Clinical trials: completed, sponsored by University Health Network, Toronto
Type 2 Diabetes Mellitus
Incretin and Treatment With Inhibition of Sodium-glucose Cotransporter-2 Combination Insights Into Mechanisms Implicated in Congestive Heart Failure: "NATRIURETIC" Trial
This study aims to provide essential mechanistic insights into natriuretic and hemodynamic effects of SGLT2i and GLP-1RA agents in T2D patients.
- Trial name
- NATRIURETIC (NCT04535960)
- Testing
- Empagliflozin 25 MG + Liraglutide 1.8 MG, Liraglutide 1.8 MG + Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Head and Neck Squamous Cell Carcinoma
Head and Neck Squamous Cell Carcinoma (HNSCC)PET-CT Pilot Study
The purpose of this study is to see how useful the information provided from Positron Emission Tomography (PET) scans can be in the actual planning and delivery of radiation treatment to patients who have head and neck cancers.
- Trial name
- NCT02678884
- Testing
- 18-F FDG
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University Health Network, Toronto
Locoregionally-advanced Oropharyngeal Squamous Cell Carcinoma
Role of Microbiome as a Biomarkers in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma
This is a minimal risk feasibility study involving the analysis of patient samples and does not involve any therapeutic intervention.
- Trial name
- ROMA LA-OPSCC (NCT03759730)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Study of CFI-400945 Fumarate in Patients With Relapsed or Refractory AML or MDS
This is a phase 1 study of investigational drug CFI-400945 in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic syndrome.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndromes, Relapsed Cancer, Refractory Cancer
- Trial name
- NCT03187288
- Testing
- CFI-400945 Fumarate
- Where
- 2 sites in Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
Neuroendocrine Tumors
Lu-DOTATATE Treatment in Patients With 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors
This is a prospective single arm, multicenter study will evaluate the efficacy and safety of Lutetium-177 Octreotate in patients with neuroendocrine tumors who has positive Somatostatin receptor identified by 68Ga-DOTATATE.
- Trial name
- NCT02743741
- Testing
- Lutetium-177 Octreotate
- Where
- 4 sites in Canada
- Volunteers
- 195 people
- Sponsor
- University Health Network, Toronto
Gynecologic Cancer
Impact of Cultural and Linguistic Backgrounds on Patient Care and Experience of Women With Gynecologic Malignancies
Purpose of this study to delineate the attitudes and experiences of patients, interpreters and cancer care professionals involved in the care of oncology patients with gynecologic malignancies with cultural and linguistic…
- Trial name
- iCALD-2 (NCT05971303)
- Testing
- Questionnaire
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Laparoscopic Cholecystectomy
AI and Safety in Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Today, the majority of gallbladder removals surgeries are done using minimally invasive techniques through small cuts to help patients recover faster.
- Trial name
- NCT07186803
- Testing
- Artificial Intelligence Guidance Models
- Where
- 2 sites in Canada
- Volunteers
- 64 people
- Sponsor
- University Health Network, Toronto
Pain Management
Erector Spinae Plane (ESP) Block Volunteer Study
Although erector spinae plane (ESP) block reportedly provides postoperative pain relieve, controversy remains regarding the accuracy and consistency of analgesic success following ESP block.
- Trial name
- NCT04401007
- Testing
- Erector Spinae Plane Block with 1.5% lidocaine
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Chronic Pain, Opioid Use
Improving Pain Disability With the Use of Oral Cannabinoids
The investigators are conducting a pilot (i.e. a small study) in order to find out the effectiveness and safety of medical cannabis in the management of chronic pain.
- Conditions
- Chronic Pain, Opioid Use, Cannabis
- Trial name
- NCT05351905
- Testing
- CBD oil ( MPL-001), CDB+THC oil (MPL-005)
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- University Health Network, Toronto
Concussion
Oculomotor Rehabilitation After Concussion in Adults: A Feasibility Study
After concussion, many individuals experience vision-related symptoms such as blurred vision, difficulty reading, and discomfort in visually stimulating environments, which can interfere with return to work, school, and daily…
- Trial name
- ORCA (NCT07709936)
- Testing
- Usual Care, Oculomotor exercises delivered in virtual reality
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Head and Neck Cancer, Melanoma
Selection Pressure and Evolution Induced by Immune Checkpoint Inhibitors and Other Immunologic Therapies
Two part prospective study to: 1. investigate the feasibility of performing ultra-deep sequencing of plasma derived circulating tumor DNA (ctDNA) in individual patients with advanced solid tumors who are currently being treated…
- Trial name
- SPECIAL (NCT02724488)
- Volunteers
- 14 people
- Sponsor
- University Health Network, Toronto
Pancreatic Cancer
Study of Intratumoral Hypoxia Using Pre-operative Administration of Pimonidazole
This study involves the administration of a hypoxia marker, pimonidazole hydrochloride, taken orally approximately 24 hours before surgical resection of a pancreatic tumor in order to identify areas of lower oxygen content on…
- Trial name
- NCT01248637
- Testing
- Pimonidazole hydrochloride
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Pancreatic Cancer
A Study of Gemcitabine/Nab-paclitaxel and Radiation Therapy Followed by Surgery in Patients With Advanced Pancreatic Cancer
This is a phase 1 (the first phase in testing a new drug, to see how safe a new drug or new indication/population ) and phase 2 (the second phase in testing a new drug or new indication/population to see how effective the drug…
- Trial name
- NCT02481635
- Testing
- Gemcitabine, Nab-paclitaxel, Radiation Therapy
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Advanced Solid Cancers, Breast Cancer
A Study of Investigational Drug CFI-402257 in Patients With Advanced Solid Tumors
This is a phase 1 study of investigational agent CFI-402257 in patients with advanced cancer. The purpose of this study is to see how safe and tolerable CFI-402257 is in cancer patients as well as the pharmacokinetics (PK).
- Trial name
- NCT02792465
- Testing
- CFI-402257, Fulvestrant
- Where
- 3 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University Health Network, Toronto
Small Cell Carcinoma, Hypercalcaemic Type, Ovarian Cancer
Pembrolizumab in Small Cell Carcinoma of Ovary - Hypercalcemic Type Patient
This is a study of pembrolizumab as consolidation therapy for a patient with small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).
- Trial name
- Pemb-HT (NCT05368207)
- Testing
- Pembrolizumab
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Respiratory Insufficiency, Diaphragm Injury
Diaphragm Injury and Dysfunction During Mechanical Ventilation
This study is designed to evaluate the relationship between diaphragm activity during mechanical ventilation and the development of ventilator-induced diaphragm dysfunction (VIDD).
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Mechanical Ventilation Complication
- Trial name
- MYOTRAUMA (NCT03108118)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Diaphragm Injury, Weaning Failure
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
This study is designed to determine whether maximal diaphragm thickening fraction measured by ultrasound during volitional maximal inspiratory efforts is a valid measure of diaphragm function in mechanically ventilated patients.
- Conditions
- Diaphragm Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- SNIFF III (NCT03129217)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University Health Network, Toronto
Non-squamous Non-small-cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Study of Crizotinib for ROS1 and MET Activated Lung Cancer
This is a phase 2 study of a drug called crizotinib in people with metastatic (the cancer has spread to other parts of the body) non-small cell lung cancer with a mutation (change) in genes called ROS1 or MET.
- Conditions
- Non-squamous Non-small-cell Lung Cancer, Stage IV Non-small Cell Lung Cancer, ROS1 Gene Rearrangement, MET Activating Mutation
- Trial name
- NCT04084717
- Testing
- Crizotinib
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- University Health Network, Toronto
Acute Respiratory Failure, Respiration, Artificial
Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation
This study will evaluate the heart, lungs and diaphragm of patients who fail a trial of spontaneous breathing to determine the physiological mechanism of weaning failure.
- Conditions
- Acute Respiratory Failure, Respiration, Artificial, Weaning
- Trial name
- USEFUL (NCT02723565)
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Diaphragm
Defining the Normal Range for Maximal Sniff Diaphragm Thickening Fraction
This study is investigating the normal range of maximal diaphragm thickness during a sniff inspiratory manoeuvre using ultrasound in healthy subjects stratified by age and gender.
- Trial name
- SNIFF II (NCT03129386)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto