Clinical trials: sponsored by University Hospital, Angers
Gastroschisis, Intestinal Occlusion
Prospective Study of Antenatal Diagnostic Criteria for Digestive Complications of Gastroschisis
Gastroschisis is a rare congenital malformation consisting in a right para-umbilical defect of the abdominal wall leading to an evisceration of the abdominal content.
- Trial name
- LaparoDAN (NCT04174807)
- Where
- 36 sites in France, Martinique
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Healthy
Evaluation in Healthy Volunteers of CARDIOSPACE II
The aim of this project is to test the CARDIOSPACE II system that integrates several medical devices. This system is dedicated to physiological studies in space environment.
- Trial name
- CDSII (NCT04205032)
- Testing
- Test of the different devices integrated in cardiospace II
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Parkinson Disease
Feasibility Study of the Taïso Practice in Parkinson's Disease
This is a pilot study of descriptive and analytical, prospective feasibility, monocentric, longitudinal with 6 months of bi-weekly practice of Taïso in patients with Parkinson's disease with mild to moderate postural instability.
- Trial name
- Taïso-Park (NCT04045925)
- Testing
- Taïso
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Angers
Mild Cognitive Impairment
Study of Motor Representations in Healthy Subjects and Amnestic MCI
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.
- Trial name
- IRMARCHE (NCT02574182)
- Testing
- Brain MRI
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Peripheral Artery Disease, Claudication, Intermittent
Lactate Increase in Peripheral Artery Disease
To our knowledge, the measurement of the transcutaneous oxygen pressure during walking is the only continuous method that estimates the importance of ischemia, bilaterally and segment of limb by segment of limb.
- Trial name
- STELLA (NCT03266861)
- Testing
- Exercise oximetry
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Angers
Acute Myeloid Leukemia
Outcome of Patients With CBF and/or NPM1-mutated AML in First Molecular Relapse.
Despite good initial response, some patients with core binding factor and/or NPM1-mutated AML eventually relapse. Some of these patients can be identified earlier on, before overt cytological relapse, when followed for minimal…
- Trial name
- MOLAM (NCT04931992)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Thoracic Outlet Syndrome
Clinical Routine in Thoracic Outlet Syndrome
Transversal recording and analysis of investigations performed in patients referred for suspected thoracic outlet syndrome (TOS)
- Trial name
- SKIPA (NCT04376177)
- Testing
- Ultrasound, angiography, questionnaires
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Angers
Peripheral Arterial Disease
Evaluation of Muscle Ischemia in Arterial Claudication (Tsingtao)
The goal is to compare the results observed in patients that had both an exercise oximetry and a thallium scintigraphy for lower limb claudication
- Trial name
- Tsingtao (NCT04911595)
- Testing
- exercise oximetry, thallium scintigraphy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Critical Limb Ischemia
Critical Limb Ischemia and Transcutaneous Oximetry
Retrospective analysis of transcutanesou oximetry (Tcpo2) recording for patients referred with suspected critical limb ischemia searching for specific changes in TcpO2 patterns.
- Trial name
- CITRA (NCT04369781)
- Testing
- transcutaneous oxygen pressure recording at rest
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Renal Stone, Ureteral Stone
Effectiveness of Holmium and Thulium Lasers With Ureteroscopy for Urinary Lithiasis
Holmium laser is the current gold standard for lithotripsy on urinary lithiasis, while Thulium is brand new. The latter has been released in July 2020 in Europe, and only in-vitro studies have been published.
- Trial name
- LiThuHol (NCT04871984)
- Testing
- Ureteroscopy for upper tract stone treatment with Holmium laser, Ureteroscopy for upper tract stone treatment with Thulium laser
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Coronavirus
COvid-19 and Vitamin D Supplementation: a Multicenter Randomized Controlled Trial of High Dose Versus Standard Dose Vitamin D3 in High-risk COVID-19 Patients (CoVitTrial)
Vitamin D is a secosteroid hormone produced by the skin during Summer exposure to UVB rays. Hypovitaminosis D is common in Winter (October to March) at Northern latitudes above 20 degrees North, and from April to September at…
- Trial name
- NCT04344041
- Testing
- cholecalciferol 200,000 IU, cholecalciferol 50,000 IU
- Where
- 9 sites in France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Angers
Diaphragmatic Eventration
Diaphragmatic Eventration in Children : Evaluation of Care Strategies and Results in the French Cohort.
A diaphragmatic eventration is an abnormal and permanent elevation of a portion or an entire intact hemidiaphragm. This rare pathology, found in 0.2 - 1 for every 1000 patients in large radiological series, is either congenital…
- Trial name
- PedDiaVen (NCT04862494)
- Testing
- clinical surveillance, diaphragmatic plication
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Coagulation; Intravascular, Craniocerebral Trauma
PREVACT : Preventive REversal of Vitamine K Antagonist in Minor Craniocerebral Trauma
The occurence of a minor craniocerebral trauma in patients receiving vitamine K antagonist treatment leads to a high risk of bleeding.
- Conditions
- Coagulation; Intravascular, Craniocerebral Trauma, Haemorrhage
- Trial name
- PREVACT (NCT01961804)
- Testing
- Reversion
- Where
- 21 sites in France
- Volunteers
- 202 people
- Sponsor
- University Hospital, Angers
Quality of Recovery, Perioperative Complication
Validation of the QoR-15 Score for Emergency Surgery
Recovery from surgery is a complex process, depending on the characteristics of the patient, the anesthesia used, and the time required for surgical management.
- Conditions
- Quality of Recovery, Perioperative Complication, Anesthesia, Patient Reported Outcome Measures
- Trial name
- FQoR-15U (NCT04845763)
- Testing
- FQoR-15 questionnaire
- Volunteers
- 375 people
- Sponsor
- University Hospital, Angers
Detection of Liver Metastases
Detection and Automatic Segmentation of Liver Nodules in Patients With Colorectal Adenocarcinoma
Evaluation of the diagnostic performance of artificial intelligence-based software for the detection of liver nodules on scanner in patients at risk of liver metastases of colorectal cancer
- Trial name
- OOPS (NCT04834596)
- Testing
- retrospectives analysis on hepatic scanner
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Coronavirus Infection
Hospitalization or Outpatient ManagEment of Patients With SRAS-CoV-2 Infection - Revised HOME-CoV Score Study
In the context of COVID-19 pandemic, identifying low-risk patients who can be safely treated at home and high-risk patients requiring hospitalization or even intensive care is crucial for Emergency Departments.
- Trial name
- NCT04657471
- Testing
- revised HOME-CoV score
- Where
- France
- Volunteers
- 1,300 people
- Sponsor
- University Hospital, Angers
Bariatric Surgery Candidate, Obesity, Morbid
Adolescents Bariatric Surgery Cohort Survey
Obesity affects 3%-4% of the pediatric population and leads to cardiac mortality during adult life. Bariatric surgery is the best treatment for weight loss and preventing obesity associated comorbidities in adults, but its…
- Conditions
- Bariatric Surgery Candidate, Obesity, Morbid, Obesity, Adolescent
- Trial name
- BariAdo (NCT04766801)
- Testing
- Laparoscopic adjustable gastric banding
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Delivery, Childbirth
Translation and Validation of the French Version of the ObsQoR-10 Questionnaire
Until recently, there was no validated scoring tool to assess recovery after childbirth. Ciechanowicz et al. developed and validated a postpartum recovery score for women with a caesarean section (scheduled or unscheduled): the…
- Conditions
- Delivery, Childbirth, Patient Reported Outcome Measures, Labor Complication
- Trial name
- ObsQoR-10F (NCT04489602)
- Testing
- ObsQoR-10F Questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
Hepatocellular Carcinoma
Comparison of Multiphase and Monophasic Arterial Hepatic MRI in the Detection of Arterial Enhancement of CHC Nodules
The detection and diagnosis of hepatocellular carcinoma is a public health issue. MRI is the most sensitive examination for diagnosis and especially hypervascularization in the arterial phase.
- Trial name
- CHIC MultiA (NCT04687280)
- Testing
- non interventional
- Volunteers
- 153 people
- Sponsor
- University Hospital, Angers
Bleeding Esophageal Varices, Cirrhosis
Prognostic Value of Measuring DsAz by MRI in Cirrhotic Patients on Prophylactic Treatment With β Blocker (AzyMR)
Portal hypertension (PHT) that leads to esophageal varices is clinically present, at the time of diagnosis, in 60% of cirrhotic patients (Groszmann NEJM 2005). Variceal bleeding is a life-threatening complication.
- Trial name
- AzyMR (NCT02475122)
- Testing
- azygos blood flow measurements by MRI
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Angers