Clinical trials: open to volunteers, sponsored by University Health Network, Toronto
Metastatic Prostate Cancer
Duration of Androgen Receptor Pathway Inhibitor and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)
This is a multi-centre, investigator-initiated, three-arm, randomized trial to investigate the addition on androgen receptor pathway inhibitor and atorvastatin to standard of care radiation and hormone therapy improve quality of…
- Trial name
- DIRECT (NCT05404139)
- Testing
- Abiraterone, Standard of Care SBRT and ADT, Atorvastatin
- Where
- 2 sites in Canada
- Volunteers
- 352 people
- Sponsor
- University Health Network, Toronto
Hip-fracture, Surgery
Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients
The INTACT-HIP trial study will evaluate feasibility of conducting a randomized, double-blinded controlled trial comparing postoperative treatment with intravenous (IV) acetaminophen versus oral acetaminophen, in older adults…
- Trial name
- INTACT-HIP (NCT05425355)
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University Health Network, Toronto
Pain, Sleep
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
This prospective observational study aims to describe the effectiveness of MC on pain, epilepsy, sleep and /or anxiety/depression in a cohorts of patients authorized to use MC, using pre-defined, validated self assessment scales.
- Conditions
- Pain, Sleep, Anxiety, Depression
- Trial name
- MC-RWE (NCT04526093)
- Testing
- Medical Cannabis
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
Breast Cancer, Breast Cancer Recurrent
Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)
Breast-conserving surgery followed by re-irradiation with partial breast irradiation (rPBI) has recently been found to be a safe alternative to mastectomy for women who have undergone prior whole breast radiation.
- Trial name
- PRESERVE (NCT05592938)
- Testing
- rPBI
- Where
- 19 sites in United States, Australia and 8 more
- Volunteers
- 171 people
- Sponsor
- University Health Network, Toronto
Osteoarthritis of Knee, Osteoarthritis Hip
Cannabinoids for Osteoarthritis Pain Effectiveness Trial
This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians.
- Trial name
- COPE (NCT06878417)
- Testing
- CBD, THC
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Primary Graft Dysfunction
Prospective Reduction Of Transplant Complications Through Enhanced Preservation Therapy to Prevent Primary Graft Dysfunction
The goal of this clinical trial is to test the feasibility of the study protocol comparing a novel temperature control system - Xo Port Organ Preservation System - to static ice for heat preservation for Heart Transplant.
- Trial name
- PROTECT-PGD (NCT07230886)
- Testing
- Xo Port Organ Preservation System, Standard of Care - Ice packs
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Caregiver, Cardiac Disease
Well-being Program for Caregivers of Patients With Advanced Cardiac and Pulmonary Disease
Caregivers provide essential support for people living with advanced heart or lung disease, including daily tasks, emotional support, and help with medical care.
- Conditions
- Caregiver, Cardiac Disease, Pulmonary Diseases
- Trial name
- NCT07685912
- Testing
- Multimodal Well-being Program
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Lymphoma Receiving CAR-T Therapy
Fecal Microbiota Transplantation in Patients Undergoing Chimeric Antigen Receptor T-cell Therapy and Allogeneic Stem Cell Transplant: A Pilot Study
This is a single site pilot trial will evaluate the feasibility and safety of fecal microbiota transplantation (FMT) in patients with B-cell lymphoma who are undergoing CAR-T or in patients with moderate to high-risk acute…
- Trial name
- FMT (NCT07509450)
- Testing
- Fecal Microbial Transplant Enema
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Castrate Resistance Prostate Cancer, OligoProgressive Metastatic Disease
Stereotactic Body Radiotherapy or Standard of Care for Prostate Oligoprogressive Cancer
This is a single centre, interventional, randomized Phase II, two-arm prospective trial investigating if Stereotactic Body Radiotherapy (SBRT) to all sites of Oligopressive (OP) disease while remaining on current Systemic Therapy…
- Trial name
- SECURE (NCT06927635)
- Testing
- Stereotactic Body Radiation Therapy (SBRT), Systemic therapy
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer, Patient Satisfaction
Digital Education in Colorectal Cancer Patients
The goal of this clinical trial is to evaluate the impact of integrating video- based education in colorectal cancer surgery, with a specific focus on patient's perspective.
- Conditions
- Colorectal Cancer, Patient Satisfaction, Patient Engagement, Patient
- Trial name
- GUIDE (NCT07686133)
- Testing
- Video platform
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Myeloproliferative Neoplasm
Study of Venetoclax and Azacitidine in Advanced BCR-ABL Negative Myeloproliferative Neoplasms
The purpose of this research study is to look at how safe and useful a drug called azacitidine in combination with a drug called venetoclax, is in people with accelerated or blast phase BRC-ABL negative myeloproliferative…
- Trial name
- NCT05074355
- Testing
- Azacitidine, Venetoclax
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Heart Failure, Heart Failure - NYHA II - IV
Ted Rogers Understanding of Exacerbations in Heart Failure 2: Monitor
Heart Failure (HF) is a complex disease associated with the highest burden of cost to the healthcare system. The cardiopulmonary exercise test (CPET) is instrumental in determining the prognosis of patients with HF.
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Patients, Cardiopulmonary Exercise Test
- Trial name
- TRUE-HF 2 (NCT07447908)
- Where
- 3 sites in Canada
- Volunteers
- 360 people
- Sponsor
- University Health Network, Toronto
Advanced Cancer
Contrast-enhanced CBCT With C-arm HyperSight Technology
This is a single-arm prospective, feasibility study evaluating the intravenous contrast-enhanced cone beam computed tomography (IV CBCT) for image guidance during radiotherapy.
- Trial name
- IV-CBCT (NCT07648160)
- Testing
- Intravenous contrast-enhanced cone beam computed tomography
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Delirium - Postoperative, Cardiac Surgery
Cerebral Autoregulation and Delirium Study
Approximately one in four elderly patients develops postoperative delirium (POD) after cardiac surgery. POD is associated with prolonged hospitalization, increased mortality, and higher health care costs.
- Trial name
- AUTO-POD (NCT07671404)
- Testing
- Mespere NeuroOs (Mespere Life Sciences) monitor
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Pancreas Ductal Adenocarcinoma, Pancreas Cancer, Metastatic
Samuraciclib in Combination With Gemcitabine/Nab-Paclitaxel in Patients With Metastatic Basal-Like Pancreatic Cancer
The purpose of this study is to find the highest dose of a drug, samuraciclib, that can be given with standard of care chemotherapy (gemcitabine and nab-paclitaxel) without causing very severe side effects.
- Conditions
- Pancreas Ductal Adenocarcinoma, Pancreas Cancer, Metastatic, Pancreatic Adenocarcinoma Metastatic, Adenosquamous Carcinoma of the Pancreas
- Trial name
- SONIC (NCT07665684)
- Testing
- Samuraciclib + Gemcitabine & Nab-Paclitaxel
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- University Health Network, Toronto
Soft Tissue Sarcoma
Circulating Tumor DNA in Soft Tissue Sarcoma
This research study will collect blood and tumor tissue samples from patients with soft tissue sarcoma to look at circulating tumor deoxyribonucleic acid (DNA).
- Trial name
- NCT03818412
- Testing
- Archival tumor tissue collection and blood draws
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Classical Hodgkin Lymphoma, Relapsed Cancer
Study of Pembrolizumab With Bendamustine in Hodgkin Lymphoma
This is a phase 2 open-label study to test the safety and effectiveness of combining pembrolizumab and bendamustine in patients with relapsed (cancer that has come back or started getting worse) or refractory (cancer that is not…
- Conditions
- Classical Hodgkin Lymphoma, Relapsed Cancer, Refractory Cancer
- Trial name
- NCT04510636
- Testing
- Pembrolizumab, Bendamustine Hydrochloride
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Pancreatic Ductal Adenocarcinoma
Durvalumab and Oleclumab in Resectable PDAC
This is a multi-site Canadian, window of opportunity study to evaluate the immune activity of durvalumab and oleclumab in resectable pancreatic ductal adenocarcinoma (PDAC) when given prior to surgery.
- Trial name
- DORA (NCT06060405)
- Testing
- Durvalumab, Oleclumab
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Chronic Pain, Knee Pain Chronic
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total…
- Conditions
- Chronic Pain, Knee Pain Chronic, Post Operative Pain
- Trial name
- PROVISION (NCT06123715)
- Testing
- Vitamin C
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- University Health Network, Toronto
Pancreatic Ductal Carcinoma, Advanced Cancer
Using Tumor Models to Determine Treatments
The purpose of this study is to see if using Patient Derived Organoids (PDO) to choose a drug for the treatment of pancreatic cancer individually for each patient is useful.
- Conditions
- Pancreatic Ductal Carcinoma, Advanced Cancer, Epithelial Tumor
- Trial name
- NCT06813079
- Testing
- Cobimetinib, Ponatinib, Brigatinib
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto