Volunteers
- 128 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBD (Inflammatory Bowel Disease)
Enhancing Endoscopic Scoring Consistency and Accuracy in IBD: a Video-based Training Approach
Endoscopic scoring systems are vital for the objective assessment of disease activity being used in both clinical trials and daily clinical practice.
- Trial name
- CONCORDIA (NCT06961942)
- Testing
- Training
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Meningioma, Pituitary Disease
The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction
In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.
- Conditions
- Meningioma, Pituitary Disease, Pituitary Adenoma, Craniopharyngioma
- Trial name
- Endo-Olfact (NCT06874426)
- Testing
- Endoscopic endonasal skull base surgery
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 154 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Drug-Related Side Effects and Adverse Reactions
Effect of a trAnSitional Pharmacist Intervention in geRiatric Inpatients on Hospitals Visits After dischargE
A randomized controlled trial will be performed in geriatric inpatients to investigate the impact of a multifaceted clinical pharmacy intervention on health related outcomes.
- Trial name
- ASPIRE (NCT04617340)
- Testing
- Multifaceted clinical pharmacy intervention
- Where
- Belgium
- Volunteers
- 827 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spastic Cerebral Palsy (sCP), Acquired Brain Injury
Impact of AFOs on the GMF of Children With CP or ABI
Children with cerebral palsy (CP) or an acquired brain injury (ABI) are often prescribed ankle-foot orthoses (AFOs) to correct impairments of muscles and/or to prevent contractures and bony deformities.
- Trial name
- NCT06930963
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coxarthrosis, Avascular Necrosis of Hip
Effect of Peri-operative Glucocorticoids on Short-term Functional Outcome After THA
This randomized, single surgeon, placebo controlled, double blind study will be conducted in order to investigate whether or not peri-operative high doses of intravenous glucocorticoids improve short-term functional outcome after…
- Trial name
- DEXA (NCT04317872)
- Testing
- High dose of peri-operative intravenous dexamethasone, Low dose of peri-operative intravenous dexamethasone
- Where
- Belgium
- Volunteers
- 71 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Femoroacetabular Impingement
Investigating the Reliability of Highly Dynamic 3D Motion Analysis Protocol in Adolescence and Adult Males
Femoroacetabular impingement is an orthopedic condition that is primarily characterized by the presence of anatomic bony abnormalities in the femoral head and/or the acetabulum resulting in an abnormal contact between the two…
- Trial name
- CAM-FAI relia (NCT04822571)
- Testing
- Reliability of 3D motion analysis protocol
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Femoro Acetabular Impingement, CAM
Longitudinal Follow-up of Male Soccer Players Prone to Developing CAM Hip Deformity
Femoroacetabular impingement (FAI) is a clinical problem in which abnormal contact occurs between the thighbone and the hip socket.
- Trial name
- CAM-FAI (NCT04418596)
- Testing
- bi-planer radiography (EOS), Conventional radiography (Hip+pelvis)
- Where
- Belgium
- Volunteers
- 27 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Aspergillosis; Pulmonary, Invasive (Etiology)
Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients
The objective of this study is to deliver proof of concept that antifungal prophylaxis can reduce the incidence of Influenza Associated Aspergillosis (IAA) in ICU (intensive care unit) patients with severe influenza.
- Trial name
- POSA-FLU (NCT03378479)
- Testing
- SOC +Posaconazole 18 MG/ML (milligram/milliliter), standard of care (SOC)
- Where
- 12 sites in Belgium, France and 1 more
- Volunteers
- 88 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Congenital Heart Disease, Neurodevelopmental Disorders
Predictive Value of Neurovascular Coupling in Infants With COngenital Heart Disease
Infants with congenital heart disease (CHD) are at increased risk for delayed neurodevelopment. Multiple etiological explanations have been proposed, as there seems to be a multifactorial interplay of both prenatal and…
- Conditions
- Congenital Heart Disease, Neurodevelopmental Disorders, Electroencephalography, Near-Infrared Spectroscopy
- Trial name
- NICO (NCT06190210)
- Testing
- electroencephalography, Near-Infrared Spectroscopy, neuronal cell-free DNA
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glioma of Brain
Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients
Gliomas are the most common primary intracranial tumors, representing at least 75% of all primary malignant brain tumors. Histopathologically, gliomas are classified into different subgroups including astrocytomas (60-70%)…
- Trial name
- Glioma2015 (NCT03849430)
- Where
- Belgium
- Volunteers
- 750 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Polymyalgia Rheumatica
Validation of the PMR Activity Score and Evolution of Patient-reported Outcomes in Patients With Polymyalgia Rheumatica
Polymyalgia rheumatica (PMR) is a systemic inflammatory disease that affects elderly people. It is characterized by pain and morning stiffness in the shoulders, pelvic girdles and neck.
- Trial name
- NCT05542316
- Where
- Belgium
- Volunteers
- 133 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prostate Cancer, Radiotherapy
Observational Study on Extreme Hypofractionation for Localized Prostate Cancer
Radiotherapy (RT) is an established treatment option for localized prostate cancer (PCa), with cure rates similar to those of radical prostatectomy.
- Conditions
- Prostate Cancer, Radiotherapy, SBRT
- Trial name
- OBELIX PCa (NCT05344235)
- Testing
- SBRT
- Where
- Belgium
- Volunteers
- 246 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
A Study to Evaluate Non-invasive Measurements of the Inflammatory Status in Patients with IBD
Patients with IBD, including both Crohn's disease and ulcerative colitis, require accurate monitoring of intestinal inflammation for optimal follow-up and treatment.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- VERSATILE (NCT06900738)
- Testing
- Inflammometer
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tooth, Impacted
Effect of Interceptive Strategies on the Clinical Outcome of Maxillary Impacted Canines
This study aims to investigate the effect of 3 randomly applied interceptive measures (slow maxillary expansion, extraction of deciduous canines and no intervention) on maxillary canine impaction in patients with early mixed…
- Trial name
- NCT05629312
- Testing
- Maxillary expansion, Extraction of deciduous upper canines
- Where
- Belgium
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Weight Regain Post Bariatric Surgery, Obesity (Disorder)
Naltrexone/Bupropion With or Without Very Low Calorie Ketogenic Diet for Weight Regain After Bariatric Surgery
The goal of this clinical trial is to evaluate the superiority of combined VLCKD, intensive lifestyle intervention and naltrexone/bupropion (N/B) versus standard of care with naltrexone/bupropion on weight loss for people with…
- Trial name
- Relay (NCT06881485)
- Testing
- Very Low Calorie Diet
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Visual Impairment
A Computerized, Adaptive Therapeutic Gaming Approach Training Visual Perceptual Skills in Children With CVI
This clinical trial aims to compare the effectiveness of our adaptive, therapeutic game to the effectiveness of the same game, without the adaptive component.
- Trial name
- iVision2_WP3 (NCT05014503)
- Testing
- Adaptive Therapeutic gaming, Non-adaptive Therapeutic gaming
- Where
- Belgium
- Volunteers
- 73 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven