Clinical trials: sponsored by University College, London
Prostate Cancer
Study to Evaluate a New Method to Detect Residual Tumours During Surgery for Prostate Cancer Using Confocal Microscopy
Prostate cancer is the most common solid cancer affecting male patients worldwide. When diagnosed early, it can usually be cured with surgery (radical prostatectomy), but this procedure is associated with side effects such as…
- Trial name
- NCT06398470
- Testing
- NeuroSAFE procedure, LaserSAFE procedure
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University College, London
Neurological Diseases or Conditions
Measuring Single Neuron Activity in the Brain
The SUNAN (Single Unit Neurophysiological Architecture of the Neocortex) study aims to understand how individual brain cells called neurons interact and communicate, and how the neurons can be affected in neurological disease.
- Trial name
- SUNAN (NCT06763471)
- Testing
- Neuropixels recording intraoperatively during planned neurosurgery
- Volunteers
- 50 people
- Sponsor
- University College, London
Advanced Cancer
Prognostic Understanding in ESC (ProgESC Study)
This study aims to assess how aware patients with advanced cancer are about their prognosis when they are referred to an Enhanced Supportive Care (ESC) service.
- Trial name
- NCT06067087
- Where
- United Kingdom
- Volunteers
- 91 people
- Sponsor
- University College, London
Anxiety Acute, Anxiety Fear
Paediatric Peri-operative Anxiety: Does the Little Journey App Help?
To evaluate the clinical effectiveness of a virtual reality psychological preparation app at reducing peri-operative anxiety and its associated sequelae in children aged 3-12 years old undergoing ambulatory surgery compared to…
- Conditions
- Anxiety Acute, Anxiety Fear, Peri-operative, Psychological Distress
- Trial name
- NCT03797716
- Testing
- Little Journey app
- Where
- 17 sites in United Kingdom
- Volunteers
- 596 people, healthy volunteers welcome
- Sponsor
- University College, London
Large B-cell Lymphoma
A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab As a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma
The PORTAL study will test a new combination of drugs (glofitamab, polatuzumab vedotin and obinutuzumab) in patients with large B-cell lymphoma (LBCL) that has come back (relapsed) or not responded to previous treatment.
- Trial name
- PORTAL (NCT06071871)
- Testing
- Glofitamab, Polatuzumab vedotin, Obinutuzumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 99 people
- Sponsor
- University College, London
Hemophilia B, Severe, Hemophilia A, Severe
Liver Biopsy In Haemophilia Gene Therapy
To perform a liver biopsy in haemophilia A and B patients with endogenous FVIII:C/FIX:C expression at >1% any time after gene transfer following AAV mediated gene transfer.
- Trial name
- NCT04817462
- Testing
- Liver biopsy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Obsessive-Compulsive Disorder
Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure
The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy. To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order…
- Trial name
- ERP in Silico (NCT05520398)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University College, London
Inflammatory Bowel Diseases
Service Development of POCUS in the IBD Clinic
Study to determine whether the use of an ultrasound completed during an inflammatory bowel disease (IBD) clinic will speed up diagnosis, treatment initiation, reduce complications, save money and reduce investigations compared…
- Trial name
- NCT05838196
- Testing
- Point-of-care ultrasound
- Where
- United Kingdom
- Volunteers
- 122 people
- Sponsor
- University College, London
Children, Only, Surgery
Children's Acute Surgical Abdomen Programme
To describe the type and quality of care being delivered to children (aged 1 - 16 years old) undergoing emergency abdominal surgery in the United Kingdom by measuring baseline compliance against evidence-based recommendations and…
- Conditions
- Children, Only, Surgery, Abdomen, Acute, Perioperative Complication
- Trial name
- CASAP (NCT04602429)
- Where
- United Kingdom
- Volunteers
- 3,100 people
- Sponsor
- University College, London
Polyps, Adenoma Colon
Early DiAgnosis Real-Time Healthcare System for CANcer Trial
The purpose of the study is to assess whether the AI characterisation system of the CADDIE device improves the endoscopists accuracy in the optical diagnosis of diminutive colorectal polyps in the bowel during colonoscopy.
- Conditions
- Polyps, Adenoma Colon, Colorectal Polyp, Colon Polyp
- Trial name
- EARTHSCAN (NCT05064124)
- Testing
- CADDIE - Computer Aided Detection and Diagnosis for Intelligent Endoscopy
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University College, London
Lung Cancer
An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK
The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom.
- Trial name
- OLIVE (NCT06575439)
- Where
- United Kingdom
- Volunteers
- 225 people
- Sponsor
- University College London Hospitals
Healthy
Development of Novel MR Techniques Using Volunteer Participants
Using magnetic resonance (MR) imaging or spectroscopy as part of clinical research typically involves developing new MR protocols.
- Trial name
- NCT05943249
- Testing
- magnetic resonance
- Where
- United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Intracerebral Hemorrhage
Prevention of Hypertensive Injury to the Brain by Intensive Treatment of Blood Pressure After Intracerebral Haemorrhage (PROHIBIT-ICH)
PROHIBIT-ICH will randomise participants (target=112) to compare a strategy of intensive blood pressure (BP) treatment (target <120/80 mm Hg) guided by remote telemetric home BP monitoring, versus standard primary care, in adult…
- Trial name
- PROHIBIT-ICH (NCT03863665)
- Testing
- A&D BP Digital Blood Pressure Monitor (UA-767PBT-Ci) CE Declaration UA-767PBT-Ci
- Where
- 16 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- University College, London
Cutaneous T Cell Lymphoma, Mycosis Fungoides/Sezary Syndrome
A Trial Assessing the Effect of Pembrolizumab Combined with Radiotherapy in Patients with Relapsed, Refractory, Specified Stages of Cutaneous T-cell Lymphoma (CTCL) Mycosis Fungoides (MF)/Sezary Syndrome (SS)
Trial Subjects (patients), will receive single infusions of pembrolizumab every 3 weeks until disease progression or unacceptable toxicity develops. They will receive radiotherapy at week 12.
- Trial name
- PORT (NCT03385226)
- Testing
- Pembrolizumab, Radiotherapy
- Where
- 11 sites in United Kingdom
- Volunteers
- 46 people
- Sponsor
- University College, London
Diffuse Large B Cell Lymphoma
RadiothErapy priMIng for CAR-T
The REMIT trial will investigate radiotherapy as a preferred bridging method prior to Tisagenlecleucel infusion in patients with relapsed or refractory Diffuse Large B Cell Lymphoma
- Trial name
- REMIT (NCT04726787)
- Testing
- Bridging Radiotherapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Pregnancy Related
Legacies and Futures: Measuring Roles of Resilience and Vulnerability in Pregnancy and Birth Outcomes
Pregnancy care typically assumes patients are heterosexual married women whose gender matches their assigned sex (i.e., cisgender), stigmatizing patients and creating limitations, blocking affirming care.
- Trial name
- NCT05365828
- Where
- 14 sites in United Kingdom
- Volunteers
- 945 people, healthy volunteers welcome
- Sponsor
- University College, London
Hepatocellular Carcinoma
Perioperative Pembrolizumab and Lenvatinib in Resectable Hepatocellular Carcinoma (HCC)
This is a multicentre randomised 3-arm phase II clinical trial in patients with resectable Hepatocellular Carcinoma (HCC). Sixty patients will be randomized 1:1:1 to 6 weeks of pre-operative therapy with: pembrolizumab…
- Trial name
- PRIMER-1 (NCT05185739)
- Testing
- Pembrolizumab, Lenvatinib, Pembrolizumab and Lenvatinib
- Where
- 11 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Neoplasm Metastasis, Pain
Virtual Reality for Advanced Cancer Pain
Background Pain is commonly experienced by people who are living with advanced (incurable) cancer. There is evidence to suggest virtual reality could help to relieve this pain: however, this evidence is poor quality with the…
- Conditions
- Neoplasm Metastasis, Pain, Palliative Care
- Trial name
- VRcan (NCT06534580)
- Testing
- Virtual Reality
- Where
- 4 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Loneliness
INcreasing Adolescent Social and Community SupporT - Pilot
Background: Social prescribing is a mechanism of connecting patients with non-medical forms of support within the community and has been shown to improve loneliness. Yet uptake from young people has been lower than for adults.
- Trial name
- INACT (NCT06656663)
- Testing
- Social Prescribing, Signposting
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- University College, London
Epilepsy, Non-Epileptic Seizure
Volatile Non-Invasive Biomarkers of Epileptic Seizures
Breath and sweat samples will be collected from people who have been admitted to hospital after a potential seizure and analysed by the team.
- Trial name
- VIBES (NCT05725174)
- Testing
- Sample Collection
- Where
- 2 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- University College London Hospitals