Clinical trials: sponsored by University College, London
Muscle Tension Dysphonia, Vocal Fold Palsy
Evaluating the Feasibility of Acapella® Choice as a Dysphonia Treatment
A feasibility study to identify the immediate effect on the voices of patients with voice disorders (muscle tension dysphonia, vocal fold palsy or presbylaryngis) produced by exercising with Acapella Choice as a form of…
- Conditions
- Muscle Tension Dysphonia, Vocal Fold Palsy, Vocal Cord Paralysis, Presbylarynx
- Trial name
- NCT04764604
- Testing
- Acapella Choice, Tube-in-water
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Systemic Sclerosis, Limited Cutaneous Systemic Sclerosis
Mycophenolate in Limited Cutaneous Systemic Sclerosis (MINIMISE-Pilot)
Systemic sclerosis or scleroderma is an autoimmune condition that cause thickening and hardening of the skin, but can also affect internal organs.
- Trial name
- MINIMISE (NCT04927390)
- Testing
- Mycophenolate Mofetil 500mg
- Where
- 12 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- University College, London
Surgery, Surgical Incision
Direct Superior Approach (DSA) vs Posterior Approach (PA) in THA
Total Hip Arthroplasty (THA) is a highly effective treatment for patients with symptomatic hip osteoarthritis. The surgical approach in THA is important as it influences postoperative clinical recovery, functional outcomes, and…
- Conditions
- Surgery, Surgical Incision, Patient Satisfaction
- Trial name
- NCT04191993
- Testing
- Total hip arthroplasty
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Knee Osteoarthritis, Arthritis
Inflammatory Response Conventional Total Knee Replacement Versus Mako Total Knee Replacement
Total knee Arthroplasty (TKA) is a highly effective treatment for knee osteoarthritis. Mid- to long-term follow-up studies have shown good clinical outcomes following TKA; despite these results, there is a high incidence of…
- Conditions
- Knee Osteoarthritis, Arthritis, Surgery
- Trial name
- NCT04192006
- Testing
- Total Knee Arthroplasty
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
CD19+ Malignancies: Relapse Post-allogeneic Transplant
CAR19 Donor Lymphocytes for Relapsed CD19+ Malignancies Following Allogeneic Transplantation
Eligible patients will receive escalating doses of 4G7-CARD T-cells paralleling clinical standard of care with unmanipulated donor lymphocytes. There are 3 intra-patient dose levels planned.
- Trial name
- CARD (NCT02893189)
- Testing
- Infusion of modified CAR19 T-cells (4G7-CARD T-cells)
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease
GECo: Implementation and Effectiveness of COPD Case-Finding in Low and Middle Income Countries
This study will test how well short questionnaires, with and without a simple breathing test called 'peak flow', can identify people with COPD compared to the gold-standard diagnostic test called spirometry.
- Trial name
- GECo1 (NCT03365713)
- Where
- 3 sites in Nepal, Peru and 1 more
- Volunteers
- 10,709 people, healthy volunteers welcome
- Sponsor
- University College, London
Dementia, Caregiver Burden
Trialling an Online UK Dementia Awareness for Caregivers Course
The purpose of this study is to investigate whether an online Dementia Awareness Course is feasible for delivery and acceptable to informal caregivers of people living with dementia in the UK.
- Trial name
- DAC-UK (NCT05887063)
- Testing
- Dementia Awareness Course UK
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University College, London
Lung Cancer
Lung Screen Uptake Trial
This study tests the impact of a novel invitation strategy on attendance rates to a pre-lung cancer screening lung health check appointment.
- Trial name
- Lung-SCREEN (NCT02558101)
- Testing
- Control invitation materials, Intervention invitation materials
- Where
- United Kingdom
- Volunteers
- 1,997 people, healthy volunteers welcome
- Sponsor
- University College, London
Parkinson Disease, Parkinsonism
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular "Powerhouse") Dysfunction
Parkinson's disease (PD) is a progressive neurological disorder that is increasingly common with age, with the incidence rising from approximately 4 people per 10,000 in their forties to 2 in 100 over the age of eighty.
- Trial name
- SysMedPD (NCT03421899)
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University College, London
Healthy Volunteers
Stimulating Compassion UsingTranscutaneous Vagus Nerve Stimulation
This experimental proof-of-concept study in healthy volunteers investigates whether a specific form of self-relating, namely, self-compassion, can be controlled through non-invasive stimulation of the vagus nerve.
- Trial name
- NCT05441774
- Testing
- Active transcutaneous vagus nerve stimulation, Active self-compassion imagery
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Thrombotic Thrombocytopenic Purpura (TTP)
The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP)
TTP is a rare and serious blood disorder, characterized by the formation of small clots (micro thrombi) within the circulation and can be fatal.
- Trial name
- NCT00937131
- Testing
- Rituximab
- Where
- 3 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Tuberculosis
Predictive Values of Next Generation Interferon Gamma Release Assays for Latent Tuberculosis Infection
This study will assess the next generation of blood tests for latent TB infection, which may be able to indicate how treatment is working as well as in diagnosis infection.
- Trial name
- NextGen (NCT02512939)
- Testing
- blood test, not yet marketed, no trade name
- Where
- 5 sites in United Kingdom
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- University College, London
Iron Deficiency, Cardiac Patients
The UK CAVIAR Study
CAVIAR is a multicentre prospective observational study. Centres for cardiac and vascular surgery assess and manage patients in different ways before surgery.
- Conditions
- Iron Deficiency, Cardiac Patients, Anaemia, Vascular Patients
- Trial name
- NCT02637102
- Testing
- Not applicable - observational study
- Volunteers
- 425 people
- Sponsor
- University College, London
Transgenderism, Catheter Related Complication
Safe Access for Bladder Entry in Transgender Men Following Penile Reconstruction
Inserting a urinary catheter in transgender men following penile reconstruction is difficult and usually requires specialist input.
- Trial name
- SAFE (NCT04454970)
- Testing
- Urethrotech Urethral catheterisation device (UCD), Bardia Aquafil long term catheter
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University College, London
COVID-19
Mechanisms Underlying Long-term Fatigue and Exercise Intolerance Following COVID-19
The MEXICO study is an observational study that aims to identify underlying mechanisms contributing to exercise intolerance in the presence of persistent COVID-19 symptoms (Long COVID).
- Trial name
- MEXICO (NCT04914754)
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- University College, London
Drug Resistant Epilepsy
Lentiviral Gene Therapy for Epilepsy
This is a phase I/IIa clinical trial investigating the safety of a lentiviral epilepsy gene therapy using an engineered potassium channel in patients with refractory epilepsy.
- Trial name
- NCT04601974
- Testing
- lentiviral gene therapy
- Volunteers
- 10 people
- Sponsor
- University College, London
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia
18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia
Having bacteria in the blood can be very dangerous. This is called bacteraemia (or bacteremia) or bloodstream infection. It can lead to problems across the whole body, which is what happens in sepsis.
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia, Sepsis Bacterial, Bloodstream Infection
- Trial name
- PET-SAB (NCT05361135)
- Testing
- PET/CT
- Volunteers
- 820 people
- Sponsor
- University College, London
Primary Hyperaldosteronism, Primary Hyperaldosteronism Due to Adrenal Adenoma
Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas
High blood pressure (hypertension) causes strokes and heart attacks. While most patients need long-term treatment with pills, some have a cause which can be removed, curing the hypertension.
- Trial name
- FABULAS (NCT03405025)
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, ultrasound
- Where
- 3 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- University College, London
Colorectal Cancer, Pulmonary Metastases
A Randomised Trial of Pulmonary Metastasectomy in Colorectal Cancer
Patients who have been treated successfully for bowel cancer (colorectal cancer) sometimes go on to develop nodules of disease in another part of the body.
- Trial name
- PulMiCC (NCT01106261)
- Testing
- Metastasectomy, Active monitoring
- Where
- 24 sites in China, Italy and 2 more
- Volunteers
- 93 people
- Sponsor
- University College, London
Aortic Stiffness
Alcohol Consumption and Arterial Stiffness: A Longitudinal Study of Pulse Wave Velocity in the Whitehall II Cohort
Arterial stiffness is an important marker of cardiovascular health. Recent evidence from cross-sectional research has suggested it is associated with alcohol consumption.
- Trial name
- NCT02663791
- Where
- United Kingdom
- Volunteers
- 10,308 people
- Sponsor
- University College, London