Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Irritable Bowel Syndrome
Dose-dependent FODMAP Reintroduction in IBS
The aim of this study is to evaluate whether symptom recurrence, after successful FODMAP elimination, is dose-dependent in patients with IBS.
- Trial name
- DORI (NCT05808023)
- Testing
- FODMAP powder reintroduction
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Cancer
Perioperative Zanidatamab and Chemotherapy for HER2 Positive Gastroesophageal Cancer
The HER-OIC clinical trial is a Phase 1b/2a study investigating a new combination of treatments for patients with HER2-positive gastroesophageal cancer.
- Trial name
- HER-OIC (NCT07477444)
- Testing
- Zanidatamab Combined with Chemotherapy
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Irritable Bowel Syndrome
Efficacy of the DOMINO Diet App in IBS
The aim of this study is to evaluate whether the DOMINO diet application is an effective tool in the treatment of Irritable bowel syndrome in tertiary care.
- Trial name
- EDDI (NCT05808036)
- Testing
- Dietary intervention: DOMINO app, Dietary intervention: low FODMAP diet
- Where
- Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Intra-bony Pockets, Periodontitis
Biologicals in Management of Intra-Bony Defects
The aim is of this study is to evaluate and compare the effects (clinical and radiological) of different biomaterials on the repair of bone defects around the teeth.
- Trial name
- NCT07292870
- Testing
- Minimally invasive surgical treatment of the intra-bony defects, Use of the xenograft Bio-Oss® Collagen during the surgery, Use of enamel matrix derivative (Emdogain®)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prosthetic Joint Infection, Hip Prosthesis Infection
Long Term Follow-up of Patients With Prosthetic Joint Infection of the Hip Treated at University Hospitals Leuven
Prosthetic Joint Infection (PJI) of a Total Hip Replacement (THR) is a disastrous complication of an otherwise extremely successful surgical procedure.
- Trial name
- PROFITH (NCT05000723)
- Testing
- Standard of care
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Soft Tissue Sarcoma, Bone Sarcoma
Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients
Primary bone and soft tissue sarcomas are an exceptionally rare form of cancer, collectively accounting for only 1% of all malignancies diagnosed.
- Trial name
- QOLSarcoma (NCT05051059)
- Testing
- Functional outcome, Health related quality of life (HRQoL) assessment
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions.
- Trial name
- Micronerves (NCT06142929)
- Testing
- Microfasciectomy
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Femoroacetabular Impingement
Biomechanical Investigation of Symptomatic FAI and Two Groups of Asymptomatic Controls
Femoroacetabular impingement (FAI) is an orthopaedic condition that is primarily characterized by the presence of anatomic bony abnormalities in the femoral head and/or the acetabulum resulting in an abnormal contact between the…
- Trial name
- CAM-FAI adult (NCT06272292)
- Testing
- EOS, 3D motion lab analysis
- Where
- Belgium
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Disease
Ultrasound Features of Dupuytren's Disease
Dupuytren's disease (DD) is a benign and progressive condition that affects the palmar aponeurosis with a very high global incidence.
- Trial name
- Micro in DD (NCT06956027)
- Testing
- Ultrasound assesment, ROM measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Deformity
Multimodal Bio-mechanical Analysis of Adult Spinal Deformity With Sagittal Plane Misalignment
A good understanding of the principles of balance is vital to achieve optimal outcomes when treating spinal disorders. A complex interaction of the neuromotor system and muscular recruitment is necessary for ergonomic balance and…
- Trial name
- ASD (NCT04812730)
- Testing
- 2D versus 3D analysis of EOS stereo radiographic analysis, Static versus dynamic analysis, Pre- versus postoperative analysis
- Where
- Belgium
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ankle and Hindfoot Alterations
3D Multisegment Foot Model Used for the Clinical Outcome After Ankle and Hindfoot Reconstruction
Most symptomatic pathologies of the ankle and hindfoot are determined by biomechanical alterations of this anatomical region. Surgical treatment of these pathologies is therefore aimed at improving the inferior biomechanical…
- Trial name
- 3D-MFM (NCT04822558)
- Testing
- Plantar pressure measurement, Gait analysis, Ankle and hindfoot reconstruction surgery
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Primary Total Knee Arthroplasty
Journey Bicruciate Stabilized (BCS) Design and Legion Posterior Stabilized (PS) Design; Comparative Study
Today, primary total knee arthroplasty (TKA) is considered to be a safe and successful therapy for end-stage osteoarthritis of the knee.
