Clinical trials: sponsored by University College, London
Spinal Cord Injuries, Neurogenic Bladder
Dorsal Genital Nerve Stimulation for Bladder Management After SCI
Following spinal cord injury signals between the brain and the bladder are disrupted. As a result the bladder often becomes overactive which can lead to the need for frequent trips to the toilet, regular incontinence episodes and…
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Neurogenic Detrusor Overactivity, Neurogenic Bladder Dysfunction
- Trial name
- NEUROMOD UCon (NCT05502614)
- Testing
- Neuromodulation
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Vascular Diseases
Quantitative Perfusion Imaging Using Contrast Enhanced Perfusion Ultrasound, MRI and Perfusion Angiography
Peripheral Arterial Disease is the narrowing and blocking of the blood vessels that supply the legs and feet. It is a common and progressive condition that affects patients of all backgrounds and genders and is more common in…
- Trial name
- QPiPAD (NCT06103708)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University College, London
Ovarian Cancer, Relapsed Ovarian Cancer
Adaptive ChemoTherapy for Ovarian Cancer in Patients With Replased Platinum-sensitive High Grade Serous or High Grade Endometrioid Ovarian Cancer
ACTOv will compare standard 3-weekly carboplatin (AUC5), to carboplatin delivered according to an AT regimen. The AT regimen will modify carboplatin dose according to changes in the clinical-standard serum biomarker CA125 as a…
- Conditions
- Ovarian Cancer, Relapsed Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- ACTOv (NCT05080556)
- Testing
- Carboplatin
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Parkinson's Hallucinations, Dementia With Lewy Bodies
Trial of Ondansetron as a Parkinson's HAllucinations Treatment
TOPHAT (Trial of Ondansetron as a Parkinson's HAllucinations Treatment) is a double blind, individually randomized, placebo-controlled, parallel group, flexible dose trial of ondansetron (8-24mg/day) as a treatment for…
- Trial name
- TOP HAT (NCT04167813)
- Where
- 23 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University College, London
Recurrent Glioblastoma
Reirradiation and Niraparib in Patients With Recurrent Glioblastoma
The goal of this clinical trial is to investigate a drug called niraparib in patients with glioblastoma that was previously treated but has returned (called recurrent glioblastoma, or rGBM).
- Trial name
- RiNG (NCT05666349)
- Testing
- Niraparib, Re-irradiation (re-RT)
- Sponsor
- University College, London
Sarcopenia, Chronic Lung Disease
Feasibility of Proteomics in Chronic Lung Disease With Sarcopenia
Sarcopenia, the loss of muscle mass and strength with ageing, is a prevalent condition in older adults, particularly those with chronic lung diseases like COPD and interstitial lung disease.
- Trial name
- NCT06312774
- Testing
- This is observational study
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University College, London
Mitochondrial Diseases, Blepharoptosis
Red Light Ptosis Proof-of-Concept
This study tests a new treatment to help with droopy eyelids (ptosis) and eye movement problems (squint) in children and young people with genetically confirmed mitochondrial conditions - using red-light.
- Trial name
- NCT06292182
- Testing
- Near-infrared light
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Psychogenic Nonepileptic Seizures, Dissociative Seizures
ADIE-FS - Aligning Dimensions of Interoceptive Experience in Patients With Functional Seizures
Functional seizures are common and harmful. They look like epileptic seizures but are not caused by the excess electrical discharges in the brain that arise in epilepsy.
- Conditions
- Psychogenic Nonepileptic Seizures, Dissociative Seizures, Psychogenic Pseudoseizure, Functional Neurological Disorder
- Trial name
- ADIE-FS (NCT06105996)
- Testing
- Interoceptive training
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Prostate Cancer
Exploiting Risk-Based Risk Stratification in Early Prostate Cancer to Discriminate Progressors From Non-Progressors
This study seeks to analyse MRI images and biological samples from 60 men diagnosed as having intermediate risk prostate cancer at baseline and one year afterwards to compare the molecular, genetic and transcriptomic differences…
- Trial name
- RECONCILE (NCT04340245)
- Testing
- NA (Observational)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Alveolar Bone Resorption, Alveolar Ridge Trauma
Vertical Ridge Augmentation Strategies
Guided Bone Regeneration (GBR) is an invaluable and beneficial surgical technique adopted when there is the need to augment an alveolar atrophy.
- Conditions
- Alveolar Bone Resorption, Alveolar Ridge Trauma, Alveolar Bone Loss, Complication of Surgical Procedure
- Trial name
- VARGAS (NCT06242782)
- Testing
- VRA + d-PTFE membrane, VRA + e-PTFE membrane, VRA + customised Ti-mesh
- Volunteers
- 148 people
- Sponsor
- University College, London
Sedentary, Overweight
The Efficacy of Chlorella Supplementation on Health and Performance Following a 12-week Training Programme
Algae are an emerging functional food source that are gaining traction and popularity in biopharmaceutical, nutraceutical, and biotechnology industries.
- Trial name
- NCT05639634
- Testing
- Chlorella supplementation, 12 week cardiovascular training programme
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University College, London
Retinitis Pigmentosa
Coloured-light in Retinitis Pigmentosa.
This study will assess the effect of 2 different colours of light on colour vision in adults with retinitis pigments (RP). Participants will be 18 years or above with a genetically confirmed molecular diagnosis of RP.
- Trial name
- CLIRP (NCT06224114)
- Testing
- Coloured-light torch, Different coloured-light torch
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Post-traumatic Stress Disorder
Feasibility of an Intervention for Somatic Flashbacks in PTSD
This trial will explore the feasibility and acceptability of an intervention for Somatic flashbacks in Post-Traumatic Stress Disorder (PTSD). Imagery Rescripting (ImRs) will form a central part of the intervention.
- Trial name
- NCT05996913
- Testing
- Imagery rescripting
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University College, London
Primary Aldosteronism
Short- and Long-term Outcomes of Adrenalectomy for Primary Aldosteronism
The proposed study is this. Short- and long-term outcomes of adrenalectomy for Primary Aldosteronism (PA) in a single centre. PA is a relatively common problem and considers as the commonest cause of secondary hypertension and…
- Trial name
- NCT06192810
- Testing
- Laparoscopic/open adrenalectomy
- Volunteers
- 84 people
- Sponsor
- University College London Hospitals
Duchenne Muscular Dystrophy
Outcome Measures in Duchenne Muscular Dystrophy: A Natural History Study
Novel emerging therapies for Duchenne Muscular Dystrophy (DMD) require a deeper understanding of DMD natural history. This study aim to assess the natural history of DMD through a composite assessment tool capable of capturing…
- Trial name
- NCT02780492
- Testing
- Set of assessment tools
- Where
- 5 sites in France, Netherlands and 1 more
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University College, London
Head and Neck Cancer
High Dose vs Low Dose I 131 +/- rhTSH for Differentiated Thyroid Cancer
RATIONALE: Radioactive iodine uses radiation to kill tumor cells. Giving iodine I 131 with or without thyroid-stimulating hormone after surgery may kill any tumor cells that remain after surgery.
- Trial name
- HiLo (NCT00415233)
- Testing
- recombinant thyroid-stimulating hormone, Radiodine ablation without rhTSH
- Where
- 25 sites in United Kingdom
- Volunteers
- 438 people
- Sponsor
- University College, London
Hodgkin Lymphoma
Avelumab in the Frontline Treatment of Advanced Classical Hodgkin Lymphoma - a Window Study
This is a phase II, non-randomised, multicentre study to assess the safety and efficacy of the PD-L1 inhibitor, avelumab, in a previously untreated fit population of high risk stage II, stage III and stage IV classical Hodgkin…
- Trial name
- AVENuE (NCT03617666)
- Testing
- Avelumab
- Where
- 11 sites in Australia, United Kingdom
- Volunteers
- 49 people
- Sponsor
- University College, London
Bladder Cancer
Detecting Bladder Cancer Using the UroMark Test.
DETECT I is a prospective multicentre observational diagnostic study to assess the performance of the UroMark assay to rule out bladder cancer in patients with haematuria.
- Trial name
- DETECT I (NCT02676180)
- Testing
- Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 3,700 people
- Sponsor
- University College, London
Bronchial and Thymic Neuroendocrine Tumour, Paraganglioma/ Phaeochromocytoma
Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications
This study is a phase 2, open, single-site trial. The primary objective of this study is to prospectively evaluate the safety and efficacy in participants treated with Lu-177 DOTATATE (Lutathera) in unresectable or metastatic…
- Conditions
- Bronchial and Thymic Neuroendocrine Tumour, Paraganglioma/ Phaeochromocytoma, Medullary Thyroid Carcinoma, Those Requiring Repeat Peptide Receptor Radionuclide Therapy
- Trial name
- NCT06121271
- Testing
- Lu-177 DOTATATE (Lutathera®)
- Volunteers
- 110 people
- Sponsor
- University College, London
Congenital Disorders
Study of Late-foetal Human Organ Development
Knowledge about abnormal organ development is important to understand pathology and to develop novel treatment approaches for individuals with congenital and acquired disease.
- Trial name
- NCT04661059
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University College London Hospitals