Clinical trials: sponsored by University College, London
Unipolar Major Depressive Disorder
Non-invasive Brain Stimulation and Cognitive Processing in Depression
Depression is a serious mental health problem that affects millions. Depression is usually treated using drugs and/or psychotherapy, but neither approach is successful for everyone, and some people do not respond to either.
- Trial name
- NCT01875419
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Cystic Echincoccosis, Hydatid Disease
MR Assessment of Hepatic Hydatid Disease
Hydatid disease is a major healthcare problem worldwide caused by infection that commonly affects the liver. Treatments for hydatid disease depend on how advanced the disease is and if the infection is active or not.
- Trial name
- NCT03289884
- Testing
- MRI scan (not involving ionising radiation), Ultrasound scan (not involving ionising radiation), Ex vivo MRI scan of cyst fluid sample
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Percutaneous Coronary Intervention
Exploring the Volume-Outcome Relationship for PCI Procedures Undertaken in a UK Context: A NICOR Study
The relationship between annual procedural volume and patient outcome remains a debated issue in the field of interventional medicine.
- Trial name
- NCT02184949
- Testing
- Percutaneous Coronary Intervention, Primary Percutaneous Coronary Intervention
- Where
- United Kingdom
- Volunteers
- 427,467 people
- Sponsor
- University College, London
Glioblastoma
A Randomised Trial Investigating the Additional Benefit of Hydroxychloroquine(HCQ)to Short Course Radiotherapy (SCRT) in Patients Aged 70 Years and Older With High Grade Gliomas (HGG)
There is emerging evidence that hydroxychloroquine (HCQ), a drug used commonly in the prevention/ treatment of malaria, rheumatoid arthritis and lupus erythematosus, may improve survival outcome in a variety of cancers including…
- Trial name
- HCQ (NCT01602588)
- Testing
- Hydroxychloroquine, Radiotherapy
- Where
- 15 sites in United Kingdom
- Volunteers
- 54 people
- Sponsor
- University College, London
Charcot-Marie-Tooth Disease, Type IA
BALTiC Study: A Feasibility Analysis of Home Based BALance Training in People With Charcot-Marie-Tooth Disease
Charcot Marie Tooth (CMT) is the most common inherited neuropathy. It affects the nerves of the hands and feet first, slowly progressing towards the centre of the body.
- Trial name
- BALTiC (NCT02982343)
- Testing
- Falls management plus exercise training, Falls management only
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Aphasia
Listen in: Developing and Testing a Therapy Application for Patients With Speech Comprehension Deficits After Stroke.
The main aim is to develop and test the clinical efficacy of a novel, web based, rehabilitation application. Listen-In will provide an effective speech comprehension training tool that patients with aphasia can use to practice…
- Trial name
- Listen-in (NCT02540889)
- Testing
- Auditory comprehension therapy.
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University College, London
Arthritis, Juvenile Idiopathic, Enthesitis-Related Arthritis, Juvenile
Juvenile Arthritis Quantitative Imaging
This observational study aims to develop and validate quantitative magnetic resonance imaging biomarkers as measures of disease activity in juvenile idiopathic arthritis (JIA).
- Trial name
- JAQI (NCT02684695)
- Testing
- MRI scan (adolescent spine protocol), MRI scan (whole body protocol)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Prostate Neoplasm
PRostate Evaluation for Clinically Important Disease: Sampling Using Image-guidance Or Not?
This evaluates the detection rates of prostate cancer by MRI-targeted prostate biopsy compared to standard 12-core trans-rectal ultrasound guided (TRUS) prostate biopsy.
- Trial name
- PRECISION (NCT02380027)
- Testing
- MRI, MRI-targeted biopsy, TRUS-biopsy
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Male Erectile Disorder, Prostate Cancer
Focal Therapy for Prostate Cancer Using HIFU
RATIONALE: Prospective trials using hemi-ablation with high intensity focused ultrasound (HIFU) (Sonablate 500) have demonstrated feasibility, safety, and encouraging functional outcomes and early cancer control with 90% of men…
- Conditions
- Male Erectile Disorder, Prostate Cancer, Therapy-related Toxicity, Urinary Incontinence
- Trial name
- INDEX (NCT01194648)
- Testing
- questionnaire administration, assessment of therapy complications, high-intensity focused ultrasound ablation
- Where
- United Kingdom
- Volunteers
- 354 people
- Sponsor
- University College, London
Cancer, Cardiovascular Diseases
Development of Photoacoustic Tomography
Cancer is one of the leading causes of death internationally. When planning treatment for most cancers, it is important to know how far it has spread, including whether or not the cancer has spread to the local lymph nodes (LNs)…
- Trial name
- NCT03501823
- Testing
- Photoacoustic tomography
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University College, London
Diagnostic, Chronic Viral Hepatitis B
Sysmex-XN 20 Analyser to Assess Lymphocyte Subsets and Other Haematological Parameters in Chronic/Acute Viral Infections
The XN-20, is a full blood count (FBC) analyser with an extended differential counting and flagging System. The XN-Series' individual channels allow real-time reflex analysis, and uses a two stage process to classify the white…
- Conditions
- Diagnostic, Chronic Viral Hepatitis B, Chronic Hepatitis C, Chronic HIV Infection
- Trial name
- SASA (NCT03495570)
- Testing
- blood draw
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Brain Neoplasms
Improving Surgical Outcomes in Patients With Low Grade Gliomas Using Advanced Pre- and Intra-operative MRI
This aim of this study is to improve the outcomes for patient with gliomas undergoing neurosurgery by maximising the extent of resection whilst minimising neurological morbidity.
- Trial name
- NCT02884947
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University College, London
Breast Neoplasms
Treatment of Primary Breast Cancer Using PDT
Phase I/IIA, open label, non-randomised, single site trial in patients with primary breast cancer.
- Trial name
- NCT02872064
- Testing
- Verteporfin
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Healthy Volunteers, Relative Afferent Pupil Defect
The PUPIL Study - Automated, Quantitative Pupil Assessment Using Binocular OCT
In current, clinical ophthalmology, a range of specialised testing allows comprehensive evaluation of ocular health. These tests have typically evolved over many years to ensure their clinical validity.
- Conditions
- Healthy Volunteers, Relative Afferent Pupil Defect, Pupil Anomaly
- Trial name
- NCT03081468
- Testing
- Binocular OCT prototype, Konan RAPDx
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Medicines Optimisation
Development of the Medicines Optimisation Assessment Tool
The purpose of this study is to develop a prediction-tool, the Medicines Optimisation Assessment Tool (MOAT), to assist hospital pharmacists identify patients at highest risk of preventable medication related problems (MRPs).
- Trial name
- MOAT (NCT02582463)
- Where
- United Kingdom
- Volunteers
- 1,552 people
- Sponsor
- University College, London
Brugada Syndrome
Ripple Mapping for Epicardial Mapping of Brugada Syndrome
Whether a mapping algorithm "Ripple-mapping" is able to rapidly identify the areas of long-duration multicomponent electrograms which constitute the targets for ablation for an automated strategy remains to be assessed.
- Trial name
- NCT03435393
- Testing
- Catheter ablation
- Where
- 3 sites in Brazil, Portugal and 1 more
- Volunteers
- 10 people
- Sponsor
- University College London Hospitals
Anterior Cruciate Ligament Injury
Light Load Blood Flow Restriction Training in Anterior Cruciate Ligament Reconstruction Patient Rehabilitation
This study is examining the post-operative rehabilitation of anterior cruciate ligament (ACL) reconstruction patients within the National Health Service (NHS).
- Trial name
- NCT03419169
- Testing
- Light load BFR resistance training, Heavy load resistance training
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Hypokalemic Periodic Paralysis
Bumetanide in Hypokalaemic Periodic Paralysis
This is a randomised, double-blind, placebo-controlled phase II clinical trial with a cross-over design to investigate the efficacy of bumetanide in patients with hypokalemic periodic paralysis (HypoPP).
- Trial name
- NCT02582476
- Testing
- Bumetanide
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Stable Angina, Unstable Angina
Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study
Serum uric acid level is a commonly measured biomarker. The association between serum uric acid level and the risk of developing cardiovascular diseases has been observed in some studies, while others showed controversial…
- Conditions
- Stable Angina, Unstable Angina, Myocardial Infarction, Unheralded Coronary Heart Disease Death
- Trial name
- NCT03425305
- Volunteers
- 180,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Glycogen Storage Disease Type V, McArdle Disease
Sodium Valproate for GSDV
McArdle disease is a metabolic myopathy characterised by the absence of glycogen phosphorylase in skeletal muscle. Sodium Valproate is part of a group of drugs known as histone deacetylase inhibitors, which have a direct effect…
- Trial name
- NCT03112889
- Testing
- Sodium Valproate
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 8 people
- Sponsor
- University College, London