Clinical trials: sponsored by University College, London
Epilepsy
Intermittent Fasting in Refractory Epilepsy
This is an open trial of intermittent fasting in a group of patients with refractory seizures. Patients will continue on the diet for 6 months to assess the impact of the diet on seizure frequency.
- Trial name
- NCT02311023
- Testing
- Intermittent fasting
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College London Hospitals
Dementia in Parkinson's Disease
Nucleus Basalis Deep Brain Stimulation for Thinking & Memory Problems in Parkinson's.
We will perform a pilot study to evaluate the effectiveness of human NBM DBS at improving cognitive deficits in PD patients referred and eligible for conventional DBS treatment for coexisting motor impairments.
- Trial name
- NCT01701544
- Testing
- NBM DBS
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Dementia With Lewy Bodies
Deep Brain Stimulation for Patients With Dementia With Lewy Bodies
This trial aims to collect pilot data to explore whether bilateral deep brain stimulation (DBS) of the Nucleus Basalis of Meynert (NBM) has beneficial effects on memory and thinking impairments among individuals with Dementia…
- Trial name
- NCT02263937
- Testing
- Bilateral Nucleus Basalis Meynert DBS
- Where
- 2 sites in United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Prostate Cancer
Serial mpMRI (Multi Parametric Magnetic Resonance Imaging) Scanning in Prostate Cancer After Androgen Deprivation Therapy and RadioTherapy
The evaluation of the radiological changes in localised or locally advanced prostate cancer after androgen deprivation therapy and external beam radiotherapy using multi-parametric MRI (multi parametric magnetic resonance…
- Trial name
- SMART (NCT02721784)
- Testing
- mpMRI/VERDICT, External Beam Radiotherapy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Dizziness, Vertigo
Proof of Concept Study of EMBalance Decision Support System to Evaluate Balance Disorders
Balance is crucial for an individual's mobility and independence. Human balance is achieved and maintained by a complex set of sensorimotor systems that include sensory input from vision, proprioception and the vestibular system…
- Trial name
- EMBalance (NCT02704819)
- Testing
- Decision Support System (DSS), Specialist Audiovestibular Consultation, DSS Customised Vestibular Physiotherapy
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 200 people
- Sponsor
- University College, London
ST-elevation Myocardial Infarction
Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size
Heart attacks, or myocardial infarcts, are a major cause of death and disability in the UK. Immediate unblocking of the obstructed heart vessel with a balloon catheter and implantation of a mesh scaffold (stent) in heart centers…
- Trial name
- MINIMISE-STEMI (NCT01882179)
- Testing
- Mineralocorticoid receptor antagonist potassium-canrenoate
- Where
- 4 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- University College, London
Spinal Anesthesia, Pregnancy
Ephedrine vs Phenylephrine - ECG Changes
ECG changes during caesarean section are common. Incidence of ST depression on the ECG is up to 81% in some studies. Although this may indicate inadequate oxygen supply to the heart muscle (myocardial ischaemia) many other…
- Trial name
- NCT01243970
- Testing
- Phenylephrine, Ephedrine
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Prostate Cancer
Localising Occult Prostate Cancer Metastases With Advanced Imaging TEchniques
The investigator prospectively compare diagnostic concordance of whole body multi---parametric Magnetic Resonance Imaging (MRI) with current conventional multi---modality reference standard imaging (CT scan, isotope bone scan…
- Trial name
- LOCATE (NCT02935816)
- Testing
- Whole body MRI
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- University College, London
Lymphoma
Whole Body PET-MRI in Paediatric and Adolescent Lymphoma
Children and adolescents with Hodgkin lymphoma currently undergo multiple investigations including a separate PET and MRI scans during their treatment.
