Clinical trials: completed, sponsored by University College, London
Polyps, Adenoma Colon
CADDIE Trial - Computer Aided Diagnosis and Detection for Intelligent Endoscopy
Background: Colonoscopy is accepted to be the gold standard for screening of colorectal cancer (CRC). Most CRCs develop from adenomatous polyps, with colonoscopy accepted to be the gold standard for screening of CRC.
- Conditions
- Polyps, Adenoma Colon, Colorectal Polyp, Colon Polyp
- Trial name
- CADDIE (NCT04325815)
- Testing
- CADDIE- Computer Aided (AI) Device used in Endoscopy
- Where
- United Kingdom
- Volunteers
- 739 people
- Sponsor
- University College, London
Fluid Overload, Congestive Heart Failure
THIRST Alert Trial
The aim of this feasibility study is to determine whether an alert embedded within the electronic health record (EHR) causes clinicians to enrol patients into a randomised controlled trial (RCT) comparing oral fluid restriction…
- Trial name
- THIRST (NCT05869656)
- Testing
- Fluid restriction, Free fluids
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London
COVID-19 (Coronavirus Disease 2019), Hypoxia
Nebulised Dornase Alfa for Treatment of COVID-19 (Coronavirus Disease 2019)
An open-label, randomised, Best-Available-Care (BAC) and historic-controlled trial of nebulised dornase alfa [2.5 mg BID (bis in die)] for 7 days in participants with COVID-19 who are admitted to hospital and are at risk of…
- Trial name
- COVASE (NCT04359654)
- Testing
- Dornase Alfa Inhalation Solution [Pulmozyme]
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- University College, London
Prostate Cancer
Study to Evaluate a New Method to Detect Residual Tumours During Surgery for Prostate Cancer Using Confocal Microscopy
Prostate cancer is the most common solid cancer affecting male patients worldwide. When diagnosed early, it can usually be cured with surgery (radical prostatectomy), but this procedure is associated with side effects such as…
- Trial name
- NCT06398470
- Testing
- NeuroSAFE procedure, LaserSAFE procedure
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University College, London
Advanced Cancer
Prognostic Understanding in ESC (ProgESC Study)
This study aims to assess how aware patients with advanced cancer are about their prognosis when they are referred to an Enhanced Supportive Care (ESC) service.
- Trial name
- NCT06067087
- Where
- United Kingdom
- Volunteers
- 91 people
- Sponsor
- University College, London
Anxiety Acute, Anxiety Fear
Paediatric Peri-operative Anxiety: Does the Little Journey App Help?
To evaluate the clinical effectiveness of a virtual reality psychological preparation app at reducing peri-operative anxiety and its associated sequelae in children aged 3-12 years old undergoing ambulatory surgery compared to…
- Conditions
- Anxiety Acute, Anxiety Fear, Peri-operative, Psychological Distress
- Trial name
- NCT03797716
- Testing
- Little Journey app
- Where
- 17 sites in United Kingdom
- Volunteers
- 596 people, healthy volunteers welcome
- Sponsor
- University College, London
Inflammatory Bowel Diseases
Service Development of POCUS in the IBD Clinic
Study to determine whether the use of an ultrasound completed during an inflammatory bowel disease (IBD) clinic will speed up diagnosis, treatment initiation, reduce complications, save money and reduce investigations compared…
- Trial name
- NCT05838196
- Testing
- Point-of-care ultrasound
- Where
- United Kingdom
- Volunteers
- 122 people
- Sponsor
- University College, London
Sleep Disordered Breathing
3D Printing of Positive Airway Pressure (PAP) Therapy Masks: a Single Site Pilot and Feasibility Study
This study is a single site pilot and feasibility study. We propose that 3D printing could be used to create customised masks for patients requiring Positive Airway Pressure (PAP) therapy.
- Trial name
- 3DPiPPIn (NCT04179123)
- Testing
- Customised PAP interfaces
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College, London
Waldenstrom Macroglobulinemia
Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia
This study is for patients who have previously been treated for Waldenström's macroglobulinaemia (WM) and their disease has either not responded (known as refractory disease) or has returned (known as relapsed disease).
- Trial name
- PembroWM (NCT03630042)
- Testing
- Pembrolizumab, Rituximab
- Where
- 9 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- University College, London
Depression, Anxiety
Mood Awareness Psychotherapy Support
The aim of this single arm feasibility trial is to examine an internet delivered, self-help program for depression and anxiety, based on psychodynamic therapy.
- Trial name
- MAPS (NCT06133582)
- Testing
- Internet Based Psychodynamic Psychotherapy
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University College, London
Secondary Progressive Multiple Sclerosis (SPMS)
Multiple Sclerosis-Simvastatin Trial 2
Multiple Sclerosis (MS) is a progressive neurological disorder of the brain and spinal cord. It affects approximately 120,000 people in the United Kingdom and 2.5 million people globally.
- Trial name
- MS-STAT2 (NCT03387670)
- Testing
- Simvastatin
- Where
- 31 sites in United Kingdom
- Volunteers
- 964 people
- Sponsor
- University College, London
COVID19
Study of Plasma Exchange in Severe COVID-19
The rationale in severe COVID19 infection is to undertake PEX to aid reduction of the hyperinflammation and reduce the morbidity and mortality to the lungs, but also systemically, such as the heart, kidneys and brain.
- Trial name
- COVIPLEX (NCT04623255)
- Testing
- OCTAPLAS
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London
Lymphoma
Rituximab in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Follicular Non-Hodgkin's Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00112931
- Testing
- rituximab, No treatment
- Where
- 72 sites in Australia, New Zealand and 1 more
- Volunteers
- 462 people
- Sponsor
- University College, London
Lymphoma
Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma
RATIONALE: Imaging procedures, such as fludeoxyglucose F 18 (FDG)-PET/CT scan, done before, during, and after chemotherapy may help doctors assess a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00678327
- Testing
- bleomycin sulfate, filgrastim, pegfilgrastim
- Where
- United Kingdom
- Volunteers
- 1,202 people
- Sponsor
- University College, London
Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma
Trial of Haploidentical Stem Cell Transplantation for Haematological Cancers
This trial investigates stem cell transplants from partially mismatched donors in patients with blood and bone marrow cancers. The trial will test two kinds of transplants - a full intensity transplant using a high dose of…
- Conditions
- Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Acute Myeloid Leukaemia, Acute Lymphoblastic Leukaemia
- Trial name
- UK-Haplo (NCT01597219)
- Testing
- Reduced intensity haplodentical stem cell transplant, Myeloablative haploidentical stem cell transplant
- Where
- 12 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- University College, London
Sedentary, Overweight
The Efficacy of Chlorella Supplementation on Health and Performance Following a 12-week Training Programme
Algae are an emerging functional food source that are gaining traction and popularity in biopharmaceutical, nutraceutical, and biotechnology industries.
- Trial name
- NCT05639634
- Testing
- Chlorella supplementation, 12 week cardiovascular training programme
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University College, London
Primary Aldosteronism
Short- and Long-term Outcomes of Adrenalectomy for Primary Aldosteronism
The proposed study is this. Short- and long-term outcomes of adrenalectomy for Primary Aldosteronism (PA) in a single centre. PA is a relatively common problem and considers as the commonest cause of secondary hypertension and…
- Trial name
- NCT06192810
- Testing
- Laparoscopic/open adrenalectomy
- Volunteers
- 84 people
- Sponsor
- University College London Hospitals
Duchenne Muscular Dystrophy
Outcome Measures in Duchenne Muscular Dystrophy: A Natural History Study
Novel emerging therapies for Duchenne Muscular Dystrophy (DMD) require a deeper understanding of DMD natural history. This study aim to assess the natural history of DMD through a composite assessment tool capable of capturing…
- Trial name
- NCT02780492
- Testing
- Set of assessment tools
- Where
- 5 sites in France, Netherlands and 1 more
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University College, London
Bladder Cancer
Detecting Bladder Cancer Using the UroMark Test.
DETECT I is a prospective multicentre observational diagnostic study to assess the performance of the UroMark assay to rule out bladder cancer in patients with haematuria.
- Trial name
- DETECT I (NCT02676180)
- Testing
- Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 3,700 people
- Sponsor
- University College, London
Bladder Cancer
To Detect the Sensitivity of the UroMark Assay
This is a prospective multicentre observational study to assess the sensitivity of the UroMark assay to detect bladder cancer in participants with new or recurrent disease.
- Trial name
- DETECT II (NCT02781428)
- Where
- 19 sites in United Kingdom
- Volunteers
- 1,643 people
- Sponsor
- University College, London