Clinical trials: open to volunteers, sponsored by University Health Network, Toronto
Gynecologic Cancer
Study Looking at Biomarkers in Ovarian Cancer
This is a sample study that will collect biological samples (blood, tumor tissue, ascites, and/or other fluids) from gynecological cancer patients for biomarker research.
- Trial name
- NCT03419689
- Testing
- Tumour tissue collection, Blood sample collection, Ascites Collection
- Where
- 7 sites in Canada
- Volunteers
- 510 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Improving Quality of Life for Patients With Breast Cancer Invading the Chest Wall: A Prospective Registry For Patients Undergoing Full Thickness Chest Wall Resection
Although chest wall recurrence of breast cancer is uncommon, it represents a difficult clinical scenario. The role of full thickness chest wall resection (FTCWR) for breast cancer recurrence in the chest wall is controversial and…
- Trial name
- NCT03265379
- Testing
- FACT-B and Brief Pain Inventory
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- University Health Network, Toronto
Cancer, Malignancies Multiple
CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)
This study will collect data on Canadian cancer patients that have uncommon/rare changes in their tumours, such as alterations/rearrangements in the genetic material inside cells - known as deoxyribonucleic acid, or DNA, which…
- Conditions
- Cancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-Related
- Trial name
- CARMA-BROS (NCT04151342)
- Testing
- Cancer treatment with tyrosine kinase inhibitors (TKIs) or other molecularly targeted therapeutic agents., Patient-reported outcomes (PROs)
- Where
- 27 sites in Canada
- Volunteers
- 5,500 people
- Sponsor
- University Health Network, Toronto
Hepatocellular Carcinoma, Recurrent Cancer
Cabozantinib to Treat Recurrent Liver Cancer Post Transplant
This is a phase 2 study that will assess the investigational drug, cabozantinib, in patients with liver cancer (specifically hepatocellular carcinoma) and who had received a liver transplant as a part of curative care, but the…
- Conditions
- Hepatocellular Carcinoma, Recurrent Cancer, Liver Transplant
- Trial name
- NCT04204850
- Testing
- Cabozantinib
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
Patients with multiple myeloma experience a wide range of physical and psychological symptoms from the time of their diagnosis. Meanwhile, patients with aggressive lymphomas undergo unpredictable illness courses, resulting in…
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Multiple Myeloma Stage III, Multiple Myeloma Progression
- Trial name
- EPC-MM+L (NCT06485076)
- Testing
- Early Palliative Care
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Sarcoma, Soft-tissue, Sarcoma
BOLD-100 Plus Doxorubicin in Advanced Soft Tissue Sarcomas
A Phase 1b, non-randomized, single-institution trial designed to assess the safety, tolerability and the highest dose with acceptable toxicity (RP2D) of BOLD-100 in combination with doxorubicin in patients diagnosed with advanced…
- Conditions
- Sarcoma, Soft-tissue, Sarcoma, Sarcoma,Soft Tissue, Sarcomas
- Trial name
- NCT07027423
- Testing
- BOLD-100, Doxorubicin 75 mg/m^2
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Bone Sarcoma, Soft Tissue Sarcoma
In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma
Sarcoma which has spread to the lungs is most often treated with surgery. Even with surgery, most patients will not be cured and will die from their disease, probably because of small cancer cells that are present in the lungs at…
- Conditions
- Bone Sarcoma, Soft Tissue Sarcoma, Pulmonary Metastases
- Trial name
- NCT02811523
- Testing
- Doxorubicin
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Heart Failure, Cardiotoxicity
The HIMALAYAS Trial and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Study: A Multicentre Randomized Controlled Trial
Pediatric, adolescent and young adult cancer survivors (PAYA-CS) are at higher risk of cardiovascular (CV) morbidity and mortality.
- Conditions
- Heart Failure, Cardiotoxicity, Cancer
- Trial name
- HIMALAYAS (NCT05023785)
- Testing
- Cardio-oncology Rehabilitation (CORE)
- Where
- Canada
- Volunteers
- 336 people
- Sponsor
- University Health Network, Toronto
Dementia, Alzheimer Disease
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease…
- Conditions
- Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- CRND TorCA (NCT06529744)
- Where
- 4 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Audit of Medical Waste Disposal
Toronto Western Hospital (TWH) Waste Audit
The goal of this observational study is to learn about the amount and types of anesthesia wastes generated for each surgical case at the Toronto Western Hospital (TWH).
- Trial name
- NCT06680284
- Testing
- Staff Education Program
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Hepatitis B Virus (HBV), Lung Transplant Recipient
Combined Light, ExVivo, and Antivirals for Recipients of Lungs From HBV Donors
The aim of the study is to show that transplantation of lungs from Hepatitis B-infected donors is safe when using EVLP with UV light inactivation plus antivirals
- Trial name
- CLEAR-HBV (NCT07189377)
- Testing
- Entecavir, HBIG, EVLP UV Light Treatment
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Astrocytic Tumor, Oligodendroglial Tumor
Study of How Safe and Effective Tarlatamab is in Brain Cancers
This is a phase 2 study to assess how useful study drug tarlatamab is for the treatment of patients with recurrent/refractory oligodendroglioma or astrocytoma with a mutation in the IDH gene.
- Trial name
- NCT06776250
- Testing
- Tarlatamab
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
SLE - Systemic Lupus Erythematosus
OMERACT SLE Delphi
SLE is a chronic multi-systemic autoimmune disease with clinical manifestations characterized by recurrent flares in disease activity and damage in several organs.
- Trial name
- NCT07136090
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cervical Cancer
FIGO 2018 Stage IB2 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery
This study will include patients with invasive cervical cancer that wish to keep their fertility as much as possible in the future after treatment.
- Trial name
- NCT04016389
- Testing
- Cisplatin, Carboplatin, Paclitaxel
- Where
- 4 sites in United States, Canada
- Volunteers
- 31 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
Evaluating the Effectiveness of the Nurse Ned Clinic
The purpose of this non-randomized control trial is to evaluate the effectiveness of a virtual nurse-led survivorship clinic for prostate cancer (PCa) survivors.
- Trial name
- NurseNed (NCT05033301)
- Testing
- Nurse Ned Clinic
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University Health Network, Toronto
Metastatic Prostate Cancer
TOward a comPrehensive Supportive Care Intervention for Older Men With Metastatic Prostate Cancer
TOPCOP3 is a pilot factorial RCT of geriatric assessment and management, remote symptom monitoring, both interventions or neither, accompanied by an embedded process evaluation.
- Trial name
- TOPCOP3 (NCT05582772)
- Testing
- GA+M Intervention, RSM intervention, GA+RSM intervention
- Where
- 3 sites in Canada
- Volunteers
- 168 people
- Sponsor
- University Health Network, Toronto
Lung Transplant; Complications, Ventilator-Induced Lung Injury
Inspiratory Work of Breathing Before and After Extubation
Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator).
- Conditions
- Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
- Trial name
- INTEGRATION (NCT07017608)
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- University Health Network, Toronto
Stroke, Fatigue
Modafinil and Exercise for Post Stroke Fatigue
A stroke happens when blood flow to the brain is stopped and the brain gets damaged. At least half of people with a stroke have fatigue months and even years later.
- Conditions
- Stroke, Fatigue, Modafinil, Exercise
- Trial name
- MODEX (NCT06354985)
- Testing
- Modafinil 200mg, Exercise
- Volunteers
- 212 people
- Sponsor
- University Health Network, Toronto
Hepatitis B, Chronic
Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection [VISION]
This is a Phase II Investigator-Initiated Study to understand the vaccinal effect of HBsAg monoclonal Ab VIR-3434 in chronic hepatitis B infection.
- Trial name
- NCT06216470
- Testing
- VIR-3434
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Hemianopia, Brain Injuries
Biofeedback Training for Hemianopia
This is a prospective study that compares biofeedback training on the microperimetry (BT) to a control group in patient s with hemianopia.
- Trial name
- NCT06995313
- Testing
- Biofeedback training
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto