Clinical trials: sponsored by University College, London
Language Difficulties in British Sign Language
Language Therapy in British Sign Language
In the United Kingdom, the language of the Deaf community is British Sign Language (BSL). A small proportion of Deaf young people who use BSL as their first or dominant language have specific language difficulties and would…
- Trial name
- NCT02579668
- Testing
- Language Therapy
- Volunteers
- 29 people
- Sponsor
- University College, London
Systemic Sclerosis
CSL Behring Sclero XIII
Many patients with Scleroderma (Systemic sclerosis) experience damage to blood vessels, mainly to the small arteries. A common manifestation of this is Raynaud's phenomenon (fingers or toes turning white then blue in the cold)…
- Trial name
- NCT02551042
- Testing
- Fibrogammin®P, coagulation factor XIII concentrate (Human), 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University College, London
Glaucoma, Ocular Hypertension
A Phase I Clinical Trial of DARC
Glaucoma is a major cause of irreversible blindness worldwide, caused by retinal nerve cell (RGC) death. This is currently identified only after significant vision loss has already occurred with an early event in, and a potential…
- Conditions
- Glaucoma, Ocular Hypertension, Glaucoma, Suspect
- Trial name
- NCT02394613
- Testing
- ANX776
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University College, London
Challenging Behaviour
Clinical and Cost Effectiveness of Positive Behaviour Support: a Trial
Many people with intellectual disability have challenging behaviour which often has serious consequences such as the prescription of long term medication, in-patient admissions and disruption of normal daily activities.
- Trial name
- PBS (NCT01680276)
- Testing
- PBS based staff training, Treatment as Usual
- Where
- 3 sites in United Kingdom
- Volunteers
- 246 people
- Sponsor
- University College, London
Familial Hypercholesterolemia, Cardiac Event
Detection of Familial Hypercholesterolaemia in Cardiovascular Disease Registry
Familial hypercholesterolaemia (FH) is an autosomal dominant somatic mutation commonly located on the LDL-receptor, APOB, and PCKS9 gene.
- Conditions
- Familial Hypercholesterolemia, Cardiac Event, Percutaneous Coronary Intervention
- Trial name
- NCT02778646
- Volunteers
- 1,622,948 people
- Sponsor
- University College, London
Conversion Disorder
Feasibility Study of Physiotherapy for Functional Motor Symptoms
The aim of this study is to develop and assess the feasibility of a physiotherapy intervention for people with functional motor symptoms (also known as psychogenic neurological symptoms and conversion disorder).
- Trial name
- NCT02275000
- Testing
- 5 Day Physiotherapy Programme, Physiotherapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Intestinal Diseases
Citrulline Challenge Study for Healthy Subjects in the United Kingdom
There are many forms of small bowel disease but their direct consequences on small bowel function are often very hard, if not impossible, to establish.
- Trial name
- CHS-UK (NCT02772861)
- Testing
- Amino Acid Supplement - One dose, 3-Methylhistidine
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College, London
Biliary Tract Neoplasms, Cholangiocarcinoma
ABC-04 a Study of Cisplatin, Gemcitabine and Selumetinib in Patients With Advanced Biliary Tract Cancer
The objective of this study is to establish the recommended dose of selumetinib, a novel MEK inhibitor for use in combination with gemcitabine and cisplatin.
- Conditions
- Biliary Tract Neoplasms, Cholangiocarcinoma, Gallbladder Neoplasms
- Trial name
- ABC-04 (NCT01242605)
- Testing
- selumetinib, gemcitabine, cisplatin
- Where
- 3 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University College, London
Achilles Tendinitis, Right Leg, Achilles Tendinitis
Autologous Stem Cells in Achilles Tendinopathy
This study is looking at a new treatment, using the patient's own stem cells (the repair cells of the body), to see whether this can help reduce pain and promote healing of the Achilles tendon, without side effects.
- Conditions
- Achilles Tendinitis, Right Leg, Achilles Tendinitis, Achilles Degeneration, Achilles Tendon Thickening
- Trial name
- ASCAT (NCT02064062)
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Coronary Disease, Cardiovascular Disease
Gender Differences in the Development, Treatment and Prognosis of Coronary Disease: A CALIBER Study
The initial manifestation of symptomatic coronary disease can range from angina (or symptoms of angina), unheralded acute coronary syndrome (ACS), or unheralded coronary death.
- Trial name
- NCT01164371
- Volunteers
- 1,758,584 people
- Sponsor
- University College, London
Asthma
Potential Benefits of Black Seed Oil Supplementation on Asthma Inflammation and Outcomes
Traditionally, Black Seed (Nigella sativa) is a well-known food supplement and herbal product that has a wide range of medical claims (including asthma) that originate from different historical backgrounds.
- Trial name
- NCT02407262
- Testing
- Black seed oil
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- University College, London
Acute Coronary Syndrome
Variation Between Hospitals in Short-term Mortality After Acute Coronary Syndromes: A CALIBER Study
We seek to investigate whether hospitals in England and Wales vary in their rate of mortality following admission for heart attack or unstable angina, the extent of such variation, whether discharge diagnosis affects the extent…
- Trial name
- NCT01111071
- Where
- United Kingdom
- Volunteers
- 316,648 people
- Sponsor
- University College, London
Motility Disorder of Intestine
Magnetic Resonance Imaging Assessment of Small Bowel Motility
This project involves the development, validation and application of a novel test using MRI to assess gastrointestinal motility a vital process that mixes the contents of our digestive tract.
- Trial name
- NCT02754869
- Where
- United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University College, London
Phaeochromocytoma, Paraganglioma
Phase I Trial of Vandetanib Combined With 131I-mIBG to Treat Patients With Advanced Phaeochromocytoma and Paraganglioma
The phase I trial aims to determine the recommended phase II dose (RP2D) of vandetanib in combination with standard radiation therapy, 131I-mIBG, in patients with advanced phaeochromocytoma (phaeo) and paraganglioma (PG) by…
- Trial name
- VIBRaNT (NCT01941849)
- Testing
- Vandetanib, 131I-mIBG
- Where
- 3 sites in United Kingdom
- Sponsor
- University College, London
Critical Illness, Septic Shock
Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation
Each year, 110,000 English/Welsh patients are admitted to Intensive Care Units (ICU). Many face prolonged disability as a result.
- Conditions
- Critical Illness, Septic Shock, Trauma, Organ Failure
- Trial name
- MUSCLE (NCT01106300)
- Where
- 3 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- University College, London
Retinal Degeneration
Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis
The purpose of the study is to determine whether gene therapy is safe and effective for the treatment of severe childhood blindness caused by mutations in RPE65.
- Trial name
- NCT00643747
- Testing
- tgAAG76 (rAAV 2/2.hRPE65p.hRPE65)
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
Gastro-intestinal Pain
Pilot of Mindfulness Therapy for Inpatients With Gastro-intestinal Pain
Research questions/hypotheses 1. Can an individual mindfulness intervention for Gastro Intestinal Failure inpatients reduce pain-related distress, improve quality of life, and increase confidence in pain self-management? 2.
- Trial name
- NCT02222064
- Testing
- Mindfulness
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University College, London
Dementia, Agitation
A Naturalistic Two-year Cohort Study of Agitation and Quality of Life in Care Homes
One third of the population, aged over 65, live and will die with dementia. Half of people with dementia experience symptoms of agitation every month.
- Trial name
- MARQUE2 (NCT02216396)
- Where
- United Kingdom
- Volunteers
- 1,734 people
- Sponsor
- University College, London
Lymphoma, Hodgkin
MELT - MRI Evaluation of Lymphoma Treatment
Patients who are newly diagnosed with Hodgkin's lymphoma will undergo disease staging at diagnosis and initial treatment response assessment.
- Trial name
- MELT (NCT01459224)
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University College, London
Tinnitus
A Comparison of the Benefits of Mindfulness Based Cognitive Therapy, Relaxation Therapy and a Waiting List Control in the Management of Distress in Chronic Tinnitus Patients
The principal hypotheses to be tested is that Mindfulness Based Cognitive Therapy (MBCT) reduces the distressing impact of tinnitus to a significantly greater extent than a waiting list control or relaxation therapy.
- Trial name
- NCT02059447
- Testing
- No treatment waiting period, Mindfulness Based Cognitive Therapy, Relaxation Therapy
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University College London Hospitals