Clinical trials: sponsored by University College, London
Bladder Cancer
Trial to Compare Robotically Assisted Radical Cystectomy With Open Radical Cystectomy
This is a prospective multicentre randomised controlled trial comparing the outcomes from Intracorporeal RARC (iRARC) with open radical cystectomy (ORC) in patients with bladder cancer.
- Trial name
- iROC (NCT03049410)
- Testing
- Intracorporeal Robot Assisted Radical Cystectomy, Open Radical Cystectomy
- Where
- 8 sites in United Kingdom
- Volunteers
- 339 people
- Sponsor
- University College, London
Metastatic Castration-resistant Prostate Cancer, Metastatic Prostate Cancer
ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium
Advanced metastatic castration-resistant prostate cancer is a medical condition for which additional effective and tolerable treatments are urgently needed in order to improve patient outcomes and quality of life.
- Conditions
- Metastatic Castration-resistant Prostate Cancer, Metastatic Prostate Cancer, Prostate Cancer
- Trial name
- ACT-RESoLUTE (NCT07414940)
- Testing
- Actinium (225Ac) rhPSMA-10.1
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Thyroid Cancer, Thyroid Neoplasms
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
IoN is a phase II/III trial that will look to ascertain whether or not radio-iodine ablation is necessary for low risk differentiated thyroid cancer patients.
- Trial name
- IoN (NCT01398085)
- Testing
- I131 1.1 GBq, No Radioactive iodine (No-RAI) ablation
- Where
- 36 sites in United Kingdom
- Volunteers
- 504 people
- Sponsor
- University College, London
Decompensated Cirrhosis
CirrhoCare- Using Smart-phone Technology to Enhance Care and Access to Treatment for Cirrhosis
The CirrhoCare trial is a multi-centre, open label randomised controlled trial in patients with decompensated cirrhosis. The trial aims to investigate the clinical and cost-effectiveness of CirrhoCare digital home monitoring and…
- Trial name
- CirrhoCare (NCT06223893)
- Testing
- CirrhoCare management system
- Where
- 15 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University College, London
Menopause
Group Compassionate Mind Training for Adults Experiencing the Menopause Transition
Menopause transition occurs naturally for women aged 45-55. In addition to the hormone changes, there are often changes in other areas of life including low mood, anxiety, 'brain fog' and embarrassment.
- Trial name
- NCT06462157
- Testing
- Compassionate Mind Training
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University College, London
Non-small Cell Lung Cancer
Stereotactic Ablative Radiotherapy for Oligometastatic Non-small Cell Lung Cancer
The trial will assess the addition of stereotactic ablative radiotherapy (SABR) to standard anti-cancer therapy (SACT) in patients with oligometastatic non-small cell lung cancer.
- Trial name
- SARON (NCT02417662)
- Testing
- Radical Radiotherapy (Conventional RT and SABR), Non-investigational SACT
- Where
- 19 sites in United Kingdom
- Volunteers
- 140 people
- Sponsor
- University College, London
Parkinson's Disease
Exenatide Once Weekly Over 2 Years as a Potential Disease Modifying Treatment for Parkinson's Disease
This study is a clinical trial in patients with Parkinson's disease (PD), of a drug called exenatide, which is already licensed for the treatment of patients with type 2 diabetes.
- Trial name
- Exenatide-PD3 (NCT04232969)
- Testing
- Exenatide extended release 2mg (Bydureon)
- Where
- United Kingdom
- Volunteers
- 194 people
- Sponsor
- University College, London
Retinal Detachment Rhegmatogenous, Proliferative Vitreoretinopathy
Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment
Disease or general study area: Uncomplicated rhegmatogenous retinal detachment (RRD) and risk of proliferative vittroretinopathy (PVR) Purpose and nature of the study: 1.
- Conditions
- Retinal Detachment Rhegmatogenous, Proliferative Vitreoretinopathy, Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
- Trial name
- Cohort-NHS (NCT07386678)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Stress Incontinence Female, Urodynamic Exam
Impact of CMG vs VCMG in Recurrent Stress Incontinence- A Pilot Study
To asses feasibility of a prospective randomised trial comparing the outcomes of surgery for recurrent urinary incontinence after video-urodynamic(VCMG)and urodynamic(UDS)investigations.
- Conditions
- Stress Incontinence Female, Urodynamic Exam, Urodynamic Stress Incontinence
- Trial name
- NCT07542080
- Testing
- urodynamic testing, videourodynamic testing
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Pituitary Adenoma
AI in Endoscopic Transsphenoidal Surgery
This study focuses on bringing artificial intelligence into the operating room to assist with pituitary tumour surgeries performed through the nose.
- Trial name
- NCT07568366
- Testing
- Live intra-op AI analysis of endoscopic video feed, with output displayed on supplementary monitor
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Posttraumatic Stress Disorder (PTSD), Insomnia
Yoga Nidra for Insomnia and Posttraumatic Stress Symptoms
This randomized feasibility study is designed to investigate the feasibility of recruitment and delivery of two variations (brief; full) of a virtual Integrative Restoration (iRest) yoga nidra meditation intervention in stressor…
- Conditions
- Posttraumatic Stress Disorder (PTSD), Insomnia, Stressor, Psychological, Psychological Trauma
- Trial name
- NCT06888336
- Testing
- Yoga nidra (full), Yoga nidra (brief)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Non-small Cell Lung Cancer
Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity
DARWIN II is a multi-arm non-randomised phase II trial, Eligible patient will be those who relapse with NSCLC (clinical trials.gov ref. NCT02183883). .
- Trial name
- DARWINII (NCT02314481)
- Testing
- MPDL3280A, Vemurafenib, Alectinib
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Atrial Fibrillation (AF)
Cryoballoon/Radiofrequency/Pulsed Field Ablation of Atrial Fibrillation Versus Medical Treatment for Heart
Atrial fibrillation (AF) is a common heart rhythm disorder that causes an irregular heart beat and is a cause of heart failure (HF).
- Trial name
- CRAAFT-HF (NCT06505798)
- Testing
- Catheter Ablation
- Where
- 24 sites in Canada, United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- University College, London
Non-small Cell Lung Cancer
TRAcking Non-small Cell Lung Cancer Evolution Through Therapy (Rx)
To study the NSCLC evolutionary genomic landscape between primary and metastatic sites and the dynamics of intratumour heterogeneity over time combined with detailed clinical, histopathological and cancer phenotypic annotation…
- Trial name
- TRACERx (NCT01888601)
- Where
- 18 sites in United Kingdom
- Volunteers
- 814 people
- Sponsor
- University College, London
Parkinson's Disease (PD)
Mental Health Support for People Affected by Parkinson's
In addition to increasingly severe physical symptoms, Parkinson's can cause distressing mental health issues. These include anxiety, depression, and memory and thinking problems, caused by a combination of biological and…
- Trial name
- NCT06992869
- Testing
- Group-based psychological therapy
- Where
- United Kingdom
- Volunteers
- 138 people
- Sponsor
- University College, London
Huntington's Disease
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable…
- Trial name
- HDClarity (NCT02855476)
- Where
- 40 sites in United States, Canada and 8 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Neuroblastoma
Multi-modular Chimeric Antigen Receptor Targeting GD2 in Neuroblastoma
MAGNETO is a single-centre, non-randomised, open label Phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in children and teenagers aged 1-16 years with relapsed or refractory neuroblastoma.
- Trial name
- MAGNETO (NCT05990751)
- Testing
- GD2 CAR T cells
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University College, London
HIV Prevention, Contraceptive Usage
Peer-led Service Delivery Model for Pregnant and Lactating Adolescent Girls and Young Women in Zimbabwe
This is a pilot cluster-randomized control trial co-led by Dr. Valentina Cambiano, Associate Professor of Epidemiology at University College London, UK and Professor Euphemia Sibanda, Research Director at the Centre for Sexual…
- Conditions
- HIV Prevention, Contraceptive Usage, Adherence, Medication
- Trial name
- Ontanga (NCT07546344)
- Testing
- Peers who are stars
- Where
- 3 sites in Zimbabwe
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College, London
Aphasia Following Cerebral Infarction
Intensive Comprehensive Aphasia Programme for People With Post-Stroke Aphasia
Research question Does participation in an Intensive Comprehensive Aphasia Programme produce a meaningful change in the communication of people with aphasia, their quality of life and that of their carers? Background Aphasia is a…
- Trial name
- RCT of an ICAP (NCT07386652)
- Testing
- ICAP, Standard Care (in control arm)
- Where
- United Kingdom
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University College, London
Glioblastoma, Gliosarcoma, Adult
A Study Assessing if it is Safe and Possible to Treat Brain Cancer Patients With Immunotherapy Before They Receive the Standard Treatment.
WinGlio is a phase I study investigating neoadjuvant (before surgery) ipilimumab ( a type of immunotherapy drug) in patients with newly diagnosed glioblastoma (a form of brain cancer).
- Conditions
- Glioblastoma, Gliosarcoma, Adult, Glioblastoma - Category
- Trial name
- WinGlio-ipi (NCT07134842)
- Testing
- Ipilimumab (3 mg/kg)
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London