Clinical trials: sponsored by University Health Network, Toronto
Epilepsy
Efficacy of Modified Ketogenic Diet (Atkins) in Management of Epilepsy
The purpose of this study is to determine whether patients with uncontrolled epilepsy can follow a low carbohydrate diet long-term and if so, how will that diet affect their seizures
- Trial name
- NCT00188500
- Testing
- atkins diet, ability to follow low carbohydrate diet
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Left Ventricular Dysfunction
Insulin Cardioplegia for Poor Left Ventricular Function
The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular…
- Trial name
- NCT00188994
- Testing
- Insulin Cardioplegia
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Hepatitis B
Apoptosis and Hepatitis B: The Role of Apoptosis in Patients Who Are HBeAg Negative
A large number hepatitis B surface antigen positive individuals are HBeAg negative with normal liver tests. Historically, such patients were thought to have suppressed viral replication and were considered to be at low risk for…
- Trial name
- NCT00152880
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Hepatitis C, Hepatitis B
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis
The purpose of this research is to study body materials like blood proteins as well as white blood cell and liver cellular RNA in individuals with liver diseases such as chronic viral hepatitis with or without hepatoma and…
- Conditions
- Hepatitis C, Hepatitis B, Autoimmune Hepatitis, Liver Cirrhosis, Biliary
- Trial name
- NCT00160940
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Glaucoma
The Results of Ahmed Valve Operations
Glaucoma drainage devices are usually placed in the superior quadrants. The superotemporal quadrant is usually the site of choice.
- Trial name
- NCT00193960
- Testing
- 1) Intraocular pressure 2) visual acuity
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Liver Cirrhosis, Biliary, Biliary Cirrhosis, Primary
Identification of the Genetic Variants Responsible for Primary Biliary Cirrhosis (PBC)
Primary biliary cirrhosis (PBC) is a disease of the liver, which predominantly affects women. It causes slowly progressive liver disease, which eventually causes liver failure, requiring a liver transplant.
- Trial name
- NCT00145964
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Hepatitis C, Hepatitis B
Neurocognitive Functioning in Patients With Hepatitis C Pre- and Post-Treatment With Antiviral Medication
The estimated global prevalence of hepatitis C (HCV) infection is approximately 3% (170 million individuals). In Canada there are an estimated 240,000 people infected with HCV.
- Trial name
- NCT00188201
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Hepatitis C, Hepatitis B
Insulin Resistance Associated With Chronic Hepatitis C (CHC) and the Effect of Antiviral Therapy
The literature suggests that there may be an association between hepatitis C and type 2 diabetes mellitus independent of the presence of cirrhosis, the likely mechanism for which is insulin resistance.
- Trial name
- NCT00188240
- Testing
- Pegasys; Copegus.
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Lymphoma, Lymphoma, Non-Hodgkin
Ultrasound Biomicroscopy - Apoptosis
A group of researchers at the Ontario Cancer Institute/Princess Margaret Hospital have discovered that a very specific form of cell death 'apoptosis' can be detected using high-frequency ultrasound imaging.
- Conditions
- Lymphoma, Lymphoma, Non-Hodgkin, Melanoma, Carcinoma, Basal Cell
- Trial name
- NCT00188370
- Testing
- high frequency ultrasound imaging
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Bipolar Disorder
Psychoeducation Versus Cognitive-Behavioral Therapy in Bipolar Disorder
To examine the impact of cognitive-behavioural therapy on both the episodic and functional outcome of bipolar disorder, in combination with pharmacotherapy. Primary Hypothesis is twofold: 1.
- Trial name
- NCT00188838
- Testing
- Psychoeduction, Cognitive-Behavioral Therapy
- Where
- 6 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
HIV
Structured Treatment Interruption for HIV Patients With Virologic Failure
The purpose of this study is to assess the virologic impact of switching treatment-experienced HIV-infected patients with virologic failure to a salvage regimen with or without a 12 week STI prior to the switch.
- Trial name
- NCT00188851
- Testing
- therapeutic management strategy
- Volunteers
- 196 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Diet and Breast Cancer Prevention Trial
This randomized controlled trial tests the hypothesis that a reduction in intake of dietary fat will reduce the incidence of breast cancer.
- Trial name
- NCT00148057
- Testing
- Low-fat diet
- Where
- Canada
- Volunteers
- 4,695 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto