Clinical trials: open to volunteers, sponsored by University Health Network, Toronto
Tonsil Neoplasm, Oropharynx Neoplasm
Buccal Fat for Transoral Robotic Lateral Oropharyngectomy Defects to and Postoperative Pain
The goal of this randomized clinical trial is to determine the pain intensity during rest and swallowing in patients undergoing transoral robotic surgery for tonsil lesions with and without buccal fat reconstruction.
- Conditions
- Tonsil Neoplasm, Oropharynx Neoplasm, Transoral Robotic Surgery
- Trial name
- BOLT (NCT06965738)
- Testing
- Buccal fat reconstruction, No buccal fat reconstruction
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Esophageal Cancer, Gastric Cancer
Chemoimmunotherapy Followed by Surgery for Oligometastatic Esophagogastric Cancer: (TORO Protocol)
Esophageal cancer and cancers of the gastroesophageal junction (GEJ) are among the most common malignancies worldwide. The outcome for these patients remains very poor.
- Conditions
- Esophageal Cancer, Gastric Cancer, Oligometastatic Disease
- Trial name
- TORO (NCT06668454)
- Testing
- Surgical resection followed by preoperative chemoimmunotherapy for oligometastatic esophagogastric cancer
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University Health Network, Toronto
Esophageal Cancer
Tissue Collection Protocol for Gastroesophageal Cancers
This proposed collection of primary tumor cells lines will benefit esophageal cancer research within the University Health Network.
- Trial name
- NCT02495337
- Testing
- Tissue Collection
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Esophagogastric Adenocarcinoma
Molecular Characteristics of Gastroesophageal Adenocarcinoma (MOCHA): A Prospective Feasibility Study
Researchers are looking to further our knowledge on disease biology and treatment selection for gastroesophageal adenocarcinoma.
- Trial name
- MOCHA (NCT04219137)
- Testing
- Molecular Profiling
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Hemianopsia, Homonymous, Brain Injury
Biofeedback for Hemianopia Vision Rehabilitation
Patients with brain injury secondary to stroke, surgery, or trauma frequently suffer from homonymous hemianopia, defined as vision loss in one hemifield secondary to retro- chiasmal lesion.
- Conditions
- Hemianopsia, Homonymous, Brain Injury, Stroke, Brain Tumor
- Trial name
- NCT05397873
- Testing
- Biofeedback training
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Alzheimer Disease
Deep Brain Stimulation of the Pedunculopontine Nucleus for Alzheimer's Disease
Alzheimer's disease (AD) is a brain disorder that gradually impacts cognitive functions such as memory, thinking, and daily functioning.
- Trial name
- DBS-PPN-AD (NCT06936124)
- Testing
- Deep Brain Stimulation of the Pedunculopontine Nucleus
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Patient Engagement, Patient Activation
At-home Breast Oncology Care Delivered With E-health Solutions
The COVID-19 pandemic has significantly impacted healthcare service delivery, highlighting the need for high quality virtual patient care.
- Conditions
- Patient Engagement, Patient Activation, Patient Reported Outcome Measures
- Trial name
- ABODE (NCT05989477)
- Testing
- At-home Breast Oncology care Delivered with E-health solutions - ABODE
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Thyroid Nodule, Thyroid Cancer
The Safety and Feasibility of Radiofrequency Ablation to Treat Low-risk Thyroid Cancer
The goal of this clinical trial is to test radiofrequency ablation (RFA) in thyroid cancers ≤2 cm in diameter. The main question it aims to answer is: What is the feasibility of RFA use for low-risk thyroid cancers (≤2 cm)?…
- Trial name
- NCT06929650
- Testing
- Radiofrequency ablation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Diabetes, Diabetic Retinopathy
Project Open - Use of Administrative Health Data to Increase Diabetic Retinopathy Screening
Early detection through regular diabetic retinopathy screening (DRS) is an effective method of preventing vision loss by enabling earlier intervention and timely treatment.
- Trial name
- NCT05074342
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University Health Network, Toronto
Corticobasal Syndrome, Progressive Supranuclear Palsy
Diagnosing Frontotemporal Lobar Degeneration
To establish diagnostic tools to make an accurate clinical and pathological diagnosis of patients with clinical FTLD syndromes
- Conditions
- Corticobasal Syndrome, Progressive Supranuclear Palsy, Behavioral Variant Frontotemporal Dementia, Semantic Dementia
- Trial name
- NCT02964637
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Dementia
VR&R: Providing Caregiver Respite by Managing BPSDs and Improving QoL in People with Dementia Using Immersive VR-Therapy
The goal of this interventional trial is to learn about how immersive Virtual Reality (VR) therapy can be used at home by individuals with dementia, with assistance from their informal (e.g., friend/family) caregivers.
- Trial name
- VR&R (NCT05867641)
- Testing
- Immersive VR Therapy in Head-Mounted Display (HMD) (Solo), Immersive VR Therapy in a Head-Mounted Display (HMD) (Social)
- Where
- 7 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Surgery
Improving Patient Sleep Prior to Elective Surgery
The goal of this clinical trial is to learn if changing sleep behaviour can improve sleep health in patients undergoing prehabilitation before elective surgery.
- Trial name
- NCT06762639
- Testing
- Personalized Sleep Prehabilitation (PSP), Standard of Care Prehabilitation
- Where
- Canada
- Volunteers
- 154 people
- Sponsor
- University Health Network, Toronto
Anticoagulant-induced Bleeding, Direct Oral Anticoagulant
Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation Pilot Study
The peri-procedural management of direct oral anticoagulants (DOACs) in persons with cancer (PWC) undergoing tunneled or port central venous catheter (CVC) insertion is a common but understudied clinical problem, with conflicting…
- Conditions
- Anticoagulant-induced Bleeding, Direct Oral Anticoagulant, Cancer, Central Venous Catheter
- Trial name
- VENO CAT (NCT06887270)
- Testing
- Continued DOAC, Interrupted DOAC
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Cardiac Surgery Requiring Cardiopulmonary Bypass
Relationship of Point-of-care Coagulation Assays with Clinical Outcomes in Cardiac Surgery: a Retrospective Cohort Study
The goal of this observational study is to determine the relationship of ROTEM point-of-care coagulation assay parameters with excessive bleeding and clinical outcomes in patients undergoing cardiac surgery at Toronto General…
- Trial name
- NCT06882759
- Testing
- No intervention (observational study)
- Volunteers
- 15,000 people
- Sponsor
- University Health Network, Toronto
Endometrial Cancer, Atypical Hyperplasia
Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium
A growing population of young women with obesity are developing atypical hyperplasia (pre-cancer) and endometrial cancer. Progestin is the standard treatment for women who wish to preserve fertility, but this approach does not…
- Conditions
- Endometrial Cancer, Atypical Hyperplasia, Bariatric Surgery Candidate
- Trial name
- B-FiERCE (NCT04008563)
- Testing
- Bariatric Surgery
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University Health Network, Toronto
Ventilation Therapy; Complications
Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to…
- Trial name
- BATMAN (NCT06142773)
- Testing
- Tidal Volume set on ventilator
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Asthma
Effects of Compression Stockings in Asthma Symptoms at Night
Nocturnal worsening of asthma is common. It is characterized by overnight exacerbation of asthma symptoms such as shortness of breath, chest tightness, coughing, and wheezing, increased need of asthma medications and airway…
- Trial name
- NCT03303586
- Testing
- Compression Stockings, Control
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Adhesive Capsulitis of the Shoulder
Dose Efficacy in Adhesive Capsulitis
The purpose of this study is to find out if the treatment of adhesive capsulitis with 40 mg of methylprednisolone in combination with a hydrodilatation is comparable to 80 mg of methylprednisolone for pain reduction, improving…
- Trial name
- NCT06848374
- Testing
- 40 mg Methylprednisolone, 80 mg Methylprednisolone
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cancer, Breast Cancer
Genomic Investigation of Unusual Responders
Studies have shown that tumors from the same patient may respond very differently to the same therapeutic agents. This study aims to investigate the genetic basis of tumors that respond abnormally well or poorly to therapeutic…
- Conditions
- Cancer, Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer
- Trial name
- GENIUS (NCT03740503)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Anesthesia, Brain Cancer
Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study
Cancer is a leading cause of death worldwide. It is estimated that approximately 55,000 Canadians are surviving with brain tumors.
- Conditions
- Anesthesia, Brain Cancer, Survival
- Trial name
- NCT04962672
- Testing
- Propofol group, Sevoflurane group
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto