Clinical trials: sponsored by University Hospital, Angers
Sporadic Amyotrophic Lateral Sclerosis
Bioenergetics and Protein Metabolism in Sporadic Amyotrophic Lateral Sclerosis
INTRODUCTION: Amyotrophic Lateral Sclerosis (ALS) is a degenerative disease of the motor neurones of the brain and the spinal cord. The pathophysiological mechanisms of the disease remain unknown.
- Trial name
- Fibro-ALS (NCT02969759)
- Testing
- Skin Biopsy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Gait Variability; Elders; Fall; Re-education
Effect of Observation Plus Imagination of Gait on Stride Variability in Young and Older Adults
The aim of study is to examine the combined effect of observation and imagination of gait on stride time variability of stride time among in healthy young and older adults.
- Trial name
- OBI (NCT02120144)
- Testing
- Observation & imagination, Reading
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Alzheimer Disease
Alzheimer's Disease - Input of Vitamin D With mEmantine Assay
The purpose of this study is to compare the effect after 24 weeks of the oral intake of vitamin D3 (cholecalciferol) with the effect of a placebo on the change of cognitive performance in patients suffering from moderate…
- Trial name
- AD-IDEA (NCT01409694)
- Testing
- Memantine, Vitamin D
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Angers
Gait Apraxia, Alzheimer Disease
Gait and Alzheimer Interaction Tracking (GAIT) Study
The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and…
- Conditions
- Gait Apraxia, Alzheimer Disease, Impaired Cognition, Cerebral Atrophy
- Trial name
- GAIT (NCT01315717)
- Where
- France
- Volunteers
- 912 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Pulmonary Embolism, Dyspnea
PERCEPIC: PERC Rule Combined With Implicit Low Clinical Probability
PERC rule was created to rule out pulmonary embolism (PE) without further exams, with residual PE risk <2%. Its safety is currently confirmed in low PE prevalence populations as north-American.
- Conditions
- Pulmonary Embolism, Dyspnea, Thoracic Pain
- Trial name
- PERCEPIC (NCT02360540)
- Testing
- Gestalt estimation
- Where
- 12 sites in Belgium, France
- Volunteers
- 1,773 people
- Sponsor
- University Hospital, Angers
Memory Complaint Without Cognitive Decline
GAit, MEmory, Dietary and Vitamin D
Gait and posture disorders are very common in subjects aged 65 and over, and result mainly from neuromuscular and cognitive disorders.
- Trial name
- GAME-D2 (NCT02086409)
- Testing
- Yogurt supplemented with vitamin D and calcium, Yogurt not supplemented with vitamin D and calcium
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Elderly
Physical Activity and Fall Prevention in Geriatric Inpatients in Acute caRe: Feasibility Study
This study aims to evaluate the feasibility and the impact on physical performance and falls occurence among geriatric inpatients hospitalized in acute care unit.
- Trial name
- AGIR (NCT02393014)
- Testing
- Simple physical exercises
- Where
- France
- Volunteers
- 278 people
- Sponsor
- University Hospital, Angers
Thrombopenia, Central Venous Catheter Placement
Platelet Kinetics After Platelet Transfusion for the Placement of a Central Venous Catheter
PLATCAT study's purpose is to evaluate platelet kinetics after platelet transfusion
- Trial name
- PLATCAT (NCT02906878)
- Testing
- Platelets transfusion
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Acute Pain
Morphine Titration by Patient Self-controlled by a Mechanical Device Versus Administration by the Nurse for Patients With Severe Acute Pain in the Emergency Department
Intense acute pain is a common reason for Emergency admittance and its management is one of the major public health goals. In the recommendations formalized experts, it is recommended to use a protocol titration with morphine…
- Trial name
- TACIDOU (NCT02152176)
- Testing
- Titration of morphine by Patient Controlled Analgesy
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Colorectal Cancer
Impact of DietarY and LIfestyle Risk Factors on Colorectal Cancer Screening
The main purpose of our project is to construct a lifestyle score based on a short questionnaire easy to complete and to validate it among participants in mass screening for colorectal cancer in Maine and Loire department over…
- Trial name
- IDYLIC (NCT02804802)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 49,000 people
- Sponsor
- University Hospital, Angers
Pain
Pain Impact Assessment of the Relational Touch During Arterial Puncture in ICU (TORREA)
Study objective is to assess the interest of the relational touch before an arterial puncture to reduce pain on patient in intensive care unit.
- Trial name
- ToRRéa (NCT02684149)
- Testing
- relational touch
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Angers
Lymphoma
Impact of Socio-aesthetic Care in the Quality of Life of Patients Treated for Lymphoma During and After Hospitalization
In the early 2000s , professional and patient organizations are mobilizing to highlight the psychosocial impact of cancer disease , not only during but also after the acute phase.
- Trial name
- CareSSE (NCT02072655)
- Testing
- socio-aesthetic care
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Microvascular Function
Methodological Issues and Laser Speckle Contrast Imaging
Microcirculation, especially skin microcirculation, is a window towards systemic vascular function in magnitude and underlying mechanisms. Different techniques have been developed to assess the microcirculation.
- Trial name
- METHODO-LSCI (NCT01664572)
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Morbidly Adherent Placenta, Placenta Accreta
Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta
The purpose of this study is to determine whether, in a high risk population (placenta praevia and previous caesarean or prenatal suspicion of morbidly adherent placenta (MAP)), the concentration of cell-free fetal DNA…
- Conditions
- Morbidly Adherent Placenta, Placenta Accreta, Placenta Increta, Placenta Percreta
- Trial name
- DNA-Accreta (NCT02784886)
- Testing
- Women at high risk of MAP
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Angers
Amputation, Lower Extremity
Evaluation of Correlations Between Different Walk Tests in Patients With Transfemoral Amputees
Lower limb amputation (LLA) is a major public health problem, with significant human and financial impact. Epidemiological data remain scarce in the literature.
- Trial name
- NCT02766387
- Testing
- Evaluation of the correlation between walking speed in the 6MWT and in 2MWT, and the walking speed observed in the continuous 2km walk test and in the 10 meters walk test.
- Sponsor
- University Hospital, Angers
Small Cell Lung Cancer
SCLC on the 2nd Line With Relapsed After Response to Chemotherapy GFPC 01-2013
The purpose of this study was to determine prospectively in all patients with SCLC in second line therapy that progression-free survival with the expected reintroduction of platinum / etoposide is greater progression-free…
- Trial name
- CBPC (NCT02738346)
- Testing
- Carboplatin, Etoposide, Topotecan
- Where
- France
- Volunteers
- 164 people
- Sponsor
- University Hospital, Angers
Colonoscopy
Predictive Score of the Bowel Preparation Quality Based on a Self-administered Questionnaire
In France, nearly 1.3 million colonoscopies are performed each year. Colonoscopy is the gold standard in France for colorectal cancer screening in populations at risk. However, it has a number of limitations.
- Trial name
- PREPA-CO (NCT02712073)
- Testing
- Questionnaire
- Where
- 4 sites in France
- Volunteers
- 1,260 people
- Sponsor
- University Hospital, Angers
Liver Surgery
Enhanced Recovery After Hepatic Surgery (MultiPAS).
Enhanced rehabilitation programs are based on new therapies and treatment combinations to reduce the length of hospitalization, duration of postoperative convalescence, morbidity, but also the overall cost of care.
- Trial name
- MultiPAS (NCT02715427)
- Testing
- Conventional care, Enhanced recovery
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Healthy
CARDIOSPACE Evaluation in Healthy Volunteers
The aim of this porject is to test the Cardiospace system that integrates several medical devices to monitor the cardiovascular system: ECG Brachial blood pressure Continuous finger blood pressure Ultrasound Laser doppler +…
- Trial name
- CARDIOSPACE (NCT02704247)
- Testing
- CARDIOSPACE System
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Healthy, Sedentary
TEMIS: a Pilot Study to Evaluate a Device to Characterize Ambulatory Physical Activity
Physical inactivity is a major public health issue. Prescription of physical activity appears necessary in some situation with cardiovascular risk. It is important to both qualify and quantify daily physical activity.
- Trial name
- TEMIS (NCT02687659)
- Testing
- TEMIS system
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers