Clinical trials: sponsored by University College, London
COVID19
Let It Out (LIO) and COVID19: Testing an Online Emotional Disclosure-based Intervention During the COVID19 Pandemic
A randomised controlled trial designed to test whether an online expressive writing intervention (LIO-C) can reduce distress for English-speaking adults during the global COVID19 pandemic.
- Trial name
- LIO-C (NCT04386668)
- Testing
- Let It Out (LIO)-C, Neutral writing control
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University College, London
COPD
Protein Supplementation to Enhance Exercise Capacity in COPD
Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung disease. Pulmonary Rehabilitation (PR) is a six-week supervised group exercise and education class.
- Trial name
- NCT04027413
- Testing
- fortisip compact protein, preOp
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University College, London
Dementia, Dementia, Vascular
Advanced Cognitive Stimulation Therapy Hong Kong (ACST-HK)
This study is a feasibility randomized controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia in Hong Kong.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- NCT04555629
- Testing
- Advanced Cognitive Stimulation Therapy Hong Kong
- Volunteers
- 32 people
- Sponsor
- University College, London
DEM, Dementia
Advanced Cognitive Stimulation Therapy (ACST)
This study is a feasibility randomised controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia.
- Conditions
- DEM, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT04550975
- Testing
- Advanced Cognitive Stimulation Therapy
- Volunteers
- 32 people
- Sponsor
- University College, London
Renal Cell Carcinoma
Renal Adjuvant MultiPle Arm Randomised Trial
RATIONALE: The current global standard of care after nephrectomy for localised RCC therefore remains active monitoring (i.e., observation by clinical and radiological means).
- Trial name
- RAMPART (NCT03288532)
- Testing
- Durvalumab, Tremelimumab
- Where
- 35 sites in United Kingdom
- Volunteers
- 1,750 people
- Sponsor
- University College, London
Sleep
Exploring the Impact of a Sleep App on Sleep Quality
Sufficient sleep is crucial for good health, yet a third of UK adults have impaired sleep quality. Therefore, there is urgent need for population-level sleep interventions.
- Trial name
- NCT04487483
- Testing
- Sleep App
- Where
- United Kingdom
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University College, London
Ulcer, Skin Ulcer
Epidermal Grafting in Wound Healing
Split thickness skin grafting is the normal standard of care for wound closure. However, this is an invasive procedure and associated with pain also there can be additional donor site morbidity.
- Conditions
- Ulcer, Skin Ulcer, Wounds and Injuries
- Trial name
- EPIGRAAFT (NCT02535481)
- Testing
- Epidermal grafting, Split thickness skin grafting
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University College, London
Sensory Hearing Loss, Sensorineural Hearing Loss
The SeaSHeL National Prospective Cohort Study
Each year, approximately 15,000 people in the United Kingdom experience sudden loss of hearing that is sensorineural in nature. In the majority of cases, the cause is unknown despite investigation, and these cases are termed…
- Conditions
- Sensory Hearing Loss, Sensorineural Hearing Loss, Sensorineural Hearing Loss in Left Ear, Sensorineural Hearing Loss in Right Ear
- Trial name
- SeaSHeL (NCT04108598)
- Testing
- Quality of life questionnaire
- Where
- United Kingdom
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- University College, London
Spinal Cord Injuries
Spinal Stimulation Sit-to-Stand Training After Spinal Cord Injury
An injury to the spinal cord can be life altering: with a 'complete' injury, the affected individual is unable to move their legs at all and may become wheelchair-bound.
- Trial name
- Stim2Stand (NCT03536338)
- Testing
- Spinal Stimulation, Sit-to-stand Training
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University College, London
Obesity, Bariatric Surgery Candidate
Investigating the Role of Ghrelin in Regulating Appetite and Energy Intake in Patients Following Bariatric Surgery (BARI-INSIGHT)
Bariatric surgery helps patients with severe obesity to lose weight, cures and prevents diseases linked to obesity and reduces the risk of death.
- Conditions
- Obesity, Bariatric Surgery Candidate, Appetitive Behavior
- Trial name
- BARI-INSIGHT (NCT03641417)
- Testing
- GLWL-01
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University College, London
Endometrial Neoplasms
Diet and Physical Activity in Uterine Cancer Survivors
Endometrial cancer is the most common gynaecological cancer in developed countries with more than 75% of the patients surviving for at least five years.
- Trial name
- DEUS (NCT02433080)
- Testing
- Shape-Up following cancer treatment
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
COV-HI, COVID-19
COVID-19 Hyperinflammation Syndrome (COV-HI): Protocol for a Rapidly Executed Cohort Study
Based on emerging experience and trials from countries affected early by the COVID-19 (COV19) pandemic, there is evidence that a subgroup of severely affected people develop a hyperinflammatory (HI) syndrome (COV-HI).
- Conditions
- COV-HI, COVID-19, COVID-19 (COV) Hyperinflammatory (HI) Syndrome
- Trial name
- COV-HI (NCT04385069)
- Where
- 5 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Auditory Processing Disorder
Effects of Remote Microphone Hearing Aids on Children With Auditory Processing Disorder
Auditory Processing Disorder (APD) is a disorder where the functions of the ear are normal, but the person has difficulty identifying or discriminating sounds and experiences listening difficulties in noise.
- Trial name
- NCT02353091
- Testing
- Remote Microphone Hearing Aids
- Volunteers
- 26 people
- Sponsor
- University College, London
Lupus Erythematosus, Systemic
The Role of Lipids in Immune Cell Function in SLE Patients
The overall aim of this project is to investigate the different types of immune cells found in the blood of patients with Systemic Lupus Erythematosus (SLE) and healthy donors.
- Trial name
- NCT04361734
- Testing
- Blood sampling to include Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Multiple Sclerosis
Regulation of Lipid Metabolism in Autoimmune Disease: Multiple Sclerosis
The aim of this research is to understand how lipids such as cholesterol affect the disease process in people with MS.
- Trial name
- RELOAD-MS (NCT04053374)
- Testing
- Blood sampling
- Where
- 2 sites in United Kingdom
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University College, London
Renal Insufficiency
Clinical Study of POSS-PCU Vascular Grafts for Vascular Access
This study evaluates the safety and performance of a new vascular graft made of POSS-PCU as a vascular access conduit for haemodialysis.
- Trial name
- NCT02301312
- Testing
- POSS-PCU vascular graft
- Volunteers
- 30 people
- Sponsor
- University College, London
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Parkinson Disease
Ambroxol in Disease Modification in Parkinson Disease
This study will evaluate the safety, tolerability and pharmacodynamics of ambroxol in participants with Parkinson Disease. Participants will administer ambroxol at five dose levels and will undergo clinical assessments, lumbar…
- Trial name
- AiM-PD (NCT02941822)
- Testing
- Ambroxol
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London
Terminal Illness
ORaClES: A Trial to Improve Prognostication
This study evaluates whether an online training resource can improve the performance of medical students in recognising imminently dying palliative care patients.
- Trial name
- ORaClES (NCT03360812)
- Testing
- Online training resource
- Where
- 5 sites in United Kingdom
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University College, London
Oral Epithelial Dysplasia, Precancerous Conditions
Oral Epithelial Dysplasia Informational Needs Questionnaire
Background: Oral epithelial dysplasia (OED) is a condition with an increased risk of oral cancer. Due to the current changes in the factors associated with these diseases (because of human papillomavirus), it is expected that…
- Conditions
- Oral Epithelial Dysplasia, Precancerous Conditions, Precancerous Lesions, Oral Lichen Planus
- Trial name
- ODIN-Q (NCT04153266)
- Testing
- No intervention is planned for this study
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London