Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Morphine, Morphine Adverse Reaction
Side Effects of a Single Shot Intrathecal Morphine in Clinical Practice, a Retrospective Analysis
ITM has the potential to be a powerful tool for multimodal postoperative pain management, understanding, preventing and managing its side effects is crucial for upturn of patient safety and comfort.
- Conditions
- Morphine, Morphine Adverse Reaction, Morphine Induced Pruritis, Nausea and Vomiting, Postoperative
- Trial name
- NCT07238179
- Testing
- Intrathecal Morphine
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lumbar Radiculopathy, Radicular Low Back Pain
R³ Rehab Pathway Versus Usual Care After Lumbar Radicular Surgery
The R³ trial is a multicentre cluster randomized controlled trial evaluating an evidence-based, person-centred rehabilitation pathway for patients undergoing lumbar surgery for radicular pain.
- Trial name
- R³ (NCT07313566)
- Testing
- R³ Rehabilitation Pathway
- Where
- 16 sites in Belgium
- Volunteers
- 480 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dialysis; Complications
Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Serum Magnesium Levels
Individuals with ESKD and treated with hemodialysis have a high mortality risk. Associative studies suggest a relationship between serum magnesium concentration and mortality risk.
- Trial name
- OMAGOD-1 (NCT07565779)
- Testing
- A - Dialysate magnesium 0.75, B - Dialysate magnesium 1.00 mmol/L
- Where
- 4 sites in Belgium
- Volunteers
- 54 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Perennial Allergic Rhinitis, Seasonal Allergic Rhinitis
The Role of the Nasal Allergen Provocation Test in Starting and Monitoring Allergen Immunotherapy
This prospective multicentric academic NAPT study aims to compile a database of all patients who initiate immunotherapy. The NAPT will take place before, during and after AIT to evaluate the cost and effectiveness of the…
- Conditions
- Perennial Allergic Rhinitis, Seasonal Allergic Rhinitis, Local Allergic Rhinitis
- Trial name
- NCT04544774
- Testing
- AIT, NAPT
- Where
- 2 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Rhinosinusitis (Diagnosis)
Xylitol vs Saline Nasal Irrigations in CF-CRS
Cystic fibrosis (CF) is the most common genetic disorder in Belgium, affecting 1 in 2850 children. A defect in the CFTR channel results in increased viscosity of extracellular secretions and decreased mucociliary clearance in the…
- Trial name
- NCT05531630
- Testing
- Nasal rinsing with saline 0.9%, Nasal rinsing with Xylitol
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Heart Defects, Congenital, Pulmonary Arterial Hypertension
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions
Pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is associated with considerable morbidity and even mortality.
- Conditions
- Heart Defects, Congenital, Pulmonary Arterial Hypertension, Genetic Testing
- Trial name
- NCT02691689
- Testing
- Genetic testing
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronavirus Infections
In-depth Immunological Investigation of COVID-19.
The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors…
- Trial name
- COntAGIouS (NCT04327570)
- Testing
- Patient sampling
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ventricular Tachycardia (VT)
Cardiac RadiothErapy for VEntricular Tachycardia II
Steoreotactic therapy radioablation has become a standard of care option for patients with therapy-refractory ventricular tachycardia, yet long-term outcome is lacking.
- Trial name
- CREVET II (NCT06744530)
- Testing
- stereotactic radiotherapy ablation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke, Spasticity
Pilot Study on Muscle, Tendon, and Neural Changes Post-Botulinum Toxin Injections in Post-stroke Spastic Equinovarus
Poststroke spasticity significantly impairs function, particularly through the development of pes equinovarus. Botulinum toxin A (BoNT) injections into the medial gastrocnemius (MG) are a first-line treatment.
- Conditions
- Stroke, Spasticity, Equinovarus Foot
- Trial name
- NCT06767631
- Testing
- threedimensional freehand ultrasound and instrumented spasticity assessment
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spastic Cerebral Palsy (sCP)
Botulinum Neurotoxin for Children With CP: a Delicate Balance Between Clinical Benefits and Muscular Harm
A cross-sectional design study will be carried out to explore the morphological muscle properties and alterations in muscle composition on a macroscopic level in children with spastic cerebral palsy (CP).
- Trial name
- Bo-Balance (NCT06991725)
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Radicular Pain, Lumbar Surgery
Return to Work After Lumbar Surgery: a Nationwide Survey of Spinal Surgeons' Practices
This national cross-sectional survey investigates the current practices and perceptions of Belgian spinal surgeons regarding return to work (RTW) after lumbar surgery for radicular pain.
- Conditions
- Radicular Pain, Lumbar Surgery, Radicular Pain Related to Lumbosacral Disc Disease, Fusion of Spine, Lumbar Region
- Trial name
- NCT07193758
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Autism, Autism Spectrum Disorder
Promoting Emotional and Autonomic Control Through Guided Breathing Exercises for Emerging Adults With Autism
This study examines the impact of guided breathing exercises on stress and heart rate variability (HRV) in autistic young adults.
- Trial name
- PEACE-A (NCT07238153)
- Testing
- Guided breathing exercise - SPB, Guided breathing exercise - HRV-BF
- Where
- 2 sites in Belgium
- Volunteers
- 68 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Comparing XEN®-63 Gel Stent and PRESERFLO® MicroShunt
The goal of this randomized controlled clinical trial is to learn whether two minimally invasive bleb-forming glaucoma implants can effectively treat adult patients with open-angle glaucoma who require surgical lowering of…
- Trial name
- MINI-BATTLE (NCT07359547)
- Testing
- XEN®-63 Gel Stent, PRESERFLO™ MicroShunt
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 166 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Conductive Hearing Loss
Wideband Tympanometry as a Non-behavioral Test of the Speech-weighted Middle Ear Transfer Function.
There is a need for a non-behavioral clinical test that provides an assessment of how speech is conducted through the middle ear for the optimization of middle ear implants.
- Trial name
- NCT07557771
- Testing
- Wideband Tympanometry
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Edentulous; Alveolar Process, Atrophy
Lateral Sinus Floor Elevation in Implant Therapy.
The L-PRF block is a combination of bone substitute with L-PRF. The use of a L-PRF block in bone augmentation therapies could enhance and improve bone regeneration.
- Trial name
- NCT03495700
- Testing
- L-PRF block, DBBM
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fever of Unknown Origin, IgG4 Related Disease
The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA.
The aim of the study to evaluate the performance of new [18F]-AlF-FAPI-74 PET/CT in three inflammatory disorders (fever of unknown origin, IgG4-related disease and axial spondyloarthritis) and compare with the current…
- Conditions
- Fever of Unknown Origin, IgG4 Related Disease, Axial Spondylarthritis (axSpA), Inflammation of Unknown Origin
- Trial name
- NCT07535554
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Left Ventricular Dyssynchrony, Heart Failure
AMEND-CRT: Mechanical Dyssynchrony as Selection Criterion for CRT
Previous experience with cardiac resynchronization therapy (CRT) candidates suggests that selection of these patients can be improved.
- Conditions
- Left Ventricular Dyssynchrony, Heart Failure, Cardiomyopathy, Dilated, Cardiac Remodeling, Ventricular
- Trial name
- AMEND-CRT (NCT04225520)
- Testing
- Cardiac resynchronization therapy ON, Cardiac resynchronization therapy OFF
- Where
- 24 sites in Belgium, Brazil and 9 more
- Volunteers
- 500 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis
Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders
The goal of this study is to use ultra-high-resolution (UHR) PET imaging to better understand how the brain and spinal cord change in healthy aging and in neurological and psychiatric disorders such as Alzheimer's disease (AD)…
- Conditions
- Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis, Parkinson s Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- NCT07509125
- Testing
- UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoarthritis of Shoulder
Glenohumeral Joint Contract Patterns in Osteoarthritic Glenoids
Shoulder osteoarthritis (OA) is a frequent problem in our aging population and is believed to occur in up to 20% of the population.
- Trial name
- TSA (NCT06154694)
- Testing
- Stereo Radiographic EOS Measurements
- Where
- Belgium
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Triple Negative Breast Neoplasms
Bicalutamide and Abemaciclib in Inoperable or Metastatic Androgen Receptor-positive Triple-negative Breast Cancer
This study has as goal to evaluate the use of abemaciclib and bicalutamide in androgen receptor positive metastatic triple negative breast cancer.
- Trial name
- ABBICAR (NCT06365788)
- Testing
- Abemaciclib, Bicalutamide
- Where
- 6 sites in Belgium
- Volunteers
- 53 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven