Clinical trials: sponsored by University College, London
Faecal Incontinence, Fecal Incontinence
Assessment of Faecal Incontinence With MAPLe
Faecal incontinence (FI) is the involuntary passage of gas, liquid or solid stool and is experienced by an estimated 1-10% of the population. The symptom is multifactorial and associated with many medical conditions and diseases.
- Conditions
- Faecal Incontinence, Fecal Incontinence, Faecal Incontinence With Faecal Urgency
- Trial name
- NCT03969069
- Testing
- MAPLe
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- University College London Hospitals
Ovarian Cancer, Fallopian Tube Cancer
Low Dose Cyclophosphamide +/-- Nintedanib in Advanced Ovarian Cancer
The primary objective is to explore the efficacy and safety of an all oral combination of BIBF 1120 (an inhibitor of angiogenic signalling) and metronomic cyclophosphamide in patients with multiply-relapsed advanced ovarian…
- Trial name
- METRO-BIBF (NCT01610869)
- Testing
- BIBF 1120
- Where
- 16 sites in United Kingdom
- Volunteers
- 117 people
- Sponsor
- University College, London
Parkinson's Disease
The CloudUPDRS Smartphone Software in Parkinson's Study.
This study compares the validity and usability of smartphone software for home monitoring of symptoms and signs in Parkinson's disease as compared to the current clinical gold standard - the Unified Parkinsons Disease Rating…
- Trial name
- CUSSP (NCT02937324)
- Testing
- CloudUPDRS smartphone software assessment, Clinical assessment
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Dehydration Hypertonic
Thirst-guided Subject-controlled Rehydration in Healthy Volunteers
Water is largest single component to the human body and is requisite for numerous essential metabolic processes. Dehydration refers to deficient body water content and is prevalent in healthcare.
- Trial name
- NCT03932890
- Testing
- Patient controlled fluid device administering high volume thirst guided fluid bolus, Patient controlled fluid device administering low volume thirst guided fluid bolus
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University College, London
Ovarian Cancer, Fallopian Tube Cancer
The Activity of TroVax® Versus Placebo in Relapsed Asymptomatic Ovarian Cancer
The purpose of this trial is to assess the effectiveness of TroVax® compared to placebo in extending the time to progression in patients with asymptomatic relapsed platinum resistant ovarian, fallopian tube or primary peritoneal…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- TRIOC (NCT01556841)
- Testing
- TroVax®
- Where
- 12 sites in United Kingdom
- Volunteers
- 94 people
- Sponsor
- University College, London
Women With Early Breast Cancer, Breast Conserving Surgery
Health Status of Women With Breast Cancer
The quality-adjusted life-year (QALY) is the outcome measure of choice in England and Wales for National Institute for Health and Care Excellence (NICE). To be able to conduct a cost utility analysis, QALY data is required.
- Conditions
- Women With Early Breast Cancer, Breast Conserving Surgery, Radiotherapy
- Trial name
- OSTaRa (NCT03761940)
- Testing
- EQ5D questionnaire and a demographic questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Glaucoma
Primary Glaucoma Treatment Trial in Kenya and South Africa - SLT vs. Medication
Multi-centre randomised controlled trial of selective laser trabeculoplasty compared with prostaglandin analogue therapy as primary treatment for high tension open angle glaucoma.
- Trial name
- SLT/med (NCT02774811)
- Testing
- Prostaglandin analogue, Selective laser trabeculoplasy, laser
- Where
- Kenya
- Volunteers
- 15 people
- Sponsor
- University College, London
Shock, Sepsis
Surrogate of Adequate Perfusion: Bladder Tissue Oxygen Monitoring
The extent and duration of tissue hypoxia is a major determinant of outcome following major, high-risk surgery and in critical illness.
- Conditions
- Shock, Sepsis, Surgery
- Trial name
- SoAP-BOx (NCT03935477)
- Testing
- WellBeing catheter
- Where
- United Kingdom
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Multiple Myeloma
Bortezomib Consolidation Trial
The aim of this trial is to determine whether bortezomib improves response and delays progression for multiple myeloma patients after high dose therapy and autologous stem cell transplant.
- Trial name
- BCT (NCT01517724)
- Testing
- Bortezomib
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Parkinson's Disease
Short Pulse Width DBS in Parkinson's Disease
The aim of this investigation is to explore the effect of reducing conventional pulse width of stimulation on known adverse effects of Subthalamic nucleus Deep Brain Stimulation (STN DBS) treatment such as; slurring of speech…
- Trial name
- NCT03417271
- Testing
- Deep brain stimulation
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
PHYSICAL FITNESS
Feasibility, Acceptability and the Effects of Two Publicly Available Physical Activity Mobile Apps
Within the new digital health care landscape, the rise of health applications (apps) creates novel prospects for behaviour change opportunities.
