Clinical trials: sponsored by University College, London
Tinnitus
A Comparison of the Benefits of Mindfulness Based Cognitive Therapy, Relaxation Therapy and a Waiting List Control in the Management of Distress in Chronic Tinnitus Patients
The principal hypotheses to be tested is that Mindfulness Based Cognitive Therapy (MBCT) reduces the distressing impact of tinnitus to a significantly greater extent than a waiting list control or relaxation therapy.
- Trial name
- NCT02059447
- Testing
- No treatment waiting period, Mindfulness Based Cognitive Therapy, Relaxation Therapy
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University College London Hospitals
Multimorbidity
Impact of Socioeconomic Inequalities in Transition Between Health, Multimorbidity and Death Amongst Older People
Life expectancy at age 65 in the most deprived fifth of the English population was about 4 years shorter than of the most affluent fifth in 2010. The inverse gradient between mortality and social position is well established.
- Trial name
- NCT02609516
- Testing
- This is not an intervention study
- Where
- United Kingdom
- Volunteers
- 1,300,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Heart Failure
Heart Failure Recorded in Primary Care, Hospital Admissions and National Mortality Registry
The main objectives of this study are i) to assess how heart failure was captured accross different linked electronic health record sources within the CALIBER program and the overlap between primary care, hospital admissions…
- Trial name
- NCT02551016
- Where
- United Kingdom
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Dementia
Dementia Phenotypes in Primary Care, Hospital, and National Mortality Registries
Most patients with dementia in the UK use their local hospitals and general (family) practices throughout their illness. Linked electronic health records from primary care, hospital and death certificates records therefore…
- Trial name
- NCT02549872
- Testing
- This is not an intervention study
- Where
- United Kingdom
- Volunteers
- 51,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Optic Neuritis, Multiple Sclerosis
Neuroprotection With Phenytoin in Optic Neuritis
Optic neuritis is caused by inflammation of the optic nerve and causes loss of vision in the affected eye. It is often associated with multiple sclerosis.
- Trial name
- NCT01451593
- Testing
- Phenytoin
- Where
- 2 sites in United Kingdom
- Volunteers
- 92 people
- Sponsor
- University College, London
Diabetes Mellitus
Sex Differences in the Risk of Cardiovascular Diseases Associated With Diabetes
To evaluate the risk of cardiovascular events associated with medication use for controlling blood glucose, blood pressure and cholesterol levels in men and women with diabetes treated in primary care
- Trial name
- NCT02542774
- Testing
- No intervention is given.
- Where
- United Kingdom
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Healthy
Effects of GABA Modulator AZD7325 on Cortical Excitability
GABA (gamma-aminobutyric acid) is the main inhibitory compound in the human brain. Drugs that enhance its effects by binding on GABA receptors (e.g., benzodiazepines) are used to treat various diseases such as epilepsy, insomnia…
- Trial name
- NCT02135198
- Testing
- 2 mg AZD7325, 10 mg AZD7325
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College, London
Multiple Sclerosis, Recurrent Urinary Tract Infections
D-mannose for the Prevention of UTIs in Multiple Sclerosis
This is a study to explore the feasibility of using D-mannose, a commonly used food supplement, in persons with multiple sclerosis reporting recurrent urinary tract infections.
- Trial name
- NCT02490046
- Testing
- D Mannose
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Familial Hypercholesterolemia
Atherosclerosis in Familial Hypercholesterolemia
Familial hypercholesterolemia (FH) is a common inherited disorder with a frequency of 1 in 500 in the UK. Our aim is compare the carotid and coronary artery atherosclerosis in monogenic FH and polygenic hypercholesterolemia with…
- Trial name
- NCT02489253
- Testing
- CT coronary angiogram and carotid ultrasound
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Osteosarcoma, Spindle Cell Sarcoma of Bone
Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays?
Methotrexate is one of the most effective chemotherapy drugs in the treatment of osteosarcoma and some other types of bone sarcoma which are treated the same way as osteosarcoma.
- Trial name
- NCT02022358
- Testing
- Glucarpidase, Methotrexate, Folinic Acid
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Cervical Cancer, Ovarian Cancer
Developing a Stepped Approach to Improving Sexual Function aFteR Treatment fOr gyNaecological Cancer
Women affected by gynaecologic cancers are often not aware of sexual consequences of cancer and its treatment. Most do not receive appropriate advice or help to recover sexual function, and the impact on their sexuality may be…
- Conditions
- Cervical Cancer, Ovarian Cancer, Uterine Cancer, Vaginal Cancer
- Trial name
- SAFFRON (NCT02458001)
- Testing
- SAFFRON stepped care
- Volunteers
- 100 people
- Sponsor
- University College, London
Coronary Heart Disease
Effect of Remote Ischaemic Preconditioning on Clinical Outcomes in CABG Surgery
Coronary heart disease (CHD) is the leading cause of death in the UK, accounting for 124,000 deaths (2006) and costing the UK economy over £7.9 billion a year.
- Trial name
- ERICCA (NCT01247545)
- Testing
- Remote ischaemic preconditioning, Control
- Where
- 28 sites in United Kingdom
- Volunteers
- 1,612 people
- Sponsor
- University College, London
Asthma
Breathing and Relaxation Exercises for Asthma: a Randomised Controlled Trial
All patients on the GP asthma database in one practice were invited for an asthma physical-therapy assessment, at baseline. Volunteers satisfying the inclusion criteria ie - aged between 16 and 70, able to understand, read and…
- Trial name
- NCT00400270
- Testing
- Breathing and relaxation exercises: the Papworth Method
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- University College London Hospitals
Type 2 Diabetes, Hyperlipidemias
The Medicines Advice Service Evaluation
The purpose of this study is to find out whether talking to a pharmacist on the telephone can help to support people taking medicine for a long-term condition.
- Trial name
- NCT01864239
- Testing
- Medicines Advice Service
- Where
- United Kingdom
- Volunteers
- 677 people
- Sponsor
- University College, London
Leukaemia, Lymphoma
Myloablative Cord Blood Transplant in Haematological Malignancies (MAC UCBT)
This trial is looking at using umbilical cord blood from unrelated donors after high dose chemotherapy. It is for people who have cancer of the bone marrow or lymphatic system including leukaemia and lymphoma, or a blood disorder…
- Conditions
- Leukaemia, Lymphoma, Other Haematological Diseases
- Trial name
- MAC UCBT (NCT02310997)
- Testing
- Umbilical Cord Blood Transplant, Cyclophosphamide, Total body irradiation
- Where
- 12 sites in United Kingdom
- Volunteers
- 11 people
- Sponsor
- University College, London
Ovarian Cancer, Fallopian Tube Cancer
Saracatinib and Paclitaxel in Platinum-resistant Ovarian Cancer
The purpose of this study is to investigate whether the addition of the Src inhibitor saracatinib (AZD0530) to weekly paclitaxel improves efficacy, compared with paclitaxel plus placebo, in patients with relapsed…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- SaPPrOC (NCT01196741)
- Testing
- Paclitaxel, Saracatinib
- Where
- 12 sites in United Kingdom
- Volunteers
- 107 people
- Sponsor
- University College, London
Heart Failure
Role of Cardiac Computed Tomography in Optimising Response to Cardiac Resynchronisation Therapy
The purpose of this study is to determine if detailed scanning of the heart before biventricular device insertion will improve outcomes for heart failure patients.
- Trial name
- NCT02434159
- Testing
- Heart scan
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Coronary Heart Disease
Impact of Motivational Interviews Within Pharmacy Care Upon Adherence to Cardiovascular Medicines
Introduction: In the United Kingdom(UK), about 838,000 men and 394,000 women have had a myocardial infarction (MI) and will need secondary prevention medications.
- Trial name
- Pharmacycare (NCT01920009)
- Testing
- Pharmacist counselling session with a motivational interview
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Urinary Retention, Fowler's Syndrome
Botulinum Toxin A Injections in Patients With Fowler's Syndrome
Hypothesis / aims of study Urinary retention is uncommon in young women, and one cause is a primary disorder of urethral sphincter relaxation, characterised by an elevated urethral pressure profile and specific findings in the…
- Trial name
- NCT02428881
- Testing
- onabotulinumtoxinA
- Volunteers
- 10 people
- Sponsor
- University College, London
Hypertrophic Cardiomyopathy
Morbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study
The aim of this project is to study the association of a number of demographic and cardiovascular risk factors with death, health care utilisation and systemic embolisation by examining the clinical evolution of hypertrophic…
- Trial name
- HCM (NCT02424994)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 12,464 people, healthy volunteers welcome
- Sponsor
- University College, London