Clinical trials: open to volunteers, sponsored by University Health Network, Toronto
Head and Neck Cancer
SALI-10 Probiotic to Reduce Osteoradionecrosis and Dental Toxicity Following Radiation Therapy for Head and Neck Cancer
This Phase III randomized controlled trial will evaluate whether long-term use of the oral probiotic Streptococcus salivarius strain SALI-10 (SALI-10) can reduce the risk of radiation-related major adverse dental events (MADE) in…
- Trial name
- DIAMOND (NCT07883005)
- Testing
- Standard of Care (SOC), Experimental drug
- Where
- Canada
- Volunteers
- 288 people
- Sponsor
- University Health Network, Toronto
Prostate Adenocarcinoma, Iliac Nodal Disease
Elective Adaptive Radiation With SBRT for Improved DurabilitY of Response
This prospective, single-arm feasibility study will include patients with prostate cancer that have controlled local disease diagnosed with oligorecurrent para-aortic nodal disease and/or common iliac nodal disease detected by…
- Conditions
- Prostate Adenocarcinoma, Iliac Nodal Disease, Para-aortic Lymph Node Metastasis, Para-aortic Nodal Disease
- Trial name
- EASY (NCT06831032)
- Testing
- Adaptive radiotherapy using SBRT
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
Advanced Cancer, Stage IV Solid Tumor Cancer
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial
Phase II randomized controlled trial, followed by an open-label extension phase. In the main study, participants will receive either a single high or low dose of psilocybin in the context of Psilocybin-assisted Existential…
- Conditions
- Advanced Cancer, Stage IV Solid Tumor Cancer, Stage IV Sarcoma of Bone, Stage IV Lymphoma
- Trial name
- PEARL RCT (NCT07820033)
- Testing
- Psilocybin (high dose), Psilocybin (low dose), PEARL Therapy
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University Health Network, Toronto
Hypertrophic Cardiomyopathy
Echocardiographic Perspectives on Transient Mitral Regurgitation After Septal Myectomy
Mitral regurgitation (MR) following septal myectomy for hypertrophic obstructive cardiomyopathy may persist despite relief of systolic anterior motion and left ventricular outflow tract obstruction.
- Trial name
- TMRSM_R (NCT07831811)
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Breast Cancer, HER2-positive Breast Cancer
Kadcyla And Neratinib for Interception of HER2+ Breast Cancer With Molecular Residual Disease
This is a Phase 2 study for patients with resected Stage I-III HER2+ breast cancer with detected molecular residual disease (MRD+) following standard neoadjuvant and locoregional therapy delivered with curative intent.
- Trial name
- NCT05388149
- Testing
- Neratinib
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Cutaneous Melanoma, Melanoma Stage IV
Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma
Clear-Me is a biomarker-driven phase II study that tests whether the combination anti- lymphocyte-activation gene-3 (LAG3)/anti-programmed cell death protein 1(PD-1) inhibition Bristol-Myers Squibb (BMS986213) is superior to…
- Conditions
- Cutaneous Melanoma, Melanoma Stage IV, Mucosal Melanoma
- Trial name
- ClearMe (NCT06319196)
- Testing
- Opdualag, Nivolumab
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University Health Network, Toronto
Autonomic Dysfunction
Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition
Post-COVID Condition (PCC) affects roughly 2.1 million Canadians, carrying an annual economic burden of CAD $7.8-50.6 billion. It presents across multiple organ systems with symptoms including fatigue, brain fog, palpitations…
- Trial name
- CeASE (NCT07468604)
- Testing
- 5 mL of 0.25% bupivacaine with epinephrine (1:200,000)
- Where
- 2 sites in Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
Post-Operative Prostate Cancer
Comparing Moderately and Ultra Hypofractionated Radiation Treatments for Post-operative Prostate Cancer
This is a multi-institution, randomized, non-inferiority Phase II trial comparing external beam radiotherapy delivered as 54 Gy in 20 fractions to prostate bed +/- 44 Gy in 20 fractions to pelvic lymph nodes delivered daily with…
- Trial name
- AMPORA (NCT06409910)
- Testing
- Radiotherapy
- Where
- 3 sites in Canada
- Volunteers
- 204 people
- Sponsor
- University Health Network, Toronto
Hereditary Cancer Syndrome
CfDNA in Hereditary And High-risk Malignancies 2
The goal of this study is to understand the performance of an experimental blood test that aims to detect early tumors in patients with hereditary cancer syndromes.
- Trial name
- CHARM2 (NCT06726642)
- Testing
- Cell-free DNA analysis
- Where
- 8 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
Bladder Cancer, Bladder Urothelial Carcinoma
Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
Upper tract urothelial cancer (UTUC) is cancer in the lining of the kidney or ureter (the tube that drains the kidney). This type of cancer is rare and as a result, there are only a few studies that have looked at it.
- Trial name
- NAUTICAL (NCT04574960)
- Testing
- Gemcitabine, Cisplatin, Carboplatin
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- University Health Network, Toronto
Chronic Low Back Pain (CLBP), Nociplastic Pain
PRT for Chronic Low Back Pain
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) is a feasible and acceptable treatment to complete for working-age adults (ages 18-65) with chronic low back pain.
- Trial name
- NCT07696741
- Testing
- Pain Reprocessing Therapy, Monitoring and Education
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Bleeding, Platelets
Autologous Cold-stored Apheresis Platelets
The Auto-PLTS Study is a single-centre trial performed at Toronto General Hospital (TGH) that uses a randomized, patient preference design.
- Conditions
- Bleeding, Platelets, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- Auto-PLTS (NCT07064954)
- Testing
- Autologous Cold-Stored Platelets, Allogeneic Room Temperature-Stored Platelets (Standard of Care)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)
Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC
This is a phase II, open-label study to assess the efficacy of AZD2936 in terms of molecular residual disease (MRD) clearance and treatment outcome in patients with MRD after definitive treatment for high risk locoregionally…
- Trial name
- MERIDIAN (NCT05414032)
- Testing
- AZD2936
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- University Health Network, Toronto
Pulmonary Hypertension
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation
Radiotherapy (RT) is a well-known and established therapy or adjuvant therapy for the treatment of thoracic cancer It uses a high energy radiation from x-rays, gamma rays and other charged particles that assist in damaging the…
- Trial name
- NCT04901884
- Testing
- PET/MR with 18F-FDG
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cholangiocarcinoma, Intrahepatic
Liver Transplant for Stable, Advanced Intrahepatic Cholangiocarcinoma
Diagnosis of intrahepatic cholangiocarcinoma (iCCA) is an increasingly common form of primary liver cancer, but patients with this diagnosis are not currently eligible for LT.
- Trial name
- NCT04195503
- Testing
- Liver Transplantation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)
The BeeHive study is an investigator-initiated, single center, open-label phase II clinical trial that is designed to conduct a comprehensive multiomic biomarker evaluation across two single-arm cohorts to elucidate mechanisms of…
- Trial name
- BeeHive (NCT07408063)
- Testing
- GSK5764227, Dostarlimab
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Testis Cancer
miRNA to Guide Appropriate Intervention of Small Testis Masses
This study aims to determine, for the first time, if miRNA-371a-3p can be used as an accurate biomarker to identify which small (≤ 2cm) testicular masses are malignant and aid in clinical decision-making to offer surgery or…
- Trial name
- miRSTM (NCT07852871)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Multiple Myeloma
PET/MR Scan With [68Ga]Ga-PentixaFor (CXCR4) vs Standard of Care (SOC) for Initial Staging and Follow up in Multiple Myeloma (MM)
Multiple myeloma is a disease mainly located in participants bones. Usually a participants physician arrives at this diagnosis by doing blood tests and ordering standard of care imaging tests (18F-FDG PET/CT and maybe additional…
- Trial name
- NCT06871176
- Testing
- [68Ga]Ga-PentixaFor
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Lung Metastases, Colorectal Cancer Metastatic
In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung
This study is investigating a new technique for delivering chemotherapy directly into the lungs at the time of surgery. Delivering chemotherapy directly to the lungs could potentially kill any microscopic cancer cells that are…
- Conditions
- Lung Metastases, Colorectal Cancer Metastatic, Colorectal Cancer
- Trial name
- NCT05611034
- Testing
- Oxaliplatin
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Parkinson Disease (PD)
Effects of Excitatory and Inhibitory LIFUS of GPi in Parkinsonian Patients Without DBS
Low intensity focused ultrasound (LIFUS) is a novel non-invasive brain stimulation (NIBS) technique that permits stimulation with high spatial focality and can reach greater depth compared other methods.
- Trial name
- PD GPi-TUS (NCT07846007)
- Testing
- LIFUS: Active 5 Hz Theta Burst, LIFUS: Active 10 Hz
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto