Clinical trials: sponsored by University College, London
Bladder Cancer
To Detect the Sensitivity of the UroMark Assay
This is a prospective multicentre observational study to assess the sensitivity of the UroMark assay to detect bladder cancer in participants with new or recurrent disease.
- Trial name
- DETECT II (NCT02781428)
- Where
- 19 sites in United Kingdom
- Volunteers
- 1,643 people
- Sponsor
- University College, London
Dementia
SOcial coNNEction in Long-Term Care Home Residents
This study aims to develop a new measure which can accurately assess social connection for people with dementia living in long-term care homes.
- Trial name
- SONNET (NCT05315960)
- Where
- 2 sites in Canada, United Kingdom
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University College, London
Lymphoma
PET Scan in Planning Treatment in Patients Undergoing Combination Chemotherapy For Stage IA or Stage IIA Hodgkin Lymphoma
RATIONALE: A PET scan may help doctors learn how the cancer responded to combination chemotherapy and whether radiation therapy is also required.
- Trial name
- RAPID (NCT00943423)
- Testing
- Involved Field Radiotherapy, No further treatment
- Where
- United Kingdom
- Volunteers
- 602 people
- Sponsor
- University College, London
Pituitary Adenoma
Intraoperative Ultrasound in Patients Undergoing Transsphenoidal Surgery for Pituitary Adenoma
Pituitary adenoma can be difficult to cure with approximately a third of patients in contemporary series' undergoing incomplete resection.
- Trial name
- NCT03284775
- Testing
- Intraoperative ultrasound
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University College, London
Hodgkin Lymphoma
Response Adapted Incorporation of Tislelizumab Into the Front-line Treatment of Older Patients With Hodgkin lYmphoma
The goal of this clinical trial is to test the effect of tislelizumab treatment in patients with Hodgkin lymphoma. The main question it aims to answer is whether including a drug called tislelizumab in first-line treatment of…
- Trial name
- RATiFY (NCT05627115)
- Testing
- Tislelizumab, AVD, Radiotherapy
- Volunteers
- 80 people
- Sponsor
- University College, London
Coronary Heart Disease
Effect of Remote Ischemic Preconditioning in Patient Undergoing Cardiac Bypass Surgery
During coronary artery bypass graft surgery, injury occurs to the heart muscle. Some of this injury is due to the deprivation of oxygen and nutrients to the heart (a process called ischemia) during the surgery itself.
- Trial name
- NCT00397163
- Testing
- Remote ischemic preconditioning
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College London Hospitals
Bronchopulmonary Dysplasia, Neonatal Disease
The Baby Lung Study
The introduction of exogenous surfactant therapy has significantly improved the mortality in preterm infants born between 23- and 28-weeks of gestation.
- Trial name
- NCT05152316
- Testing
- Observational study
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- University College, London
Inflammation, Periodontal Diseases
Mechanisms of Acute Inflammation Following Periodontal Treatment
Periodontitis (gum disease) is a chronic inflammatory disease linked to a imbalance of oral microbiome. The most usual treatment involves removal of sub and supra-gingival plaque and calculus otherwise known as Non-surgical…
- Trial name
- MANTRA (NCT05178563)
- Testing
- IPT+PDT
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College, London
Non-small Cell Lung Cancer
Deciphering Afatinib Response and Resistance With INtratumour Heterogeneity
To assess if targeting activating EGFR and HER2 mutations in Non-Small Cell Lung Cancer (NSCLC) is more effective when these mutations are truncal dominant mutations (≥50%), as opposed to non-dominant (≥5 to <50%) or low…
- Trial name
- DARWIN1 (NCT02183883)
- Testing
- Afatinib
- Where
- 7 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Neuromuscular Diseases
The Bridges Self-management Programme for People With Neuromuscular Diseases
Objectives: To evaluate the feasibility of delivering the Neuromuscular Bridges Self-Management Programme (NM Bridges) in addition to usual care.
- Trial name
- ADAPT-NMD (NCT05460156)
- Testing
- Bridges Self-management Support
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- University College London Hospitals
Distal Hereditary Motor Neuropathy, Type II, Distal Hereditary Motor Neuropathy, Type V
Muscle Structure, Function and Gait in dHMN
Distal Hereditary Motor Neuropathy (dHMN) is a rare inherited neuromuscular disorder. It is characterised by distal weakness. The condition usually manifests in the second decade of life and progresses slowly.
- Conditions
- Distal Hereditary Motor Neuropathy, Type II, Distal Hereditary Motor Neuropathy, Type V, Distal Hereditary Motor Neuronopathy Type I, Distal Hereditary Motor Neuronopathy Type VI
- Trial name
- GAIT-dHMN (NCT04193228)
- Testing
- Carbon Fibre Ankle Foot Orthosis, Exercise
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Prostate Cancer
Radiotherapy and Androgen Deprivation In Combination After Local Surgery (RADICALS) Translational Study
The goal of this translational study is to test the use of biomarkers in salvage treatment for prostate cancer after a previous operation to remove the prostate.
- Trial name
- RADICALS-TR (NCT06145958)
- Testing
- Luteinising Hormone-Releasing Factor Analogue
- Volunteers
- 2,585 people
- Sponsor
- University College, London
Spontaneous Bacterial Peritonitis
Primary Antibiotic Prophylaxis Using Co-trimoxazole to Prevent Spontaneous Bacterial Peritonitis in Cirrhosis
A multicentre, interventional, double-blind, placebo-controlled, parallel-arm, phase 3, randomised controlled trial to evaluate the use of co-trimoxazole as primary prophylaxis for spontaneous bacterial peritonitis to improve…
- Trial name
- ASEPTIC (NCT04395365)
- Testing
- Co-Trimoxazole 960Mg Dispersible Tablet
- Where
- United Kingdom
- Volunteers
- 442 people
- Sponsor
- University College, London
Glioma
[18F] FDOPA PET Imaging in Glioma: Feasibility Study for PET Guided Brain Biopsy
[18F]fluorodopa (3, 4-dihydroxy-6-[18F]fluoro-L-phenylalanine/ FDOPA) is an amino acid PET tracer originally developed for brain imaging in patients with movement disorders but has been found to be useful in brain tumour imaging.
- Trial name
- FIG (NCT04870580)
- Testing
- Fluorodopa PET tracer
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University College, London
Gastrointestinal Complications, Prostate Cancer
RADICALS - Radiotherapy and Androgen Deprivation In Combination After Local Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells.
- Conditions
- Gastrointestinal Complications, Prostate Cancer, Sexual Dysfunction, Urinary Complications
- Trial name
- NCT00541047
- Testing
- bicalutamide, goserelin acetate, leuprolide acetate
- Where
- 58 sites in Canada, United Kingdom
- Volunteers
- 4,236 people
- Sponsor
- University College, London
Ornithine Transcarbamylase Deficiency
Halting Ornithine Transcarbamylase Deficiency With Recombinant AAV in ChildrEn
Ornithine transcarbamylase deficiency (OTCD) is an inherited metabolic liver disease which means that the body cannot maintain normal levels of ammonia.
- Trial name
- HORACE (NCT05092685)
- Testing
- AAVLK03hOTC
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Hereditary Sensory Neuropathy Type I
Hereditary Sensory Neuropathy Serine Trial
This is a randomised double-blind placebo-controlled trial of L-serine in Hereditary Sensory Neuropathy type 1 (HSN1) due to variants in SPTLC1/2 gene.
- Trial name
- SENSE (NCT06113055)
- Testing
- L-serine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Head and Neck Cancer
Photoacoustic Imaging of Head and Neck Tumours
Cancer is the commonest cause of death in the UK, and a national and international healthcare priority. Survival in the UK is relatively poor vs.
- Trial name
- NCT05073809
- Testing
- Photoacoustic Imaging Scan
- Sponsor
- University College, London
Obesity
Magnetic Resonance Imaging in Obesity
Obesity and its related conditions account for up to 5%of all health care spending in the UK and this is expected to double by 2030.
- Trial name
- NCT03528187
- Testing
- MRI, Written Consent
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University College, London
Exercise, Metabolism
Metabolic Responses to Exercise and Recovery
Exercise benefits health through diverse metabolic processes and is central to healthy ageing. However, intense exercise also challenges the body, causing cellular damage that must be repaired.
- Trial name
- NCT06088108
- Testing
- Cornell treadmill exercise protocol
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University College, London