Clinical trials: completed, sponsored by University Health Network, Toronto
Spinal Deformity
Prehab for Adult Spinal Deformity Surgery
Prehabilitation is defined as the process of enhancing patients' functional capacity and overall fitness to enable them to withstand a forthcoming stressor (e.g. surgery).
- Trial name
- NCT05452057
- Testing
- Prehabilitation
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Living Donor Liver Transplantation
PRehab tO PreparE Living Liver Donors for Enhanced Recovery
1. to determine if a Phase III RCT of prehab vs usual care for LLDs is feasible (including rates of recruitment, adherence, adverse events, and attrition); 2.
- Trial name
- PROPELLER (NCT05431361)
- Testing
- Prehabilitation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Automated Breast Radiation Therapy Using an MR-Guided Process
In the proposed research study, we are investigating the feasibility of integrating automated planning tools to MR images acquired using a novel MR-guided linac, for on-line adaptive radiation treatment.
- Trial name
- Auto Breast RT (NCT01999062)
- Testing
- IMRT + CT + MR scan
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
Prostate Hypoxia FAZA
The purpose of this study is to look for low levels of oxygen (hypoxia) in prostate cancer using a special x-ray test called a positron emission tomography (PET)scan.
- Trial name
- NCT01567800
- Testing
- 18F-Fluoroazomycin Arabinoside (18F-FAZA)
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University Health Network, Toronto
Prostatic Neoplasms
Transrectal Tumour Oxygen - US Army
Prostate cancer is now the most commonly diagnosed tumor among men in the United States. Most patients have tumors that are confined to the prostate gland at diagnosis and are suitable for treatment with surgery or radiotherapy…
- Trial name
- NCT00160979
- Testing
- Pre-treatment tumour oxygen measurements
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University Health Network, Toronto
Solid Tumors With Oligometastatic Spread
5 Fraction Stereotactic Body Radiation Therapy for Oligometastases Regimen, for Extra-Cranial Oligometastases
This is a prospective Phase II study.The purpose of this study is to monitor the side effects and treatment outcomes of delivering higher doses of radiation therapy to the tumour, while limiting the dose of radiation to the…
- Trial name
- 5fr SBRT (NCT01761929)
- Testing
- Radiation: 50Gy in 5 fr (max) to 25 Gy in 5 fr (min). Dose adapted to deliver the highest dose level while respecting normal tissue tolerance
- Where
- Canada
- Volunteers
- 138 people
- Sponsor
- University Health Network, Toronto
Malignant Pleural Mesothelioma
Short Neoadjuvant Hemithoracic IMRT for MPM
Malignant pleural mesotheliomas (MPMs) are tumours associated with asbestos exposure involving the tissue lining surrounding the lung.
- Trial name
- NCT00797719
- Testing
- Pre-op RT +/- chemotherapy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer, Prostatectomy
Timing of Post-prostatectomy PSMA Imaging
The investigators will randomize patients presenting with early BCR with a negative baseline PSMA PET/CT, to upfront SRT or surveillance. Early BCR is defined as a PSA relapse of >0.1 to <0.3 ng/mL.
- Trial name
- TOPP (NCT05008900)
- Testing
- Salvage radiotherapy
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Brain Metastases
A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases
This study will be a non-randomized phase II trial for patients with one to six brain metastases, at least one of which is appropriate for surgical resection.
- Trial name
- NASRS (NCT03368625)
- Testing
- Stereotactic Radiosurgery
- Where
- 2 sites in Canada, Germany
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Palliative, Advanced Cancer
Immunotherapy And Palliative Radiotherapy Combined In Patients With Advanced Malignancy
Immunotherapy includes a class of medication called checkpoint inhibitors, which are a relatively new medication therapy for many types of cancer which are metastatic, meaning it has spread to other parts of the body.Immune…
- Conditions
- Palliative, Advanced Cancer, Immunotherapy, Radiation Therapy
- Trial name
- NCT03042156
- Testing
- Palliative Radiation Therapy
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University Health Network, Toronto
Non-small Cell Lung Carcinoma
Observing Patients With Palliative Asymptomatic Centrally Located Advanced Non-small Cell Lung Carcinoma (NSCLC)
The aim of the study is to assess current practice within PROP \& lung teams, for treating asymptomatic patients with centrally located non-small cell lung cancer (NSCLC), and to observe outcomes for those patients receiving…
- Trial name
- NCT01279408
- Testing
- None: Questionnaire Study
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University Health Network, Toronto
Advanced Breast Cancer, Advanced Colorectal Cancer
Rehabilitation for People With Advanced Cancer
The proposed study is a Phase II, feasibility, randomized controlled preference based study. This will be conducted in Vancouver and Toronto and includes breast and colorectal cancers.
- Conditions
- Advanced Breast Cancer, Advanced Colorectal Cancer, Cancer Rehabilitation
- Trial name
- NCT05424068
- Testing
- In-person rehabilitaiton group, Virtual rehabilitation group
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- University Health Network, Toronto
Long COVID, Post COVID Condition
RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine
The researchers propose to develop a Canada-wide, adaptive randomized clinical platform trial to assess the effectiveness of various interventions in patients with lingering symptoms of COVID-19 ("Long COVID").
- Conditions
- Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19
- Trial name
- RECLAIM (NCT05513560)
- Testing
- Ibudilast, Pentoxifylline
- Where
- 3 sites in Canada
- Volunteers
- 460 people
- Sponsor
- University Health Network, Toronto
Pancreatic Cancer Metastatic, Pancreatic Ductal Adenocarcinoma
Pancreatic Adenocarcinoma Signature Stratification for Treatment
This is a randomized multicentre phase II trial with a large translational component. The trial will evaluate the two standard chemotherapy regimens: modified folfirinox (mFFX) and gemcitabine/nab-paclitaxel (GA), in patients…
- Conditions
- Pancreatic Cancer Metastatic, Pancreatic Ductal Adenocarcinoma, Advanced Pancreatic Cancer
- Trial name
- PASS-01 (NCT04469556)
- Testing
- Folfirinox, Gemcitabine/nab-paclitaxel
- Where
- 6 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Carcinoma of Prostate
PSMA PET Registry (18F-DCFPyL)
The purpose of the Princess Margaret Cancer Centre PSMA registry is to assess the contribution of 18F-DCFPyL (PSMA) PET imaging (PET/MR or PET/CT) to the management of patients with prostate cancer (PCa).
- Trial name
- PM-PPR (NCT03535831)
- Testing
- 18F-DCFPyL
- Where
- Canada
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Oncology
Pilot Trial of Virtual and In-person STEP2
The goal of this clinical trial is to assess the feasibility of offering oncology patients a referral to the outpatient palliative care clinic based on virtual symptom screening before oncology clinic appointments, and to…
- Trial name
- STEP2 (NCT06326554)
- Testing
- Virtual and in-person Symptom screening with Targeted Early Palliative care (STEP2)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
A Web-based Peer Navigation Program for Men With Prostate Cancer
One in nine Canadian men will be diagnosed with prostate cancer (PC) in their lifetime. Although all treatment options can be effective in controlling the disease, treatment side effects such as problems with erections and…
- Trial name
- NCT05041504
- Testing
- Peer navigation, Active wait list control
- Where
- 3 sites in Canada
- Volunteers
- 184 people
- Sponsor
- University Health Network, Toronto
Salivary Gland Cancer, Metastatic
A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes
This is a study of select drug therapies in patients with salivary gland cancer. The study has two phases: a molecular profiling phase (phase 1) and a treatment phase (phase 2).
- Conditions
- Salivary Gland Cancer, Metastatic, Advanced, Recurrent
- Trial name
- NCT02069730
- Testing
- Selinexor, EGFR or HER2 Inhibitor, FGFR Inhibitor
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- University Health Network, Toronto
Cancer, Leukemia
Peer Support Group for Adolescent and Young Adult (AYA) Allogeneic Stem Cell Transplant Recipients
Allogeneic Haemopoietic Stem Cell Transplant (Allo-HSCT) is a potentially curative option for patients with both malignant and non-malignant hematological disorders.
- Conditions
- Cancer, Leukemia, Stem Cell Transplant
- Trial name
- NCT06704243
- Testing
- Peer Support
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
Mesothelioma, Malignant
......SMARTEST Trial......
The SMARTEST trial is a phase II non-blinded randomized trial designed to evaluate the benefit of low dose cyclophosphamide in sequential combination with sub-ablative radiation (Arm A) versus sub-ablative radiation alone (Arm B)…
- Trial name
- NCT05380713
- Testing
- Cyclophosphamide, Tremelimumab, Durvalumab
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto