Clinical trials: sponsored by University College, London
Mantle Cell Lymphoma
Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma
This is a phase II, single-arm, open-label, multicentre study of acalabrutinib and rituximab for elderly or frail patients with previously untreated mantle cell lymphoma.
- Trial name
- CARAMEL (NCT05004064)
- Testing
- Acalabrutinib, Rituximab
- Where
- 12 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London
Respiratory Monitoring
Respiratory OBservation Using Ultra-Sensitive nanoTechnology
The Problem - About one in three patients get even more sick while they are in hospital. This often happens because of chest infections, sepsis (very serious infection), or heart problems.
- Trial name
- ROBUST (NCT07650539)
- Testing
- Nanotechnology respiratory monitor
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- University College, London
Bladder Cancer
DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr
DURANCE is a two part, phase Ib/II, multi-centre study to assess the safety and activity of S-488210/S-488211 in combination with durvalumab, in patients with non-muscle invasive bladder cancer (NMIBC).
- Trial name
- DURANCE (NCT04106115)
- Testing
- Durvalumab, S-488210/S-488211
- Where
- 7 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- University College, London
Musculoskeletal Disorders
PRISM: The PRimary Care Individual Social Norms MSK Data Dashboard: a Feasibility Trial
Background: 20 million people in UK have musculoskeletal (MSK) aches and pains. They commonly see their GP about this problem, but practices are so busy that it can mean a long wait for appointments.
- Trial name
- PRISM (NCT07112508)
- Testing
- PRISM dashboard is a data report, THe usual care intervention is a first contact physiotherapy service.
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Epilepsy
Electrical Impedance Tomography of Epilepsy
The purpose of this study is to determine if Electrical Impedance Tomography (EIT) can produce reproducible and accurate images in people with epilepsy compared to existing standards such as MRI, CT or EEG.
- Trial name
- NCT03050931
- Testing
- Electrical Impedance Tomography
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University College, London
Vagus Nerve Diseases, Epilepsy
Electrical Impedance Tomography & Selective Stimulation of Vagus Nerve
Electroceuticals is a new field in which the goal is to treat a wide variety of medical diseases with electrical stimulation of autonomic nerves.
- Conditions
- Vagus Nerve Diseases, Epilepsy, Vagus Nerve Autonomic Disorder
- Trial name
- EITsVNS (NCT05664854)
- Testing
- Nerve cuff electrodes for spatially selective vagus nerve stimulation and electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Acute Lymphoblastic Leukemia
CARPALL: Immunotherapy With CD19+CD22 CAR T-cells for CD19+ and CD22+ Acute Lymphoblastic Leukaemia
This study aims to evaluate the safety, efficacy and duration of response of CD19+CD22 Chimeric Antigen Receptor (CAR) redirected autologous T-cells in children with high risk, relapsed CD19+ and CD22+ acute lymphoblastic…
- Trial name
- NCT02443831
- Testing
- Leukapheresis, Total Body Irradiation (TBI), Lymphodepletion with Fludarabine
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Head and Neck Cancer
Phase I Study of Olaparib Combined With Cisplatin-based Chemoradiotherapy to Treat Locally Advanced Head and Neck Cancer
The phase I trial aims to determine the recommended phase II dose (RP2D) and schedule of olaparib in combination with standard cisplatin-based chemoradiotherapy, in patients with high-risk locally advanced squamous cell carcinoma…
- Trial name
- ORCA-2 (NCT02308072)
- Testing
- Olaparib, Cisplatin, IMRT
- Where
- 3 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
Antiphospholipid Syndrome, Systemic Lupus Erythematosus
RIvaroxaban for Stroke Patients With AntiPhospholipid Syndrome
Rivaroxaban versus warfarin for stroke patients with antiphospholipid syndrome, with or without SLE (RISAPS): a randomised, controlled, open-label, phase IIb, non-inferiority proof of principle trial.
- Conditions
- Antiphospholipid Syndrome, Systemic Lupus Erythematosus, Stroke, Ischemic Stroke
- Trial name
- RISAPS (NCT03684564)
- Testing
- Rivaroxaban, Warfarin
- Where
- 6 sites in United Kingdom
- Volunteers
- 43 people
- Sponsor
- University College, London
Head and Neck Cancer, Squamous Cell Carcinoma
EACH: Evaluating Avelumab in Combination With Cetuximab in Head and Neck Cancer
Head \& neck (H\&N) cancer is the eighth most common cancer in the UK. Advanced H\&N cancer which has come back after treatment or has spread to other parts of the body is incurable and the average life expectancy of these…
- Trial name
- EACH (NCT03494322)
- Testing
- Avelumab, Cetuximab
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
Ovarian Cancer, Fallopian Tube Cancer
Trial of Pembrolizumab Following Weekly Paclitaxel for Platinum-resistant Ovarian, Fallopian Tube or Peritoneal Cancer
The overall aim of the study is to demonstrate a clinically meaningful extension of progression free survival using maintenance pembrolizumab.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- PROMPT (NCT03430700)
- Testing
- Pembrolizumab
- Where
- 4 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Radical Prostatectomy, Erectile Dysfunction Following Radical Prostatectomy
EVERiST: Impact of Image Detected Accessory Pudendal Artery on Erection Recovery After Nerve Sparing Prostatectomy
Prostate cancer is the most common cancer amongst men in the United Kingdom, and two common curative treatments are surgery to remove the prostate (radical prostatectomy) or radiotherapy.
- Conditions
- Radical Prostatectomy, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Due to Arterial Insufficiency, Robotic Radical Prostatectomy
- Trial name
- EVERiST (NCT07597798)
- Testing
- Robotic Radical Prostatectomy, Penile doppler ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Prostate Cancer, Prostate Cancer (Adenocarcinoma)
A Study to Evaluate the Performance of Confocal Microscopy to Detect Positive Margins During Radical Prostatectomy
The goal of this study is to find out whether a new method called "LaserSAFE" can accurately detect cancer at the edge of the prostate (called a positive margin) during prostate surgery.
- Trial name
- LaserSAFE (NCT07541911)
- Testing
- LaserSAFE
- Where
- United Kingdom
- Volunteers
- 693 people
- Sponsor
- University College, London
Stroke
Potential for Recovery of Voluntary Finger Extension After Stroke
Stroke patients with absent voluntary finger extension (VFE) 6-months after stroke are not expected to recover hand function. However, experience from the Queen Square Upper Limb neurorehabilitation service contradicts this view.
- Trial name
- PROVES (NCT07592247)
- Testing
- Neuromuscular Electrical Stimulation and Home Exercise Programme
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Lung Cancer
Analysis of Screen-detected Lung Cancers' Genomic Traits
Prospective, observational cohort study of patients undergoing surgical resection for low dose CT (LDCT) screen-detected lung cancer (detected through the SUMMIT study- ClinicalTrials.gov Identifier: NCT03934866/ lung screening…
- Trial name
- ASCENT (NCT04204499)
- Where
- 2 sites in United Kingdom
- Volunteers
- 526 people
- Sponsor
- University College, London
Non-Tuberculous Mycobacteria Pulmonary Disease, Bronchiectasis
Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD)
Nontuberculous mycobacteria (NTM) are environmental organisms found in soil and water. The majority do not cause human disease. When they do, this is mostly as a chronic lung infection in people with long-term lung problems such…
- Trial name
- NCT07192705
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Metastatic Prostate Cancer
Plasma Analysis for Response Assessment and to DIrect the manaGement of Metastatic Prostate Cancer
This research study is looking into plasma tumour deoxyribonucleic acid (ptDNA), a substance that is shed by cancer cells and can be detected in blood samples.
- Trial name
- PARADIGM (NCT04067713)
- Where
- 16 sites in United Kingdom
- Volunteers
- 192 people
- Sponsor
- University College, London
Adolescent Idiopathic Scoliosis (AIS)
Detection of Scoliosis
This study aims to evaluate whether plantar pressure data collected during standing and walking can be used with machine learning to support early detection of scoliosis in young people.
- Trial name
- NCT07581015
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College, London
Loneliness
INcreasing Adolescent Social and Community SupporT - Full Trial
Background: Social Prescribing is a mechanism of connecting patients with non-medical forms of support within the community and has been shown to improve loneliness. Yet update from young people has been lower than for adults.
- Trial name
- INACT (NCT07154225)
- Testing
- Social Prescribing, Signposting
- Where
- United Kingdom
- Volunteers
- 215 people
- Sponsor
- University College, London