- Trial name
- NCT03565627
- Testing
- Exercise app: 7 Minute Workout Challenge, Running app: One You Couch to 5K
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University College, London
Breast Cancer
Enabling the Study of Metabolism in Breast Cancer Through Collection of Fresh-tissue Biopsies
This study aims to evaluate how breast cancer cells metabolise nutrients in order to grow. Patients enrolled into this study will undergo a research biopsy that will aim to collect up to 4 cores of tumour tissue.
- Trial name
- ENSEMBLE (NCT03880097)
- Testing
- Research Biopsy
- Volunteers
- 240 people
- Sponsor
- University College, London
Graft Versus Host Disease, Leukemia
Donor Lymphocyte Infusion After Stem Cell Transplant in Treating Patients With Haematological Cancers
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and melphalan, before a donor stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Myeloma
- Trial name
- ProT4 (NCT01240525)
- Testing
- CD4 DLI, No DLI
- Where
- 11 sites in United Kingdom
- Volunteers
- 114 people
- Sponsor
- University College, London
TTP - Thrombotic Thrombocytopenic Purpura
The United Kingdom Thrombotic Thrombocytopenic Purpura Registry (UK TTP Registry)
This is a UK (United Kingdom) based registry, involving all sites treating newly presenting Thrombotic Thrombocytopenic Purpura (TTP). From this registry, important epidemiological data will be obtained.
- Trial name
- NCT03832881
- Testing
- ADAMTS13, VWF assay
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University College, London
Squamous Cell Lung Cancer, Lung Cancer
Photodynamic Therapy for the Prevention of Lung Cancer
PEARL is a phase III multicentre 2:1 randomised controlled trial, with an incorporated phase II (pilot) component. All patients consented/registered onto the trial will have an autofluorescence bronchoscopy (AFB) to check for the…
- Trial name
- PEARL (NCT03346304)
- Testing
- Photodynamic Therapy (PDT)
- Sponsor
- University College, London
Prostatic Neoplasms, Diagnostic Techniques and Procedures
SmartTarget: BIOPSY
The purpose of this study is to determine how well SmartTarget guided prostate biopsies perform, compared with our current standard of "visually directed biopsies" in the detection of prostate cancer.
- Trial name
- NCT02341677
- Testing
- SmartTarget - Biopsy
- Where
- United Kingdom
- Volunteers
- 134 people
- Sponsor
- University College, London
Cancer
Acceptability and Feasibility Study of Patient-specific 'Tumouroids' as Personalised Treatment Screening Tools
In England, more than three hundred thousand people are diagnosed with cancer each year. The diagnostic and treatment pathways for multiple cancers have greatly developed over the past decade.
- Trial name
- Tumouroids (NCT03300102)
- Testing
- Questionnaires, interviews and or tissue donation
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- University College, London
Carcinoma, Non-Small-Cell Lung
Efficacy and Safety Study of Afatinib to Treat Lung Cancer Patients
The purpose of this study is to examine the efficacy and safety of using afatinib (BIBW 2992) to treat non-small cell lung cancer patients considered unfit for chemotherapy and have either suspected or confirmed Epidermal Growth…
- Trial name
- TIMELY (NCT01415011)
- Testing
- Afatinib (BIBW 2992)
- Where
- 15 sites in United Kingdom
- Volunteers
- 39 people
- Sponsor
- University College, London
Varicella Zoster, Stroke
Reactivation of Varicella Zoster Virus and Risk of Vascular Disease
The purpose of this study is to investigate whether there is an association between stroke or heart attack and reactivation of varicella zoster virus, measured by antibody levels, using linked data from the Health Survey for…
- Conditions
- Varicella Zoster, Stroke, Transient Ischaemic Attack, Acute Myocardial Infarction
- Trial name
- NCT02559596
- Sponsor
- University College, London
HIV
Peer Delivery of HIV Self Test to Improve Linkage to HIV Prevention
Hypothesis: HIV-Self-Test (HIV-ST) will allow peers or peer-networks to effectively and efficiently link older adolescent girls and young women into HIV prevention and care services.
- Trial name
- NCT03751826
- Testing
- Incentivised network delivery of HIV-ST, Peer navigator delivery of HIV-ST, standard of care
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University College, London