Clinical trials: sponsored by University College, London
Frailty, Cardiovascular Diseases
MultiMorbidity Life-Course Approach To Myocardial Health -A Cardiac Sub-Study of the MRC National Survey of Health and Development (NSHD)
Background The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence.
- Trial name
- MyoFit46 (NCT05455125)
- Testing
- CMR CGI
- Where
- United Kingdom
- Volunteers
- 550 people
- Sponsor
- University College, London
Essential Tremor
Neurophysiologic Assessment of ET Patients Treated by Vim DBS
Essential tremor is a chronic and progressive neurological disease characterized by upper limb tremor. This is one of the most frequent movement disorders.
- Trial name
- NCT05362448
- Testing
- Frequency
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College London Hospitals
Tracheostomy
Concordance of Methods to Select Tracheostomy Tube Size for Adults in Intensive Care
This study is part of a larger PhD project. The aim of the overall project is to provide evidence to help healthcare staff choose the best size tracheostomy breathing tube for patients in intensive care.
- Trial name
- COMETS (NCT05047432)
- Testing
- Non-interventional trial
- Where
- United Kingdom
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University College, London
Schizophrenia, Schizoaffective Disorder
Research Into Antipsychotic Discontinuation and Reduction Trial
Psychosis and schizophrenia are common and costly mental health problems. Psychosis is the name given to a group of mental conditions in which cause people to perceive or interpret things differently from those around them.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Delusional Disorder, Schizophreniform Disorders
- Trial name
- NCT03559426
- Testing
- Antipsychotic Reduction, Antipsychotic Maintenance
- Where
- United Kingdom
- Volunteers
- 253 people
- Sponsor
- University College, London
SARS-CoV Infection
SARS-CoV-2 (COVID-19) Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity (Legacy Study)
The study aims to investigate SARS-CoV-2 susceptibility, transmission and disease severity in healthcare workers and patients. Residual specimens from an existing collection of samples in viral inactivating buffer and derivatives…
- Trial name
- NCT04750356
- Where
- 3 sites in United Kingdom
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Tracheostomy Complication, Covid19
A Cohort Study of Mechanically Ventilated COVID-19 Patients Undergoing Tracheostomy
COVIDTrach aims to assess the outcomes of tracheostomy in mechanically ventilated patients with COVID-19. The use of personal protective equipment and incidence of COVID-19 amongst operators is also recorded.
- Conditions
- Tracheostomy Complication, Covid19, Ventilator Lung
- Trial name
- COVIDTrach (NCT04572438)
- Testing
- Tracheostomy
- Where
- United Kingdom
- Volunteers
- 2,234 people
- Sponsor
- University College, London
Fetal Growth Retardation
EVERREST Developing a Therapy for Fetal Growth Restriction
Fetal Growth Restriction (FGR) is a major obstetric problem, affecting 1.46 million fetuses worldwide each year and contributing to 50% of stillbirths.
- Trial name
- EVERREST (NCT02097667)
- Where
- 4 sites in Germany, Spain and 2 more
- Volunteers
- 142 people
- Sponsor
- University College, London
Prematurity, Neonatal Encephalopathy
Evaluating the NeoTree in Malawi and Zimbabwe
Neonatal mortality remains unacceptably high. Globally, the majority of mothers now deliver in health facilities in low resource settings where quality of newborn care is poor.
- Conditions
- Prematurity, Neonatal Encephalopathy, Neonatal Sepsis, Neonatal Death
- Trial name
- NCT05127070
- Testing
- Neotree
- Where
- 5 sites in Malawi, Zimbabwe
- Volunteers
- 19,000 people
- Sponsor
- University College, London
Obesity
A Pilot Study to Assess the Impact of Exposure to Popular Media Content on Patients Living With Obesity
This study will explore the impact of exposure to popular media content on patients living with obesity. Findings from this study will provide new insights that will extend current understanding of exposure to media portrayal.
- Trial name
- NCT05001633
- Testing
- modified media content paradigm, control
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Challenging Behaviour
Evaluation of Parent Intervention for Challenging Behaviour in Children With Intellectual Disabilities (EPICC-ID)
Children with intellectual disabilities are likely to present with challenging behaviour. Parent mediated interventions have shown utility in influencing child behaviour, although there is a paucity of UK research into…
- Trial name
- NCT03086876
- Testing
- Level 4 Stepping Stones Triple P (SSTP)
- Where
- 4 sites in United Kingdom
- Volunteers
- 261 people
- Sponsor
- University College, London
Dilated Cardiomyopathy
The Arrhythmogenic Potential of Midwall Septal Fibrosis in Dilated Cardiomyopathy
Midwall septal fibrosis (MSF) is a common structural abnormality in non-ischaemic dilated cardiomyopathy (DCM). Its presence is believed to increase the risk of malignant ventricular arrhythmias (VA), but the mechanism of…
- Trial name
- DCM-MSF (NCT05026112)
- Testing
- ECG-Imaging, Cardiac MRI scan
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Critical Illness, Rehabilitation
Feasibility@48: Cross Sectional Study of Intensive Care Unit Mobility Practices Across the United Kingdom
Intensive Care Unit (ICU) patients commonly experience muscle loss at a rate of 2-3% day. Traditionally, critically ill patients have been managed in bed, however current research suggests that prolonged bedrest cause mechanical…
- Trial name
- NCT05281705
- Where
- United Kingdom
- Volunteers
- 750 people
- Sponsor
- University College, London
Dementia, Dementia, Vascular
Virtual Individual Cognitive Stimulation Therapy: a Proof of Concept Study
Due to COVID-19, the routine treatment for dementia, Cognitive Stimulation Therapy (CST), is currently suspended in multiple countries. Access to treatment is, therefore, paramount.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- V-iCST (NCT04828434)
- Testing
- Virtual Individual Cognitive Simulation Therapy
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Autism Spectrum Disorder
Efficacy of Vivomixx on Behaviour and Gut Function in Autism Spectrum Disorder
The purpose of this study is to assess the effects of 3 months supplementation with the multi strain probiotic Vivomixx on the overall function, aberrant behaviours and frequency of gastrointestinal symptoms in children with…
- Trial name
- VIVO-ASD (NCT03369431)
- Testing
- Vivomixx
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University College, London
Covid-19, Nosocomial Infection
COG-UK Project Hospital-Onset COVID-19 Infections Study
Hospitals are recognised to be a major risk for the spread of infections despite the availability of protective measures. Under normal circumstances, staff may acquire and transmit infections, but the health impact of within…
- Conditions
- Covid-19, Nosocomial Infection, Coronavirus, Coronavirus Infection
- Trial name
- COG-UK HOCI (NCT04405934)
- Testing
- Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures
- Where
- United Kingdom
- Volunteers
- 2,170 people
- Sponsor
- University College, London
Health Care Worker Patient Transmission, Coronavirus
COVID-19: Healthcare Worker Bioresource: Immune Protection and Pathogenesis in SARS-CoV-2
Modelling repurposed from pandemic influenza is currently informing all strategies for SARS-CoV-2 and the disease COVID-19. A customized disease specific understanding will be important to understand subsequent disease waves…
- Conditions
- Health Care Worker Patient Transmission, Coronavirus, Coronavirus Infections, Immunological Abnormality
- Trial name
- COVID19-HCW (NCT04318314)
- Testing
- COPAN swabbing and blood sample collection
- Where
- 2 sites in United Kingdom
- Volunteers
- 731 people
- Sponsor
- University College, London
Trigeminal Neuralgia
Defining Core Outcome Sets in Trigeminal Neuralgia
The aim of this study is to determine what patients with trigeminal neuralgia (TN), clinicians and researchers in the field, consider to be the most important outcomes to be expected after undergoing treatment for trigeminal…
- Trial name
- TRINCOS (NCT04272385)
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University College, London
Anosmia, SARS CoV 2 Infection
Anosmia and Covid-19
Our study aims to determine the prevalence of anosmia in patients SARS-Cov-2/Covid-19 infection (both by symptom reporting and smell testing), the efficacy of early olfactory training for the treatment of anosmia caused by…
- Trial name
- COVANOS (NCT05246059)
- Testing
- Olfactory Training
- Where
- 4 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- University College, London
Appendicitis
The Role of Imaging in the Diagnosis of Acute Appendicitis During the COVID-19 Pandemic
This is a retrospective observational study in the form of a cohort study evaluating the use of pre-operative imaging for the diagnosis of acute appendicitis in a tertiary centre during the first and second waves of the COVID-19…
- Trial name
- NCT05205681
- Testing
- Pre-operative imaging
- Where
- United Kingdom
- Volunteers
- 313 people
- Sponsor
- University College London Hospitals
Terminal Illness
ADJUST: A Study on MDT Prognostication
This study investigates how clinicians form intuitive judgements about the prognoses of palliative care patients after receiving advice perceived as coming from either a team member or an algorithm.
- Trial name
- ADJUST (NCT04568629)
- Testing
- Advice from the PiPS-B14 prognostic tool, Advice from another clinician
- Where
- United Kingdom
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- University College, London