Clinical trials: sponsored by University College, London
Oral Lichen Planus
The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus
Oral Lichen Planus (OLP) is an inflammatory disease of mucosal and skin with unknown etiology. The prevalence rate in England is reported to be between 1-2.4%.
- Trial name
- CABRIO (NCT03052179)
- Testing
- Poly-biotic
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Ehlers-Danlos Syndrome
Origins and Impact of EDS in Connective Tissues and Skin
Ehlers-Danlos Syndrome (EDS) is an inherited disease of collagen, found in connective tissues, such as skin. EDS patients suffer from joint and skin problems (skin hyperextensibility, joint hypermobility) along with a large range…
- Trial name
- NCT02721797
- Testing
- Orthopaedic & Gynaecology surgery
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University College, London
Palliative Care, Terminal Illness
The Surprise Study
This study investigates the use of the Surprise Question [SQ] (would you be surprised if this patient were to die in the next 12 months?) in routine practice.
- Trial name
- NCT03697213
- Testing
- Online study
- Where
- 6 sites in Belgium, Germany and 4 more
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University College, London
Functional Neurological Disorders
The Pathophysiology of Functional Neurological Disorders
Functional disorders, also called psychogenic or psychosomatic are very common, disabling and their costs to society are immense.
- Trial name
- NCT02905877
- Testing
- Behavioural study
- Where
- United Kingdom
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University College, London
Prostate Cancer
CombIning advaNces in imagiNg With biOmarkers for improVed Diagnosis of Aggressive prosTate cancEr
To enable the paradigm of mp-MRI before biopsy in all patients with suspected prostate cancer by better selecting patients who will benefit from diagnostic MRI and by improving the performance of the mp-MRI itself
- Trial name
- INNOVATE (NCT02689271)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 365 people
- Sponsor
- University College, London
Depression
RESIST: Understanding the Role of Depression in Heart Disease
This study will investigate the biological pathways involved in anti-depressant resistance that increase risk of cardiovascular disease in people with depression.
- Trial name
- NCT02657798
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University College, London
Critical Care
Measuring Physical Activity Levels in Critical Care
The study will be a single-centre, prospective observational study to evaluate the use of a wearable accelerometer device to measure physical activity levels of patients within critical care.
- Trial name
- ACTIVE (NCT03454880)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
HIV
Depletion of Serum Amyloid P Component to Enhance the Immune Response to DNA Vaccination
This is a clinical proof-of-concept (PoC) study of DNA vaccination after SAP depletion. The investigators will measure the immune responses to DNA vaccination against HIV-1 in healthy adult male volunteers, comparing a group in…
- Trial name
- HIV-CORE003 (NCT02425241)
- Testing
- pSG2.HIVconsv DNA vaccine, ChAdV63.HIVconsv booster vaccine, MVA.HIVconsv booster vaccine
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University College, London
Hearing Loss
Big Data Supporting Public Health Hearing Policies
Hearing Loss (HL) affects over 5% of the world's population (WHO 2014) and is the 5th leading cause of Years Lived with Disability. HL is currently managed with Hearing Aids (HAs), i.e.
- Trial name
- EVOTION (NCT03316287)
- Testing
- Hearing aid, Mobile phone, Sensor
- Where
- United Kingdom
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University College, London
Glaucoma, Retinal Disease
The EASE Study - Human Factor and Usability Testing of a Binocular OCT System
Ophthalmology is among the most technology driven of all medical specialties, with advanced medical imaging devices - and specialised computer software - increasingly adopted for routine clinical use.
- Conditions
- Glaucoma, Retinal Disease, Strabismus, Healthy Volunteers
- Trial name
- EASE (NCT02822612)
- Testing
- Binocular OCT prototype
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University College, London
Secondary Progressive Multiple Sclerosis
MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial
Multiple sclerosis (MS) is a disabling and progressive neurological disease that affects approximately 100,000 people in the UK.
- Trial name
- MS-SMART (NCT01910259)
- Testing
- Amiloride, Riluzole, Fluoxetine
- Where
- 13 sites in United Kingdom
- Volunteers
- 445 people
- Sponsor
- University College, London
Prostate Cancer
The Prostate Liquid Study (PLiS)
A multi-site study to evaluate the potential use of the ChEC test of seminal fluid as an additional triage test in stratifying patients for further tests.
- Trial name
- PLiS (NCT04102904)
- Testing
- Observational
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Breast Neoplasm Female
Breast PET Feasibility
Breast PET may be able to help in the diagnostic pathway in patients to determine which ones need to go on to have a second look ultrasound +/- biopsy and those who need to be sent for MRI guided biopsy.
- Trial name
- Breast PET (NCT03198442)
- Testing
- F-18 FDG breast PET scan
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Musculoskeletal Pain, Cognitive Change
Health, Wellbeing and Performance in Law Enforcement Workers
This study aims to assess current health and fitness of law enforcement workers in various roles, and to evaluate the impact of an exercise intervention on markers on physical and mental wellbeing in this population.
- Conditions
- Musculoskeletal Pain, Cognitive Change, Occupational Stress, Inflammation
- Trial name
- NCT04204486
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University College, London
Stroke
An Evaluation of a New Nonverbal Treatment for Global Aphasia
People with global aphasia (PwGA) post stroke have little to no meaningful communication abilities (ie limited comprehension, spoken language, reading and writing abilities).A proportion of PwGA will also have limited abilities…
- Trial name
- NCT02545894
- Testing
- Cognitive therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Word Finding Difficulty, Communication Disorders
Intervention for Fluency Difficulty
The focus of the study is to identify children with word-finding difficulty and other speech and communication difficulties such as stuttering, a procedure referred to as screening.
- Trial name
- FIST (NCT04217460)
- Testing
- Intervention for fluency difficulty
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Wilson's Disease
Cohort Research on Wilson's Disease
Wilson's disease (WD) is an inherited disorder that causes abnormal copper accumulation in the brain and/or liver. Some people develop neurological or psychiatric symptoms whereas other develop liver disease.
- Trial name
- CROWD (NCT04212195)
- Testing
- Next generation sequencing, Imaging and fluid biomarkers
- Where
- 11 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Treatment Adherence and Compliance
Quality and Effectiveness of a Personalised App to Support Patients With Fixed Braces
Mobile phones are potentially an invaluable tool in improving adherence, they are readily available and can utilised to deliver several approaches to improve adherence simultaneously.
- Trial name
- NCT04184739
- Testing
- My Braces App
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University College, London
Lung Cancer - Malignant Pleural Mesothelioma
Ganetespib With Platinum, in Patients With Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is a rapidly lethal cancer arising from the parietal pleural mesothelium, and is associated with exposure to asbestos.
- Trial name
- MESO-02 (NCT01590160)
- Testing
- Ganetespib
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University College, London
Lymphoma, Leukemia
Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation
RATIONALE: Following stem cell transplantation, a major risk is graft-versus-host disease (GVHD). This occurs when donor immune cells that have been infused recognise the host's cells as 'foreign' and attack these cells.
- Conditions
- Lymphoma, Leukemia, Myeloma, Myelodysplastic Syndromes
- Trial name
- ToTem (NCT03836690)
- Testing
- CD62L- Tem
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University College, London