- Trial name
- BCR (NCT04855864)
- Testing
- Follow-up of BCR TKA, Follow-up of BCS TKA, Follow-up of PS TKA
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy Volunteers
An Analysis of Healthy Caucasian Knees
In current literature, databases of healthy knee anatomy and function are confined to small sample sizes or singular imaging modalities.
- Trial name
- PC-CT KNEE (NCT07470671)
- Testing
- CT scan images of the knee, EOS scan of full leg, Ultrasound-based gap analysis
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cartilage Damage, Knee Injuries
Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant
The goal of this study is to evaluate the efficacy, safety and performance of the Episealer® device in a sample size of 30 patients and on the long term (10 years follow-up).
- Trial name
- Episealer2 (NCT03755388)
- Testing
- Episealer
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Deformity
Balance Assessment Scale and Strength Measurement Protocol to Measure Functionality in Adults With Spinal Deformity
Develop reliable methods for functional assessment, for trunk strength, of Adult Spinal Deformity (ASD) patients and create a first clinical and normative database 1. Compare functionality of ASD and control subjects 2.
- Trial name
- F-ASD (NCT04642456)
- Testing
- Trunk strength measurement, EOS stereoradiographic full body exam
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Knee Arthropathy, Return to Work
Determinants for Return to Work After Primary Knee Arthroplasty
The increase of end-stage osteoarthritis (OA) in an increasingly younger population is directly correlated with the rising incidence of obesity.
- Trial name
- RTW (NCT04665180)
- Testing
- Primary knee arthroplasty
- Where
- Belgium
- Volunteers
- 88 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adolescent Idiopathic Scoliosis
3D, Dynamic and Mechanically-informed Decision Making in AIS
Adolescent Idiopathic Scoliosis (AIS) is a growth defect of the spine that primarily occurs in prepubertal children between the age of 10 to 14 years, affecting approximately 3% of these otherwise normal children.
- Trial name
- 3D-AIS (NCT04761549)
- Testing
- Adolescent Idiopathic Scoliosis
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Palmaris Longus Muscle and Dupuytren
Dupuytren disease is a medical condition characterized by the painless formation of nodules in the palm of the hand. Cords are formed on the palmar fascia, a connective tissue sheet in the palm of the hand.
- Trial name
- Palmaris (NCT06281509)
- Testing
- Non-invasive tests to determine the presence or absence of the palmaris longus tendon in both hands., Ultrasound
- Where
- Belgium
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Cirrhosis, Viral Pneumonia
Liver Cirrhosis Patients With Invasive Pulmonary Aspergillosis: in Depth Understanding Clinical Host Risk Factors
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection of the respiratory system, caused by a specific fungus called Aspergillus species.
- Conditions
- Liver Cirrhosis, Viral Pneumonia, Fungal Infection, Invasive Pulmonary Aspergillosis
- Trial name
- LIVERIPA (NCT07238114)
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cow's Milk Protein Allergy
Post-failure Stepwise Heat-Denaturated Protein Introduction for Tolerance Induction in Cow's Milk Allergy Observational Cohort Study
Subjects who failed to become tolerant within 12 months after randomization within one of the three arms in the TEHITI study, can participate in the post-TEHITI observational trial to study the natural tolerance induction process.
- Trial name
- Post-TEHITI (NCT07448740)
- Where
- 5 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven