Clinical trials: open to volunteers, sponsored by University College, London
Small Bowel Disease, Gastrointestinal Diseases
Anonymous Data Sharing for Small Bowel
Crohn's disease is characterised by an abnormal immunological response within the bowel wall leading to abnormal wall thickening, stricturing (narrowing), fistulation (abnormal connections) to adjacent organs and strictures…
- Trial name
- NCT06868875
- Where
- United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Mental Health, Financial Wellbeing
Healthier Wealthier Families In East London: HWFinEL
The financial condition children live in when they are young can affect their health, not only in their childhood but also throughout their lives. The cost-of-living crisis means many families are 'going without' the basics.
- Trial name
- HWFinEL (NCT06871137)
- Testing
- Welfare Benefits Advice (WBA), Usual care
- Volunteers
- 1,153 people
- Sponsor
- University College, London
People with Terminal Illness
Mapping Financial Support for the Terminally Ill
People living with terminal illness (an illness that is not curable and likely to lead to death) are often unable to work and experience increased costs associated with their health, such as caring costs, needing to purchase aids…
- Trial name
- NCT06793631
- Testing
- Participants will be interviewed qualitatively about experience of providing/receiving financial support for living costs
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College, London
Crohn Disease
Diagnostic Concordance of MR Enterography and Ultrasound for Treatment Response Assessment in Crohn's Disease (MANTRA)
Crohn's disease is a lifelong condition resulting in inflammation of the bowel. Treatment with powerful drugs aim to reduce inflammation by suppressing the immune system.
- Trial name
- NCT06800326
- Testing
- Ultrasound, MRE Scan
- Where
- United Kingdom
- Volunteers
- 155 people
- Sponsor
- University College, London
Depression - Major Depressive Disorder, Depression Anxiety Disorder
Evaluating the Effectiveness and Acceptability of a GPT-4o and RAG-Based Voice Chatbot for Depression Screening Using PHQ-9
This study aims to assess the feasibility and acceptability of a voice-based chatbot, powered by GPT-4o and Retrieval-Augmented Generation (RAG), for conducting depression screening using the Patient Health Questionnaire-9…
- Trial name
- GPT4-RAG-PHQ (NCT06801925)
- Testing
- GPT-4o and RAG Voice Chatbot for PHQ-9 Screening
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Myopia
Red Light Childhood Myopia Proof-of-concept
In this project the research team will begin to find out whether shining a red LED light at the eyes can slow down the worsening of short-sightedness in children.
- Trial name
- NCT06771258
- Testing
- Red Light (PDT)
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Neurological Diseases or Conditions
Measuring Single Neuron Activity in the Brain
The SUNAN (Single Unit Neurophysiological Architecture of the Neocortex) study aims to understand how individual brain cells called neurons interact and communicate, and how the neurons can be affected in neurological disease.
- Trial name
- SUNAN (NCT06763471)
- Testing
- Neuropixels recording intraoperatively during planned neurosurgery
- Volunteers
- 50 people
- Sponsor
- University College, London
Large B-cell Lymphoma
A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab As a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma
The PORTAL study will test a new combination of drugs (glofitamab, polatuzumab vedotin and obinutuzumab) in patients with large B-cell lymphoma (LBCL) that has come back (relapsed) or not responded to previous treatment.
- Trial name
- PORTAL (NCT06071871)
- Testing
- Glofitamab, Polatuzumab vedotin, Obinutuzumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 99 people
- Sponsor
- University College, London
Hemophilia B, Severe, Hemophilia A, Severe
Liver Biopsy In Haemophilia Gene Therapy
To perform a liver biopsy in haemophilia A and B patients with endogenous FVIII:C/FIX:C expression at >1% any time after gene transfer following AAV mediated gene transfer.
- Trial name
- NCT04817462
- Testing
- Liver biopsy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Obsessive-Compulsive Disorder
Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure
The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy. To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order…
- Trial name
- ERP in Silico (NCT05520398)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University College, London
Polyps, Adenoma Colon
Early DiAgnosis Real-Time Healthcare System for CANcer Trial
The purpose of the study is to assess whether the AI characterisation system of the CADDIE device improves the endoscopists accuracy in the optical diagnosis of diminutive colorectal polyps in the bowel during colonoscopy.
- Conditions
- Polyps, Adenoma Colon, Colorectal Polyp, Colon Polyp
- Trial name
- EARTHSCAN (NCT05064124)
- Testing
- CADDIE - Computer Aided Detection and Diagnosis for Intelligent Endoscopy
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University College, London
Healthy
Development of Novel MR Techniques Using Volunteer Participants
Using magnetic resonance (MR) imaging or spectroscopy as part of clinical research typically involves developing new MR protocols.
- Trial name
- NCT05943249
- Testing
- magnetic resonance
- Where
- United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Hepatocellular Carcinoma
Perioperative Pembrolizumab and Lenvatinib in Resectable Hepatocellular Carcinoma (HCC)
This is a multicentre randomised 3-arm phase II clinical trial in patients with resectable Hepatocellular Carcinoma (HCC). Sixty patients will be randomized 1:1:1 to 6 weeks of pre-operative therapy with: pembrolizumab…
- Trial name
- PRIMER-1 (NCT05185739)
- Testing
- Pembrolizumab, Lenvatinib, Pembrolizumab and Lenvatinib
- Where
- 11 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Duchenne Muscular Dystrophy
The U.K. NorthStar Clinical Network
The goal of this natural history study is to capture the natural history of Duchenne Muscular Dystrophy (DMD) in children and adults in the United Kingdom. Children and adults with DMD will be invited to join.
- Trial name
- NS (NCT06711692)
- Where
- 26 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Lung Cancer
Assessment of Novel Biomarkers in Participants Undergoing Targeted Lung Health Checks
Low-dose CT (LDCT) screening for lung cancer (LCS) has been shown to reduce lung cancer specific mortality in multiple randomised controlled trials.
- Trial name
- ALPINE (NCT05902559)
- Where
- United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- University College, London
HIV
Clinical Trial to Evaluate the Effects of Letermovir Prophylaxis on T-cell Immune Activation in Participants With Treated HIV-1 Infection
People living with HIV (PLWH), even with an undetectable viral load (VL) on antiretroviral treatment (ART), develop health conditions, such as heart disease, diabetes, various cancers, and conditions that can affect the brain…
- Trial name
- PROACTIV (NCT06626555)
- Testing
- Letermovir
- Volunteers
- 36 people
- Sponsor
- University College, London
Oropharyngeal Cancer
Lymphatic Mapping Of Oropharyngeal Cancer
A multi-centre validation study to evaluate whether a new imaging and surgical protocol would work as well as the current gold standard in identifying sentinel nodes in patients with oropharyngeal cancer.
- Trial name
- LOOC (NCT04498221)
- Testing
- Imaging procedure, Surgical procedure
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- University College, London
Myelomeningocele, Brain Malformation
The Role of CSF in Chiari II Brain Malformation
Spina bifida, particularly its most severe form known as open spina bifida (myelomeningocele), is a significant congenital disorder that results in profound neurological impairments, including Chiari II malformation.
- Conditions
- Myelomeningocele, Brain Malformation, Chiari Malformation Type 2
- Trial name
- NCT06560788
- Testing
- collection of cerebrospinal fluid
- Volunteers
- 18 people
- Sponsor
- University College, London
Osteosarcoma
ICONIC: Improving Outcomes Through Collaboration in OsteosarComa
There has been little improvement in outcome for patients with osteosarcoma (OS) over the last 20 years. There have been only a few clinical trials of new treatments and no major new therapies introduced recently.
- Trial name
- ICONIC (NCT04132895)
- Testing
- observational only, no interventions are prescribed in protocol.
- Where
- 22 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University College, London
Heart Failure With Reduced Ejection Fraction
VITAL - the Heart Failure With Reduced Ejection Fraction Sub-study
Heart failure affects over 1 million people in the United Kingdom. Approximately 50% have heart failure with reduced ejection fraction (HFrEF), a condition where the heart muscle does not contract properly.
- Trial name
- NCT06534151
- Testing
- CRT implantation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London