- Trial name
- PET/MRI (NCT02935348)
- Testing
- Whole Body MRI
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University College, London
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Auditory Processing Disorder, Central, Stroke
Auditory Rehabilitation in Stroke Patients With Auditory Processing Disorders
This study aimed to evaluate long term benefits in speech reception in noise, after daily 10 week use of an assisting listening device (personal frequency-modulates systems) , in non-aphasic stroke patients with auditory…
- Trial name
- NCT02889107
- Testing
- personal frequency modulated systems
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University College, London
Idiopathic Pulmonary Fibrosis, IPF
The Coagulation Cascade in Idiopathic Pulmonary Fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) is incompletely understood but recurrent epithelial injury occurs which evokes the coagulation cascade.
- Conditions
- Idiopathic Pulmonary Fibrosis, IPF, Interstitial Lung Disease
- Trial name
- NCT02885961
- Testing
- Dabigatran, FDG PET scan
- Volunteers
- 12 people
- Sponsor
- University College, London
Primary Amenorrhoea, Hypothalamic Amenorrhoea
Pubertal Induction in Individuals With Hypogonadism
The investigators wish to explore the variability of uterine, breast and bone outcome markers as surrogates to assess the adequacy of exogenous oestrogen replacement in individuals with hypogonadism.
- Conditions
- Primary Amenorrhoea, Hypothalamic Amenorrhoea, Hypogonadotrophic Hypogonadism, Hypopituitarism
- Trial name
- NCT02871986
- Testing
- Routine transdermal oestrogen patch
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Dementia
Compassion Pilot Intervention Study to Enhanced Integrated Care for People With Severe Memory Problems
The investigators developed the theory-driven 'Compassion Intervention', an integrated, interdisciplinary approach to address existing gaps in end-of-life care for people with advanced dementia.
- Trial name
- NCT02840318
- Testing
- Compassion Intervention
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- University College, London
Prostate Cancer
Cancer Diagnosis by Multiparametric UltraSound of the Prostate
In men who require a prostate biopsy does a multi-parametric ultrasound based diagnostic strategy compared to a multi-parametric MRI based diagnostic strategy lead to similar detection of clinically significant prostate cancer?
- Trial name
- CADMUS (NCT02712684)
- Testing
- multiparametric MRI. Multi-parametric ultrasound
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Healthy
Effects of GABA Modulator AZD7325 on Cutaneous Sensation
GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the human brain. For years, drugs that enhance its effects (e.g., benzodiazepines such as diazepam/Valium) have been used to treat various diseases such as…
- Trial name
- NCT02530580
- Testing
- 20 mg AZD7325
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College, London
Generalised Anxiety Disorder
Trial of Sertraline Versus Cognitive Behaviour Therapy for Generalised Anxiety
Generalised Anxiety Disorder (GAD) is common, causes unpleasant symptoms and impairs people's functioning. It is often chronic and may be accompanied by depression and other anxiety disorders.
- Trial name
- ToSCA (NCT02347033)
- Testing
- Sertraline, Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University College, London
Vision, Low, Child
CREATE - Children Reading With Electronic Assistance To Educate
This pilot randomized controlled trial (RCT) will test the methodology for a full RCT of assistive technologies for children/young people with low vision/blindness.
- Conditions
- Vision, Low, Child, Adolescent Development
- Trial name
- CREATE (NCT02798848)
- Testing
- Tablet computer
- Where
- 3 sites in India, United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Aortic Stenosis
Regression of Myocardial Fibrosis After Aortic Valve Replacement
Aortic stenosis (AS) is the most common valvular heart condition in the United Kingdom and the Western world. Surgery for severe AS prior to symptom onset is controversial.
- Trial name
- RELIEF-AS (NCT02174471)
- Where
- United Kingdom
- Volunteers
- 181 people
- Sponsor
- University College, London
Overactive Bladder, Multiple Sclerosis
Transcutaneous Tibial Nerve Stimulation of Patients With Overactive Bladder (OAB) Syndrome
Tibial nerve stimulation (TNS) has been recognised as a safe and effective treatment for the management of overactive bladder (OAB) symptoms.
- Trial name
- NCT02790307
- Testing
- The Geko
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London