Clinical trials: sponsored by University Hospital, Angers
Acute Respiratory Distress Syndrome
Early Spontaneous Breathing in Acute Respiratory Distress Syndrome
The care of acute respiratory distress syndrome (ARDS) has been significantly improved by learning from experimental and physiological research works and by a series of randomized controlled trials.
- Trial name
- BiRDS (NCT01862016)
- Testing
- APRV, arterial blood gas measurement each morning
- Where
- France
- Volunteers
- 702 people
- Sponsor
- University Hospital, Angers
Vascular Prosthesis Infection
Study Assessing Hybrid SPECT-CT With Labeled Leukocytes for Diagnosis of Vascular Prosthesis Infections
Vascular Prothesis Infection is a rare but an extremely serious complication. Diagnosis is often difficult (germs are found only in 50% of cases).
- Trial name
- LEUCOPRO (NCT02538133)
- Testing
- 99mTc-Exametazime (HMPAO)-labeled leukocytes
- Where
- 3 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Pseudoxanthoma Elasticum
Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study)
This study aims to demonstrate a potential association between gut microbiota composition, plasma levels of various forms of vitamin K, and severity of clinical manifestations of Pseudoxanthoma Elasticum (PXE).
- Trial name
- IMPROVE (NCT03813550)
- Testing
- Fecal and blood samples
- Where
- 3 sites in France, Netherlands
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Acute Small Intestine Obstruction
Small Bowel Obstruction and Surgery
Postoperative management after small bowel obstruction (SBO) surgery is not consensual and better knowledge of risk factors for postoperative morbidity could help to add evidence of the feasibility of enhanced recovery programs…
- Trial name
- NCT03826251
- Testing
- Nasogastric tube removal
- Volunteers
- 190 people
- Sponsor
- University Hospital, Angers
Sleep Apnea, Obstructive
Microparticles in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is independently associated with cardiovascular diseases, including myocardial infarction and stroke.
- Trial name
- BioSAS (NCT03438149)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Non-alcoholic Fatty Liver Disease, Sleep Apnea, Obstructive
Obstructive Sleep Apnea and Non-alcoholic Fatty Liver Disease
Obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in patients with metabolic syndrome (MS). Several data suggest that OSA per se could be a risk factor of liver injury.
- Trial name
- NASHSAS (NCT03373643)
- Testing
- OSA screening
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Peripheral Arterial Occlusive Disease
Efficacy of Sildenafil on the Morbi-mortality of Peripheral Arterial Diseased Patients With Intermittent Claudication
Peripheral Arterial Disease (PAD) is a highly debilitating disease that affects 202 million people around the world and about 7 million people in France. Morbi-mortality from cardiovascular events is increased in this population.
- Trial name
- VALSTAR (NCT02930811)
- Testing
- Sildenafil 100 mg oral morning dose
- Sponsor
- University Hospital, Angers
Peripheral Artery Disease
Evaluation of Patients With Suspected Endofibrosis
Define responses to exercise on both arterial bruits and oxymetry in patients referred for suspected endofibrosis.
- Trial name
- Stethosport (NCT02501694)
- Testing
- Auscultation
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Infertility, Oocytes
Efficacy of a Simulator Based (PickUpSimTM) Residents' Training Program for Oocyte Retrievals
Simulation is an educational approach that has recently found an application in healthcare.acquire. Angers university hospital has decided to acquire, in December 2016, the high-fidelity Oocyte Pick up (OPU) simulator…
- Conditions
- Infertility, Oocytes, Fertilization in Vitro
- Trial name
- NCT03700255
- Testing
- PickUpSimTM simulation training program
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Recurrent Pregnancy Loss, Recurrent Implantation Failure
Use of Metabolomics for the Identification of Endometrial Biomarkers for IRPL and RIF After in Vitro Fertilization
It is a case-control study composed of 3 groups : 2 cases groups (RIF and IRPL) already composed as part of a pre-existing research project and 1 control group including patients undergoing ART for male factor infertility.
- Trial name
- ENDOMETAB (NCT03690830)
- Testing
- metabolomics analysis
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Endometriosis
Assessment of Performance of [18F]-FES for Endometriosis Diagnosis
Endometriosis is a benign chronic disease responsible for infertility and pelvic pain. One of the main problem of endometriosis is the significant delay of diagnosis.This delay has significant consequences for patients.
- Trial name
- ENDOTEP (NCT02233621)
- Testing
- [18F]FES (16α-[18F]Fluoro-17β-estradiol)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Angers
Embryo Transfer, Infertility
Comparison of Vaginal and Transdermal Oestrogen Before Frozen Thawed Embryo Transfer
The purpose of this study is to compare pregnancy outcomes of frozen-thawed embryo transfer after endometrial preparation with vaginal estradiol or transdermal estradiol and to evaluate women's satisfaction
- Trial name
- NCT03518528
- Testing
- Estradiol 2 MG, Estradiol 100 µg
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Geriatric Disorders
GeRIatric Multidisciplinary Meeting
The primary objective of this study is to develop a typology of patients referred to the Geriatric Multidisciplinary Meeting (GMM) according to their demographic and clinical profile.
- Trial name
- GRIMM (NCT03579056)
- Where
- France
- Volunteers
- 734 people
- Sponsor
- University Hospital, Angers
Colorectal Cancer
Pilot Study in a Company in Maine-et-Loire to Evaluate the Feasibility, Acceptability, and Impact on the Participation Rate of Awareness of Colorectal Cancer Screening by Occupational Health Teams
The main objective of this pilot study is to implement an awareness campaign for colorectal cancer screening in the workplace, in partnership with the staff of the occupational health service of one of the largest companies in…
- Trial name
- NCT03458949
- Testing
- awareness campaign
- Where
- France
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Pseudoxanthoma Elasticum
What's Happen Under the Calcification Process in Pseudoxanthoma Elasticum
The investigators hypothesize is that in PXE patients, low grade chronic inflammation could preceed the molecular and the clinical calcification process.
- Trial name
- GOCAPXE (NCT03070860)
- Testing
- PET scan 18-FDG and 18-NAF
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Angers
Renal Insufficiency, Contrast Medium-induced Renal Insufficiency
Renal PRotection Against Contrast mEdium-induced nephroPathy in High Risk Patients undErgoing Coronary Angiography
This study evaluates the efficacy of remote ischemic preconditioning on preventing contrast medium-induced nephropathy in a population of high risk patients undergoing coronary angiography.
- Trial name
- PREPARE (NCT02463604)
- Testing
- Coronary Angiography
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Angers
Hyperthyroid
Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy
1. MAIN OBJECTIVE : To assess the consequences of a maternal hyperthyroïd during pregnancy on intellectual development of the child from 6 to 9 years 2. SECONDARY OBJECTIVES : 1.
- Trial name
- EDIEMHYPER (NCT01779817)
- Testing
- Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years.
- Where
- 13 sites in France
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Lower Limb Injury, Pulmonary Embolism
Assessment of the Impact of TIP Score on Thromboprophylaxis in Patients With Non-surgical Lower Leg Trauma.
Traumatic lesions are the leading causes of admission to the emergency center (39%), isolated non-surgical lower limbs trauma are in the foreground.
- Conditions
- Lower Limb Injury, Pulmonary Embolism, Venous Thromboses
- Trial name
- EvaTIP (NCT03089255)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Angers
Dinoprostone Vaginal Insert
Assessing a Predicted Time to Delivery in the Context of Cervical Ripening With Dinoprostone Vaginal Insert
Induction of labor is a common obstetric procedure that is routinely performed worldwide. However, when cervical conditions are not favorable (bishop <6), induction of labor is preceded by cervical ripening, usually with…
- Trial name
- NCT03482531
- Testing
- mathematical model
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Primary Antiphospholipid Syndrome
Hydroxychloroquine Versus Placebo: Impact on Thrombotic Relapse in Primary Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) combines thrombotic (venous and/or arterial) and/or obstetrical manifestations, along with biological anomalies related to the presence of antiphospholipid antibodies.
- Trial name
- PAPIRUS (NCT03540810)
- Testing
- Hydroxychloroquine
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers