Clinical trials: sponsored by University Hospital, Angers
Mechanical Ventilation
Evaluation of the Hemodynamic Effects of Transvenous Phrenic Stimulation
Mechanical ventilation is a cornerstone in the management of severe forms of pneumonia, acute respiratory distress syndrome. It provides essential oxygen to patients, ventilates the lungs but also has deleterious effects like any…
- Trial name
- HEMOSTIM (NCT04680351)
- Testing
- phrenic stimulation
- Where
- 3 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Angers
Hepatocellular Carcinoma
MR Quality + Diagnostic Performance for CHC Diagnosis - Gadoxetic Acid, Gadoteric Acid and P03277 Comparison
Compare diagnostic MRI performance of gadoteric acid, gadoxetic acid and P03277 for suspected CHC nodules less than 3 cm, using LIRADS criteria
- Trial name
- NCT04652947
- Testing
- MRI diagnostic
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Mechanical Ventilation, Prehospital Capnography Monitoring
Identification of Risk Factors for Alteration of the Cellular-arterial Gradient of CO2
Monocentric, prospective, observational and descriptive study on the evaluation of risk factors for alteration of the alveoarterial gradient of CO2 in pre-hospital patients, intubated and then ventilated in an invasive manner…
- Trial name
- DELTA-CAPNO (NCT04489615)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Medulloblastoma, Childhood, Healthy Volunteers
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized…
- Conditions
- Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
- Trial name
- CervIRM (NCT04174820)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- 5 sites in France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Hip Fracture Surgery
Predicted Level of General Anaesthesia in Hip Fracture Surgery
The purpose of this study is to evaluate if prediction of general anaesthesia level by the Smartpilot® View device can improve the quality of anaesthesia in patients undergoing hip fracture surgery.
- Trial name
- NAPfem (NCT02556658)
- Testing
- General anesthesia managed by the Smartpilot® View, General anesthesia managed without the Smartpilot® View
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Satisfaction, Personal, Anesthesia
PEPPER : PErcePtion of Pre-anesthesia Visit With or Without Robot
Pre-anesthesia visit for scheduled surgery is mandatory by law in France. During this visit, patients should be informed of the different available technics of anesthesia (i.e. general or loco-regional) and of their own risks .
- Trial name
- PEPPER (NCT03521453)
- Testing
- PEPPER robot
- Where
- France
- Volunteers
- 298 people
- Sponsor
- University Hospital, Angers
Intensive Care Units
ORI2 : ORI for hyperOxia Reduction in ICU
Recently, hyperoxia has been recognized as being potentially deleterious for critically ill patients, with increased duration of mechanical ventilation and even with increased mortality rates.
- Trial name
- ORI2 (NCT02878460)
- Testing
- monitoring with ORI + SpO2, monitoring with SpO2
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Hemofiltration, Nurse Training
Simulation for Continuous Veno-venous Hemofiltration in Intensive caRe
Continuous Veno-Veinous Hemofiltration (CVVH) is a frequently used renal replacement therapy in intensive care units for patients with acute renal failure. In theory, this therapy should be continuous, 24 hours/day.
- Conditions
- Hemofiltration, Nurse Training, Health Care Provider Education
- Trial name
- SIMHeR (NCT02379234)
- Testing
- simulation
- Where
- France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Angers
Mitochondrial Diseases
Executive Function Disorders and Anxio-depressive Symptomatology in Children and Adolescents With Mitochondrial Pathologies
The major steps forward of the neurosciences in recent years have linked psychiatric diseases, neuropsychological symptoms and brain dysfunctions.
- Trial name
- MITOPSY (NCT03832218)
- Testing
- Psychiatric assessment
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Angers
Presymptomatic Huntington Disease
Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing
The purpose of this study is to assess the psychological, cognitive and social resources of applicants for Huntington's Disease and Presymptomatic Testing.
- Trial name
- PREHUNT (NCT02134561)
- Testing
- psychological interview, MRI, cognitive tests
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Angers
Huntington's Disease
Social Cognition in Huntington's Disease: Cognitive Study and Functional and Morphological Imaging
Huntington's disease is a rare genetic neurodegenerative disease. It is accompanied by movement disorders, cognitive and behavioral. The social behavior of patients are changed, affecting interpersonal relationships.
- Trial name
- COSIMH (NCT02550275)
- Testing
- neuropsychological test, MRI
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Huntington Disease
Behavioural Problems in Huntington Disease : Analysis and Enhancement of Caregiver and Patient Experience
The study hypothesis is that caregivers experience allows them to develop a lot of knowledge and know-how about behavioural problems in Huntington Disease and its consequences.
- Trial name
- HUNTEXPERT (NCT02218567)
- Testing
- questionnaire qualilty of life, psychological interview, psychological tests
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Coronavirus
Hydroxychloroquine Versus Placebo in COVID-19 Patients at Risk for Severe Disease
A new human coronavirus responsible for pneumonia, SARS-CoV-2, emerged in China in December 2019 and has spread rapidly. COVID-19, the disease caused by this virus, has a very polymorphous clinical presentation, which ranges from…
- Trial name
- HYCOVID (NCT04325893)
- Testing
- Hydroxychloroquine
- Where
- 47 sites in France, Monaco
- Volunteers
- 259 people
- Sponsor
- University Hospital, Angers
Peripheral Arterial Disease
Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking
The prevalence of peripheral arterial disease (PAD) is greater than 15%. PAD is associated with an increased risk of cardiovascular death, coronary heart disease and stroke, with a mortality rate of 5% per year.
- Trial name
- First-BLINDOS (NCT03615833)
- Testing
- Cholecalciferol
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Angers
Psychological
Resilience Evaluation of Caregivers During the SARS-CoV2 Epidemic Period : Prospective Cohort.
The outbreak linked to SARS-CoV-2 infection was declared a Public Health Emergency of International Concern on 30 January 2020. In all of the emergency Departments, a major reorganization was necessary, notably with the creation…
- Trial name
- Resi-CoV (NCT04349163)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Emergency Medicine
Healthcare Renunciation During the Confinement Period in Connection With the COVID-19 Epidemic in Adult Emergency Departments
Healthcare renunciation is defined as: "Individuals give up care when they do not seek services and health care professionals when they experience a disorder, experience a physical or mental disorder, or when they do not access…
- Trial name
- NCT04460196
- Testing
- survey
- Where
- 2 sites in France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Angers
Coronavirus Infection
HOME-CoV: Hospitalization or Outpatient ManagEment of Patients With a SARS-CoV-2 Infection
COVID-19 pandemic has developed worldwide in less than 4 months. The clinical presentations are variable widely, ranging from simple rhinitis to major lung damage that can lead to death.
- Trial name
- HOME-CoV (NCT04338841)
- Testing
- HOME-CoV rule implementation
- Where
- 29 sites in Belgium, France and 1 more
- Volunteers
- 3,133 people
- Sponsor
- University Hospital, Angers
Gait Apraxia, Alzheimer Disease
Comparisons of gaIt aNalyses pERformance Between the Gaitrite walkwaYs
The GAITRite® system is an instrumented with resistive pressure sensors gait analyzer. It was first validate in 2001 against paper-and-pencil (intraclass correlation coefficient [ICC] > 95%) for spatial measures and against…
- Conditions
- Gait Apraxia, Alzheimer Disease, Impaired Cognition
- Trial name
- CINERGY (NCT04557592)
- Where
- France
- Volunteers
- 98 people
- Sponsor
- University Hospital, Angers
Peripheral Artery Disease
Claudication, Systematic Evaluation of Limp on Treadmill
Vascular claudication is a common cause of functional limitation. This painful condition is a source overall muscle deconditioning in the peripheral arterial diseased (PAD) patient leading gradually to a state accented…
- Trial name
- CLAUSEL (NCT02754804)
- Testing
- Biomechanic parameters
- Where
- France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Angers
Other Diseases of Veins and Lymphatics
ACCUvein Measure Before ULtrasound as A facilitataTION Tool for Venous Marking
Ultrasound marking of saphenous veins before varicose vein surgery or for saphenectomy for vascular or coronary artery bypass grafting is a long, tedious, low-grading examination, generating overconsumption of many consumables…
- Trial name
- ACCUMULATION (NCT03538080)
- Testing
- ACCUVEIN plus ultrasound, Ultrasound only
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers