Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Liver Metastases, Colorectal Cancer
Chemoembolisation With CPT11 Loaded DC Bead With Cetuximab and 5FU/LV in First Line in Patients With KRAS Wildtype mCRC
The purpose of this study is to assess feasibility of chemoembolization with DC Bead loaded with Irinotecan in combination with Cetuximab and 5FU/LV as a first line treatment for wildtype KRAS unresectable liver metastases from…
- Trial name
- NCT01631539
- Testing
- DC Bead™, Cetuximab, 5 FU
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Orthodontics, Malocclusion
The Use of 2D and 3D Imaging Modalities and Its Influence on Diagnosis and Treatment Planning in Orthodontics
Research questions: 1. Will the panoramic images derived from cone beam CT data give better diagnostic ability than conventional panoramic radiographs? 2.
- Conditions
- Orthodontics, Malocclusion, Impacted Tooth, Cephalometry
- Trial name
- NCT01246830
- Testing
- Panoramic radiograph, Cephalometric radiograph, Cone-beam computed tomography (CBCT)
- Where
- 2 sites in Belgium
- Volunteers
- 32 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sedentary Lifestyle
A stAPP to a Healthier Lifestyle
The main objective of the project is to make participants aware of their sedentary behavior (prolonged sitting behavior) and then to encourage behavioral change through the use of an innovative and fun application on a smartphone.
- Trial name
- NCT01975870
- Testing
- Application on smartphone
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cachexia
Development of a Screening Tool to Detect and Stage Cachectic Cancer Patients
The aim of the study is to develop a screenings tool that will enable hospital nurses to detect and stage cancer cachectic patients.
- Trial name
- NCT01533909
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Exploration of How Patients Deal With Side Effects From Chemotherapy
A Qualitative Study Into How Patients Deal With Chemotherapy-related Side Effects at Home
This qualitative study explores how patients deal with the side effects from chemotherapy at their home, what factors and ideas influence their symptom self-management and how professional caregivers contribute to the management…
- Trial name
- NCT01867489
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthmatic Patients
Development and Validation of a Sputum Biomarker mRNA Panel for the Diagnostic Work-up of Asthma 3
The main objectives of the study are: 1. To unravel the importance of molecular phenotyping in predicting the response to classical anti-asthma treatment (leukotriene antagonists) The investigators have developed a non-invasive…
- Trial name
- BioSput-Air (NCT01224964)
- Testing
- Montelukast, long acting beta2 mimetic
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prevalence of Augmented Renal Clearance, Risk Factors for Augmented Renal Clearance
Augmented Renal Clearance in the Adult Non-critically Ill Surgery Patient: a Prospective Point Prevalance Study
This point prevalence study investigates the prevalence of augmented renal clearance (i.e. a measured 8-hour urinary creatinine clearance >= 120 ml/min/1.73m²) in an adult non-critically ill abdominal and trauma surgery…
- Trial name
- ARCPPS (NCT02228551)
- Testing
- Augmented renal clearance Point prevalence study
- Where
- Belgium
- Volunteers
- 279 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Elderly
Objective Assessment and Promotion of Physical Activity in Elderly
The purpose of the present study is to evaluate the short-term and long-term effects of a cycle ergometer program on physical activity and physical fitness in elderly (65+).
- Trial name
- NCT01748461
- Testing
- Structured intervention, Coach intervention
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
Digital 3D Breast Tomosynthesis Versus 2D in Clinical Evaluation of High Risk Women
Patients with a higher breast cancer risk (higher than 17% according to the IBIS calculation) will receive a 2D digital mammography together with a 3D tomosynthesis (so called combo tomo) of both breasts in two views in order to…
- Trial name
- NCT02209129
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy
Evidence-based Physical Therapy in Children With Cerebral Palsy
The study aims to evaluate evidence-based practice behavior in usual care physical therapy in Flanders. Secondly, it aims to compare the effectiveness of a predefined physical therapy program based on evidence-based guidelines to…
- Trial name
- NCT02193386
- Testing
- No intervention, no follow-up, only registration, Intervention period
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Post Cystostomy
Oral Nutrition After Regular Radical Cystectomy
After radical cystectomy, postoperative ileus (POI) is a common complication resulting in a delayed oral nutritional intake with prolonged recovery and hospital stay.
- Trial name
- ONP (NCT01777126)
- Testing
- Oral Nutrition Protocol (ONP) group, Control group
- Where
- Belgium
- Volunteers
- 94 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Intestinal Manipulation
Study on the Effect of Surgical Intestinal Manipulation
The aim of this study is to study the impact of brain death and surgical small bowel manipulation on the release of different types of monocytes.
- Trial name
- IMMO (NCT02189512)
- Testing
- blood sampling
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Polycystic Liver Disease
Lanreotide Autogel in the Treatment of Symptomatic Polycystic Liver Disease
An open-label, Phase II clinical study to evaluate the efficacy and safety of lanreotide autogel 90mg every 4 weeks in the treatment of symptomatic polycystic liver disease, including a dose escalation at month 6 to lanreotide…
- Trial name
- LOCKCYST (NCT01315795)
- Testing
- Lanreotide Autogel 90 mg and 120 mg
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Invasive Pulmonary Aspergillosis
Evaluation of Exhaled Breath Condensate in the Diagnosis of Invasive Pulmonary Aspergillosis
The purpose of this study is to evaluate the diagnostic potential of biomarkers for invasive pulmonary aspergillosis in exhaled breath condensate.
- Trial name
- NCT01247142
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neurofibromatosis Type 1
Ophthalmological Screening and Follow-up of Optic Pathway Gliomas in Children With Neurofibromatosis Type 1.
The goal of this project is to get more insight into the (neuro)ophthalmological characteristics of children with neurofibromatosis type 1.
- Trial name
- NCT02078401
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Iatrogenic Disease
Rationalisation of Polypharmacy by the Geriatric Consultation Team
Polypharmacy is a common problem in elderly, leading among others to increased adverse drug events. The aim of this pilot study was to evaluate whether a systematic medication evaluation by a geriatric consultation team using the…
- Trial name
- RASP-GCT (NCT02165618)
- Testing
- Medication review, based on but not limited to the RASP list
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Heart Failure
Feasibility of Pharmaceutical Interventions in Elderly Heart Failure Patients.
Heart failure therapies (e.g. beta blockers) have been successful in decreasing mortality rates, as well as diminishing hospitalizations.
- Trial name
- RASP-HF (NCT02149940)
- Testing
- heart-failure related pharmaceutical intervention
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hepatitis B, Hepatitis B, Chronic
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity
In this project proposal, the investigators will investigate the genetic alterations of Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage liver disease.
- Conditions
- Hepatitis B, Hepatitis B, Chronic, End Stage Liver Disease, Carcinoma, Hepatocellular
- Trial name
- NCT02148562
- Where
- Belgium
- Volunteers
- 274 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
Rationalisation of Polypharmacy in the Elderly by the RASP Instrument
The aim of this study is to determine whether a clinical pharmacist using the RASP list (RASP = Rationalisation of home medication by an adjusted STOPP-list in older patients; STOPP = Screening Tool of Older Persons' potentially…
- Trial name
- RASP (NCT01513265)
- Testing
- Pharmaceutical care plan, mostly based on the RASP
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Myocardial Infarction
Effects of Nitric Oxide for Inhalation in Myocardial Infarction Size
The purpose of this study is to determine the effects of Nitric Oxide for Inhalation on Myocardial Infarction Size.
- Trial name
- NOMI (NCT01398384)
- Testing
- Nitric Oxide, MI size at 48-72 hours
- Where
- 4 sites in Belgium, Hungary and 1 more
- Volunteers
- 250 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven