Clinical trials: sponsored by University Hospital, Antwerp
Ventilator-induced Diaphragm Dysfunction, VIDD
An InnovaTive Approach to Ventilator-Induced Diaphragmatic Dysfunction
'Ventilator-Induced Diaphragmatic Dysfunction (VIDD) was originally described by Vassilakopoulos and Petrof in 1998, where it is used to cover the effects of mechanical ventilation and respiratory muscle unloading on the…
- Trial name
- ITAVIDD (NCT02299986)
- Testing
- Ultrasound measurement
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University Hospital, Antwerp
Parkinson's Disease
Mindfulness Based Intervention (MBI) on the Quality of Life and Non-Motor Symptoms (NMS) of Persons With PD
Scientific Abstract: The investigators propose a study to examine the impact of a Mindfulness Based Intervention (MBI) on the quality of life and Non-Motor Symptoms (NMS) of persons with Parkinson's disease (PD).
- Trial name
- NCT01607697
- Testing
- Mindfulness Training
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Antwerp
Healthy Participants
The Influence of Posture on Airway Diameter, Resistance and Airflow Distribution in Healthy Subjects
FRI could give the opportunity to investigate the possible effect of a lateral posture on airway diameter and airflow distributions.
- Trial name
- NCT01893697
- Testing
- HRCT scan in a specific postural position
- Where
- Belgium
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Asthma
Study to Assess the Effect of the NEXThaler® Device (DPI - Dry Powder Inhaler) on the Central and Peripheral Airway Dimensions in Asthmatic Patients
The objective of this study is to evaluate the effect of the combination of formoterol and beclometasone dipropionate in a dry powder inhaler (NEXThaler®) on central and peripheral airway dimensions in asthmatic patients.
- Trial name
- NCT01650441
- Testing
- Beclomethasone dipropionate 100 µg + formoterol fumarate 6 µg, CT thorax
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea Syndrome
Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients
In this open prospective study 40 patients who received Mandibular Replacement Appliance (MRA) Therapy as treatment of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) will be included.
- Trial name
- NCT01524510
- Testing
- CT scan, Alice PDx polygraphy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Respiratory Patients
Clinical Validation of New Breathing Sensors in Patients With Respiratory Insufficiency
The NXT_SLEEP study, bringing together industry partners, research groups and (home) care providers, tackles will develop a next generation sleep-monitoring platform that consists of less obtrusive sensors, and that delivers…
- Trial name
- NXT_SLEEP (NCT01904344)
- Testing
- Sensor testing and validation
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- University Hospital, Antwerp
Chronic Obstructive Pulmonary Disease
Effects of IPV Assessed With Functional Imaging
In this study the invetigators seek an answer on the following hypothesis: What are the long term effects of an IPV treatment evaluated with classical outcome parameters? (FEV1, Raw) Is the possible effect noticeable on the novel…
- Trial name
- IPV (NCT01671540)
- Testing
- intrapulmonary percussive ventilation, standard treatment
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Anesthetics, Local, Nerve Block
Thermal QST for Interscale Block Evaluation
Thermal quantitative sensory testing (QST) is a method to evaluate peripheral nerve blocks in a quantitative way. It assesses the neurosensory effects of local anesthetics, like nerve block intensity, duration, recovery…
- Trial name
- NCT02271867
- Testing
- Interscalene block
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- University Hospital, Antwerp
-Postoperative Pain
Ultrasound Guided Lateral Femoral Cutaneous Block (LFCNB) And Femoral Nerve Block (FNB) For Postoperative Pain Control After Hip Surgery
Evaluation of the combination of lateral femoral cutaneous nerve "single shot" and femoral nerve "single shot" block as effective and safe alternative postoperative analgesic technique after hip replacement surgery.
- Trial name
- NCT02056145
- Testing
- LFCNB, FNB
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- University Hospital, Antwerp
Pulmonary Disease, Healthy
Reliability of Different FOT Devices to Measure the Human Respiratory Impedance
The objective of the study is to evaluate the reliability of the impedance data in adult subjects measured with five different FOT devices.
- Trial name
- NCT01868607
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Noise-induced Tinnitus, Noise-induced Hearing Loss
Prevention of Noise-induced Damage by Use of Antioxidants
The current study is a dubble-blinde placebo-controlled cross-over study verifying the preventive effect of antioxidants on noise-induced hearing loss (NIHL) and noise-induced tinnitus (NIT).
- Trial name
- NCT01727492
- Testing
- Antioxidantia
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Non-Small-Cell-Lung Cancer
Evaluation of Carboplatin Plus Gemcitabine Followed by Concomitant Chemoradiation for Non-resectable Stage III NSCLC
The aim of this study is to evaluate whether by combining a carboplatin-gemcitabine based induction chemotherapy with weekly cisplatin during standard thoracic radiotherapy it is possible to obtain optimal efficacy with minimal…
- Trial name
- CHER@NOS (NCT00463515)
- Testing
- carboplatin/gemcitabine, cisplatin/radiation therapy
- Where
- 3 sites in Belgium
- Volunteers
- 77 people
- Sponsor
- University Hospital, Antwerp
Non-Small Cell Lung Cancer
Enoxaparin Low Molecular Weight Heparin (LMWH) in Advanced Non Small Cell Lung Cancer: Effect on Survival and Symptom Control in Patients Undergoing First Line Chemotherapy (SYRINGES)
Rationale: a number of recent phase III randomized trials have shown a survival benefit of a treatment with subcutaneous low-molecular weight heparin in patients with advanced solid malignancies.
- Trial name
- SYRINGES (NCT00771563)
- Testing
- cisplatin + docetaxel, cisplatin + docetaxel + enoxaparin
- Where
- 2 sites in Belgium
- Volunteers
- 104 people
- Sponsor
- University Hospital, Antwerp
COPD
Prospective Exploratory Study to Assess the Effects of the AlphaCore® Device in Patients With COPD
Title: Open-label, prospective exploratory study to assess the effects of the AlphaCore® device on central and peripheral airway dimensions in patients with COPD.
- Trial name
- NCT01720680
- Testing
- Low dose multislice CT thorax, AlphaCore® device
- Where
- Belgium
- Volunteers
- 2 people
- Sponsor
- University Hospital, Antwerp
Tinnitus
Effect of Time Shift of Transcranial Direct Current Stimulation (tDCS) for Treatment of Acute Tinnitus
The treatment for patients with acute tinnitus consists of Methylprednisolone and hyperbaric oxygen therapy. For this study transcranial direct current stimulation (tDCS) was added to the protocol.
- Trial name
- NCT01886729
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Sleep-disordered Breathing
The 1 Year Follow-up Objective Oral Appliance Compliance
The investigators will perform a 1-year clinical trial measuring objective compliance during mandibular advancement device (MAD) treatment.
- Trial name
- NCT01533623
- Testing
- Mandibular Advancement Device
- Where
- Belgium
- Volunteers
- 51 people
- Sponsor
- University Hospital, Antwerp
Critical Illness
Glucose Control in the ICU Using Continuous Glucose Monitoring
Stress hyperglycemia occurs in 50-85% of patients admitted to a medical intensive care unit (MICU) and is associated with increased morbidity and mortality.
- Trial name
- REGIMEN (NCT01799512)
- Testing
- experimental: real-time continuous glucose monitoring, Active comparator: blinded continuous glucose monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 35 people
- Sponsor
- University Hospital, Antwerp
Obesity
Environmental Chemicals and Their Role in Obesity
Hormonal disruption is the inappropriate alteration of the hormonal system by chemical substances that are present in our environment.
- Trial name
- ENDORUP (NCT01778868)
- Where
- Belgium
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Chronic Obstructive Pulmonary Disease
Study to Assess the Effect of Formoterol and Beclomethasone Dipropionate in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this study is to evaluate the effect of the combination of formoterol and beclometasone dipropionate on central and peripheral airway dimensions in COPD patients using Computational Fluid Dynamics (CFD).
- Trial name
- NCT01204034
- Testing
- Inuvair
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- University Hospital, Antwerp
COPD
Pilot Study to Assess the Effect of High Dose N-acetylcysteine (NAC) in Chronic Obstructive Pulmonary Disease (COPD) Patients
Studies suggest that N-acetylcysteine (NAC) potentially reduces inflammation and hyperinflation in patients with COPD. In this pilot study the efficacy, safety and tolerability of high dose NAC in 12 patients with moderate COPD…
- Trial name
- NCT00969904
- Testing
- N-acetylcysteine
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- University Hospital, Antwerp