Clinical trials: sponsored by University College, London
Healthy Volunteers
Stimulating Compassion UsingTranscutaneous Vagus Nerve Stimulation
This experimental proof-of-concept study in healthy volunteers investigates whether a specific form of self-relating, namely, self-compassion, can be controlled through non-invasive stimulation of the vagus nerve.
- Trial name
- NCT05441774
- Testing
- Active transcutaneous vagus nerve stimulation, Active self-compassion imagery
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Surgery-Complications, Safety Issues
Central London Patient Safety Research Collaboration
Patient safety is a priority for healthcare systems. In safe systems, patients would be saved from avoidable harm, both from their own conditions, and from the care and treatments provided to them.
- Trial name
- NCT05772195
- Where
- United Kingdom
- Volunteers
- 500,000 people
- Sponsor
- University College London Hospitals
Iron Deficiency, Cardiac Patients
The UK CAVIAR Study
CAVIAR is a multicentre prospective observational study. Centres for cardiac and vascular surgery assess and manage patients in different ways before surgery.
- Conditions
- Iron Deficiency, Cardiac Patients, Anaemia, Vascular Patients
- Trial name
- NCT02637102
- Testing
- Not applicable - observational study
- Volunteers
- 425 people
- Sponsor
- University College, London
Transgenderism, Catheter Related Complication
Safe Access for Bladder Entry in Transgender Men Following Penile Reconstruction
Inserting a urinary catheter in transgender men following penile reconstruction is difficult and usually requires specialist input.
- Trial name
- SAFE (NCT04454970)
- Testing
- Urethrotech Urethral catheterisation device (UCD), Bardia Aquafil long term catheter
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University College, London
Tuberculosis
Predictive Values of Next Generation Interferon Gamma Release Assays for Latent Tuberculosis Infection
This study will assess the next generation of blood tests for latent TB infection, which may be able to indicate how treatment is working as well as in diagnosis infection.
- Trial name
- NextGen (NCT02512939)
- Testing
- blood test, not yet marketed, no trade name
- Where
- 5 sites in United Kingdom
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- University College, London
COVID-19
Mechanisms Underlying Long-term Fatigue and Exercise Intolerance Following COVID-19
The MEXICO study is an observational study that aims to identify underlying mechanisms contributing to exercise intolerance in the presence of persistent COVID-19 symptoms (Long COVID).
- Trial name
- MEXICO (NCT04914754)
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- University College, London
Thrombotic Thrombocytopenic Purpura (TTP)
The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP)
TTP is a rare and serious blood disorder, characterized by the formation of small clots (micro thrombi) within the circulation and can be fatal.
- Trial name
- NCT00937131
- Testing
- Rituximab
- Where
- 3 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia
18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia
Having bacteria in the blood can be very dangerous. This is called bacteraemia (or bacteremia) or bloodstream infection. It can lead to problems across the whole body, which is what happens in sepsis.
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia, Sepsis Bacterial, Bloodstream Infection
- Trial name
- PET-SAB (NCT05361135)
- Testing
- PET/CT
- Volunteers
- 820 people
- Sponsor
- University College, London
Drug Resistant Epilepsy
Lentiviral Gene Therapy for Epilepsy
This is a phase I/IIa clinical trial investigating the safety of a lentiviral epilepsy gene therapy using an engineered potassium channel in patients with refractory epilepsy.
- Trial name
- NCT04601974
- Testing
- lentiviral gene therapy
- Volunteers
- 10 people
- Sponsor
- University College, London
Cardiovascular Diseases, B-cell Acute Lymphoblastic Leukemia
CAR T Cell Therapy Related Cardiovascular Outcomes
This will be a cohort study of all patients receiving Cluster of Differentiation 19 (CD19)-specific CAR T cell therapy for relapsed/refractory B cell haematological malignancies.
- Conditions
- Cardiovascular Diseases, B-cell Acute Lymphoblastic Leukemia, B-cell Lymphoma Refractory, B-cell Lymphoma Recurrent
- Trial name
- CARTCO (NCT05130489)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University College London Hospitals
Primary Hyperaldosteronism, Primary Hyperaldosteronism Due to Adrenal Adenoma
Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas
High blood pressure (hypertension) causes strokes and heart attacks. While most patients need long-term treatment with pills, some have a cause which can be removed, curing the hypertension.
- Trial name
- FABULAS (NCT03405025)
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, ultrasound
- Where
- 3 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- University College, London
Aphasia, Anomic
Mechanisms Underlying Spoken Language Production
Most of us take being able to communicate for granted. Anomia (word finding problems) after stroke can cause profound frustration and anxiety for patients and families. Some people recover; many don't.
- Trial name
- NCT04138433
- Testing
- Real tDCS
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University College London Hospitals
Stroke
App-delivered Therapy for Arabic Readers With Hemianopic Alexia
Hemianopia refers to compromised vision in one half of the visual field, in either one or both eyes. Hemianopic Alexia (HA) is a reading disorder related to such impairment, usually caused by stroke or head injury.
- Trial name
- NCT02482350
- Testing
- Reading Training
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Renal Transplant Rejection, Renal Transplant Infection
NOMINATE/ Minimisation of Immunosuppression in Kidney Transplantation
Kidney transplantation provides the optimal form of kidney replacement therapy for the majority of people with end-stage kidney disease, and has now become the commonest form of kidney replacement therapy.
- Trial name
- NCT05073822
- Testing
- Tacrolimus
- Sponsor
- University College, London
Colorectal Cancer, Pulmonary Metastases
A Randomised Trial of Pulmonary Metastasectomy in Colorectal Cancer
Patients who have been treated successfully for bowel cancer (colorectal cancer) sometimes go on to develop nodules of disease in another part of the body.
- Trial name
- PulMiCC (NCT01106261)
- Testing
- Metastasectomy, Active monitoring
- Where
- 24 sites in China, Italy and 2 more
- Volunteers
- 93 people
- Sponsor
- University College, London
Aortic Stiffness
Alcohol Consumption and Arterial Stiffness: A Longitudinal Study of Pulse Wave Velocity in the Whitehall II Cohort
Arterial stiffness is an important marker of cardiovascular health. Recent evidence from cross-sectional research has suggested it is associated with alcohol consumption.
- Trial name
- NCT02663791
- Where
- United Kingdom
- Volunteers
- 10,308 people
- Sponsor
- University College, London
Stroke, Brain Injuries
Clinical Effectiveness of iReadMore for People With Alexia
iReadMore will provide an app-based therapy for people with pure or central alexia. This study aims to test the clinical effectiveness of iReadMore for improving reading accuracy and speed in real world users of the therapy.
- Conditions
- Stroke, Brain Injuries, Aphasia, Alexia
- Trial name
- NCT04849091
- Testing
- iReadMore
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Depression, Parkinson Disease
Antidepressants Trial in Parkinson's Disease
This is a randomised trial in a NHS setting, comparing the clinical effectiveness and cost-effectiveness of the selective serotonin reuptake inhibitor, escitalopram, and of the tricyclic antidepressant, nortriptyline, to placebo…
- Trial name
- ADepT-PD (NCT03652870)
- Testing
- Nortriptyline, Escitalopram
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University College, London
Liver Transplantation, Renal Failure
A Feasibility Study of Octreotide Infusion During Liver Transplant.
The purpose of the study is to determine whether an octreotide infusion during liver transplantation improves renal outcomes, intraoperative blood pressure and reduces haemorrhage and transfusion requirement.
- Trial name
- Octreotide (NCT04941911)
- Testing
- Octreotide Acetate
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Diffuse Large B-Cell Lymphoma
Evaluation of CAR19 T-cells as an Optimal Bridge to Allogeneic Transplantation
The purpose of this study is to administer novel cluster of differentiation antigen 19 (CD19) specific Chimeric Antigen Receptor T-cells (CAR19 T-cells) to patients with relapsed or resistant Diffuse Large B Cell Lymphoma (DLBCL)…
- Trial name
- COBALT (NCT02431988)
- Testing
- Leukapheresis, Cyclophosphamide, Fludarabine
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London