Clinical trials: sponsored by University Hospital, Antwerp
Respiratory Muscles, Respiration, Artificial
Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation
This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm.
- Conditions
- Respiratory Muscles, Respiration, Artificial, Respiratory Function Tests
- Trial name
- VIREM (NCT05459116)
- Testing
- Placement of nasogastric balloon
- Where
- 3 sites in Belgium, Canada
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Ventilator Weaning, Respiration, Artificial
Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training
The TONES trial aims to evaluate the neuroventilatory efficiency (NVE = tidal volume / peak voltage of diaphragm contraction) measured during a zero-assist manoeuvre (ZAM, i.e. with PEEP but without pressure support).
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Muscles, Respiratory Failure
- Trial name
- TONES (NCT05380687)
- Testing
- Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Antwerp
Liver Failure, AKI - Acute Kidney Injury
Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications
Study design A retrospective cohort study will be conducted to compare the efficacy and safety of citrate anticoagulation in CRRT among patients with liver failure/dysfunction and severe shock. Objectives 1.
- Trial name
- Caution (NCT06908746)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Bloodstream Infection
The Clinical Impact of Cobas® Eplex Blood Culture Panels for the Diagnosis of Bacteremia and Fungemia
A quality improvement study on the diagnostics and clinical management of bloodstream infection episodes. Patients of all ages and genders with positive blood cultures collected for standard patient care are included in the…
- Trial name
- NCT06576258
- Testing
- cobas eplex multiplex PCR
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Myelodysplastic Syndromes
Observational Study Towards the Impact of Newly Started Treatment in MDS on QoL
Study type An observational study conducted in different hematological centers in Belgium. Study objectives Primary objective: To assess the impact of newly started treatments on the QOL of patients suffering from myelodysplastic…
- Trial name
- Be-QUALMS (NCT04053933)
- Where
- 21 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Antwerp
Malignant Liver Tumor, Benign Liver Tumor
Hepatic Excision and Ablation Log
This study aims to establish a registry for liver surgery and ablation procedures to improve patient care, advance research, and enhance surgical quality.
- Trial name
- HEAL (NCT06870461)
- Testing
- Liver surgery / ablation
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Antwerp
Reconstructive Flap Surgery, Fasciocutaneous Anterolateral Thigh Flap
Anterolateral Tigh (ALT) Flaps Oxygenation Monitoring by NIRS
The goal of this observational study is to conduct postoperative monitoring in patients who have undergone upper or lower limb reconstructive surgery with an anterolateral thigh flap, by employing the gold standard approach…
- Conditions
- Reconstructive Flap Surgery, Fasciocutaneous Anterolateral Thigh Flap, Postoperative Monitoring, Flap Ischemia
- Trial name
- NCT06744387
- Testing
- clinical assessments and tissue oxygenation monitoring by Near Infrared Spectroscopy
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Fluid and Electrolyte Imbalance, Body Weight Changes
Bio Impedance Monitoring as a Tool to Assess Fluid Status in the Pediatric Surgical Patient? (PedFluid Study)
The baseline infusion rate during surgery for pediatric patients still is the 'Holliday and Segar' rule (also known as the 4/2/1 rule) The question arises if this rule is not outdated, since it was calculated based on the caloric…
- Conditions
- Fluid and Electrolyte Imbalance, Body Weight Changes, Children, Only
- Trial name
- NCT05220709
- Testing
- bio impedance spectroscopy by means of the Body Composition Monitor (Name of the device is BCM from Fresenius Medical Care D GmbH)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Chronic Pain Syndromes, CRPS
Neuro-Pain Provides a Dynamic and Interactive Register for the Invasvive Neuromodulatory Therapies for Different Chronic Pain Syndromes. Patients Living in Belgium and Suffering From Persistent Spinal Pain Syndromes Type 2 as Well as Suffering From Complex Regional Pain Syndromes Are Included.
Patients suffereing from chronic pain due to persistent spinal pain syndromes or complex regional pain syndromes and living in Belgium will be included in this register once they are being considered for a treatment with invasive…
- Trial name
- NCT06835868
- Testing
- Spinal cord stimulation
- Where
- Belgium
- Volunteers
- 7,000 people
- Sponsor
- University Hospital, Antwerp
Cochlear Impant Children
Implementation of the International Classification of Functioning, Disability and Health Model in Paediatric Cochlear Implant Recipients
The aim of this study is to implement the International Classification of Functioning, disability and health (ICF) in paediatric Cochlear Implant (CI) recipients (<18 years) with prelingual sensorineural hearing loss in a…
- Trial name
- NCT06841900
- Testing
- Cochlear Implantation
- Where
- 6 sites in Australia, Belgium and 4 more
- Volunteers
- 120 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea (OSA), Mandibular Advancement Device
Clinial Study of Treatment With Mandibular Advancement Device in Patients With Obstructive Sleep Apnea Across 6 General Hospitals
Study Objectives: To retrospectively study mandibular advancement treatment efficacy using apnea-hypopnea index (AHI) and oxygen desaturation index (ODI), in a large cohort of patients, in 'real world' settings across 6 general…
- Trial name
- RACEMADT (NCT06837285)
- Testing
- mandibular advancement device
- Where
- 6 sites in Belgium
- Volunteers
- 182 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
First Line Obstructive Sleep Apnea Treatment Study
The main objective is to evaluate the overall effectiveness of MAD therapy as a first line treatment, including both efficacy in terms of reduction in OSA severity as well as objective compliance, in patients recently diagnosed…
- Trial name
- FLOSAT (NCT05393531)
- Testing
- Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP)
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Pathophysiological Endotyping Using Baseline Polysomnography Data
The study is designed to develop models to predict site of collapse information using routine polysomnography. In an observational study, the investigators will study 1000 patients with obstructive sleep apnea (OSA) who have had…
- Trial name
- NCT05267808
- Testing
- Drug-induced sleep endoscopy
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Antwerp
Cardiac Pacing, Artificial, Aneurysm, Brain
Rapid Ventricular Pacing During Cerebral Aneurysm Surgery: a Study Concerning the Safety for Heart and Brain
Rapid ventricular pacing (RVP) is a technique to obtain flow arrest for short periods of time during dissection or rupture of the aneurysm. RVP results in an adequate fall in blood pressure which presents as an on-off phenomenon.
- Conditions
- Cardiac Pacing, Artificial, Aneurysm, Brain, Arteriovenous Malformations, Cerebral
- Trial name
- NCT03184233
- Testing
- Rapid ventricular pacing, No rapid ventricular pacing
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- University Hospital, Antwerp
Laryngoscopy, Child
Correlation Between Sedation Depth Monitoring and Reflexes During Intravenous Anesthesia With Dexmedetomidine and Remifentanil in Children Undergoing Direct Laryngoscopy for Surgical Procedures
This study evaluates the correlation between sedation depth monitoring obtained by NeuroSENSE ® NS 701 Monitor and reflexes during intravenous anesthesia in children undergoing direct laryngoscopy for surgical procedures.
- Conditions
- Laryngoscopy, Child, Monitoring
- Trial name
- NCT03426579
- Testing
- NeuroSENSE ®in children
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Mechanical Ventilation, Artificial Respiration
Dead Space in Mechanical Ventilation With Constant Expiratory Flow
Conventional continuous mandatory mechanical ventilation relies on the passive recoil of the chest wall for expiration. This results in an exponentially decreasing expiratory flow.
- Trial name
- DeXFLoW (NCT06024993)
- Testing
- Flow-controlled ventilation (FCV), Conventional volume-controlled ventilation (VCV)
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Antwerp
Limbal Stem Cell Deficiency
Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial
This project aims to conduct a multicentre human clinical trial to effectively diagnose and treat limbal stem cell deficiency (LSCD) which can be caused by a number of different disease processes, all of which have a common…
- Trial name
- MLEC (NCT02318485)
- Testing
- Limbal epithelial stem cell graft
- Where
- 3 sites in Belgium
- Volunteers
- 27 people
- Sponsor
- University Hospital, Antwerp
Heart Arrest, Brain Injuries
A Comprehensive Evaluation of Hyperbaric Oxygen Therapy in Resuscitation Medicine - a Pilot Study (HOT-RESUS 1 Trial)
In this prospective pilot study, the effects of hyperbaric oxygen therapy (HBOT) in post-cardiac arrest syndrome will be evaluated. However, the primary outcome of this pilot study will be the feasibility of this approach.
- Trial name
- HOT-RESUS 1 (NCT05646875)
- Testing
- hyperbaric oxygen therapy
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Hearing Loss, Sensorineural, Severe, Hearing Loss, Sensorineural, Bilateral
Hear Again, Work Again
Project synopsis: This prospective cohort study investigates impact of (1) hearing loss and (2) cochlear implantation on cost and health state on one hand, and employment, productivity and social wellbeing on the other hand in a…
- Conditions
- Hearing Loss, Sensorineural, Severe, Hearing Loss, Sensorineural, Bilateral, Hearing Loss, Unilateral, Hearing Loss, Sensorineural, Profound
- Trial name
- NCT05196022
- Testing
- Cochlear implant
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Glioblastoma, Renal Cell Carcinoma
Dendritic Cell Vaccination for Patients with Solid Tumors
The aim of this study is to evaluate the immunogenicity and clinical efficacy of intradermal vaccination with autologous RNA-modified dendritic cells (DCs) - engineered to express the WT1 protein - in patients with limited spread…
- Conditions
- Glioblastoma, Renal Cell Carcinoma, Sarcomas, Breast Cancers
- Trial name
- NCT01291420
- Testing
- autologous dendritic cell vaccination
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University Hospital, Antwerp