Clinical trials: sponsored by University Hospital, Angers
Social Cognition
Social Cognition in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis, also known as Charcot disease, is a neurodegenerative disease evidenced by gradual paralysis of the muscles involved in voluntary motor function.
- Trial name
- COSISLA (NCT04406675)
- Testing
- neuropsychological test
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Lateral Sclerosis Amyotrophy, Mindfulness Meditation
Psychological Management by Meditation of Full COnscience in Virtual REality of People With Amyotrophic Lateral Sclerosis: Effects on Cognition, Behavior, Quality of Life and Psychological Well-being
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results in progressive paralysis of the muscles involved in voluntary motor skills, speech, swallowing and breathing.
- Trial name
- COREVALS (NCT05409508)
- Testing
- mindfulness meditation care, no mindfulness meditation care
- Sponsor
- University Hospital, Angers
Leukemia, Lymphoma
Feasibility of an Adapted Sports Program Based on Fencing to Reduce Physical Deconditioning in Adult Hematology Patients
In 20 years, the prognosis of hematology patients has improved thanks to the development and adaptation of treatments and better risk management.
- Trial name
- EscrimHEMA (NCT06026046)
- Testing
- Adapted sport program based on fencing
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Intensive Care (ICU), Central Venous Catheter Related Infections
Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the ICU - A Randomized Controlled Trial
In the intensive care unit, patients' care and secure drugs administration require a central venous catheter. These invasive devices can lead to complications, particularly infections.
- Conditions
- Intensive Care (ICU), Central Venous Catheter Related Infections, Critical Care Nursing, Catheter-associated Bloodstream Infections (CLABSI)
- Trial name
- TANDOORI (NCT07183592)
- Testing
- 7-day Infusion set replacement, 4-day infusion set replacement
- Where
- 27 sites in France
- Volunteers
- 2,830 people
- Sponsor
- University Hospital, Angers
Acute Disseminated Encephalomyelitis, Encephalitis Autoimmune
High-throughput Omic Technology for Identification of Biomarkers of Relapsing Acute Disseminated Encephalomyelitis in Immune Cell Network
Acute disseminated encephalomyelitis (ADEM) is a neuroinflammatory disorder of the central nervous system, manifesting itself as impaired consciousness, even to the point of coma, and multifocal neurological deficits.
- Trial name
- HOT-BRAIN (NCT06863974)
- Testing
- Blood test
- Where
- 8 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
ARDS, Human
Feasabilty and Physiological Effects of a Ventilation Strategy Combining PEEP and Tidal Volume Titration According to Inspiratory and Expiratory Transpulmonary Pressures in ARDS Patients.
Expiratory or inspiratory transpulmonary pressures have been proposed to optimize ventilator settings in patients with ARDS. The aim of this study is to assess the feasibility and the physiological effects of a new method based…
- Trial name
- PULMOESO (NCT05337059)
- Testing
- PEEP and Tidal Volume Titration
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Angers
Suicidal Behavior, Adolescent
Suicidal Behavior in Adolescents and Executive Functions
Suicide is a major public health concern, particularly among young people. In France, around 400 adolescents die by suicide every year, and suicide attempts are most frequent during adolescence.
- Trial name
- SAFE (NCT07422493)
- Testing
- Neuropsychological Tests and Psychiatric Tests
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Chronic Insomnia
Facial Emotion Recognition in Insomnia and Emotional Regulation
Introduction Chronic insomnia is a prevalent disorder in the general population, affecting up to 20% according to French National Institute of Health and Medical Research, leading to a decline in quality of life and an increased…
- Trial name
- REFIRE (NCT06251258)
- Testing
- Facial emotion recognition test with and without eye-tracking and Cognitive Emotion Regulation. Questionnaire (CERQ)
- Where
- France
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Myocarditis Acute, Ventricular Arrythmia
Ventricular Arrhythmia After Myocarditis in Sportsman
The study aims to assess the prevalence of ventricular rhythmic disorder after an acute myocarditis in sportsmen. 50 patients with acute myocarditis, confirmed by MRI, will be assessed by ECG Holter and Treadmill stress test…
- Trial name
- ARYMYS (NCT03842592)
- Testing
- Treadmill Stress test
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Hyperbaric Oxygen, Genotoxicity
Assessment of the Impact of Increased Production of Reactive Oxygen Species Produced During Repeated Sessions of Hyperbaric Oxygen Therapy in Patients Undergoing Radiotherapy for Neoplasia, on the Occurrence of DNA Damage
Hyperbaric Oxygen Therapy (HBOT) is a treatment involving the administration of oxygen at pressures higher than atmospheric pressure, with numerous potential indications such as radiation-induced tissue damage, chronic wounds…
- Conditions
- Hyperbaric Oxygen, Genotoxicity, Malignancy
- Trial name
- OXYBAR (NCT06999785)
- Testing
- Blood test
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Pseudoxanthoma Elasticum
Impact of Optimized Recruitment and Follow-up of Patients With Pseudoxanthoma Elasticum (PXE)
Pseudoxanthoma elasticum (PXE) is a rare genetic disorder characterized by ectopic calcifications in the skin, retina and arterial walls. Angers University Hospital is the national rare disease reference center (CRMR) for PXE.
- Trial name
- REMOTE-PXE (NCT06636344)
- Testing
- Pseudoxanthoma Elasticum
- Where
- France
- Volunteers
- 650 people
- Sponsor
- University Hospital, Angers
Wound Heal, Critical Illness
Medical Honey for Wound Treatment in Intensive Care. (MICARéa) Randomized, Controlled, Single-center Pilot Study.
Wound management is a real public health issue in France. To date, a wide range of devices exists to treat these wounds, depending on their nature and stage of evolution.
- Trial name
- MICAREA (NCT06150326)
- Testing
- medical honey Activon® 25g Tube, standard of care
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Mild Cognitive Impairment
EVASION: Effect of VisuAl Stimulation on attentION
The main objective is to compare changes in information processing speed after 30 days of intervention in participants with a dysexecutive mild cognitive impairment (MCI) and receiving either cognitive stimulation by adapted…
- Trial name
- EVASION (NCT05791994)
- Testing
- Visual cognitive stimulation exercises, Broadcast of a television program
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Shock
Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure
The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.
- Trial name
- MAPAKI (NCT05655065)
- Testing
- increase of mean arterial pressure at 65-70 mmHg, increase of mean arterial pressure at 80-85 mmHg
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Sleep Apnea, Obstructive, Endothelial Dysfunction
Impact of the Mandibular Advancement Device on Sleep Apnea During CPAP Withdrawal
Obstructive sleep apnea hypopnea syndrome (OSAS) is a frequent disease with neuropsychological and cardiovascular (CV) consequences.
- Trial name
- ORTAP (NCT05939934)
- Testing
- Mandibular advancement device treatment
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Endocrine; Deficiency, Hypothalamo-Pituitary Disorder
Brain Irradiation for Childhood Cancer - Endocrine Monitoring During the First Years
BICHE- 1: Brain Irradiation for Childhood cancer - Endocrine monitoring during the first five years is a study of endocrine monitoring after cerebral radiotherapy.
- Conditions
- Endocrine; Deficiency, Hypothalamo-Pituitary Disorder, Radiotherapy Side Effect
- Trial name
- BIChE-1 (NCT06618703)
- Testing
- Blood sample, urine sample, osteodensitometry
- Where
- 3 sites in France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Angers
Spastic Foot
Spasticity Multidisciplinary Management : QoL and Physical Activity Measurement With Connected Health Devices (PEPS)
PEPS is a 18 months prospective bicentric study on 30 patients with spastic foot. The main objective is to evaluate the mean daily gait perimeter modifications mesured by connected watch, 6 months after spastic equinus foot…
- Trial name
- PEPS (NCT06138418)
- Testing
- Neurotomy
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Angers
Huntington Disease, Autobiographical Memory
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by progressively worsening motor, cognitive, psychiatric, and behavioral deficits.
- Trial name
- MAMOC-MH (NCT07409597)
- Testing
- neuropsychological tests, Eye tracker use
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Thoracic Outlet Syndrome
DEFILE-QoL5 - Evaluation of the Long-term Surgical Management of the Thoraco-brachial Displacement Syndrome
The study concerns patients hospitalized in vascular and thoracic surgery in 2016 at the University Hospital of Angers for the management of a thoraco-brachial outlet syndrome.
- Trial name
- DEFILE-QoL5 (NCT06036888)
- Testing
- questionaries completion
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Angers
Nicotinamide Adverse Reaction
Tolerance and Efficacy Nicotinamide (Vitamin B3) in Dominant Optic Atrophy OPA1
Dominant Optic Atrophy (hereafter known as DOA) is a neurodegenerative pathology of the optic nerve inducing progressive loss of central visual field and visual acuity. There is currently no proven treatment for this disease.
- Trial name
- NICOPA1-TOL (NCT06007391)
- Testing
- Nicotinamide
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Angers